SEM4F_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEM4F_HUMAN
• UniProt AC: O95754
• Protein Name: Semaphorin-4F
• Gene Name: SEMA4F
• Organism: Homo sapiens (Human).
• Sequence Length: 770
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Has growth cone collapse activity against retinal ganglion-cell axons..
• Protein Sequence: MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQPSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	N-linked_Glycosylation	FAVPHTYNYSVLLVD HCCCCCEEEEEEEEC	24.61	UniProtKB CARBOHYD
78	Phosphorylation	DPASHTLYVGARDTI CCCCCEEEECCCCEE	9.67	-
133	N-linked_Glycosylation	VQILAIANASHLLTC HHHHHHHCHHHHHCC	35.54	UniProtKB CARBOHYD
169	Ubiquitination	RLESGRGKCPFEPAQ HHHCCCCCCCCCHHH	37.06	-
178	Phosphorylation	PFEPAQRSAAVMAGG CCCHHHHHHHHHHCC	14.43	-
188	Phosphorylation	VMAGGVLYAATVKNY HHHCCEEEEEEEHHH	7.56	-
191	Phosphorylation	GGVLYAATVKNYLGT CCEEEEEEEHHHHCC	24.68	-
289	Phosphorylation	TLQQRWTTFLKADLL HHHHHHHHHHHHHEE	21.73	-
390	Ubiquitination	ECITNNMKLRHFGSS CCCCCCCEEECCCCC	44.48	-
399	Phosphorylation	RHFGSSLSLPDRVLT ECCCCCCCCCHHHHH	39.54	24719451
450	Phosphorylation	TSLSGKEYDVLYLGT HHCCCCCEEEEEEEC	18.16	-
454	Phosphorylation	GKEYDVLYLGTEDGH CCCEEEEEEECCCCC	11.70	-
509	N-linked_Glycosylation	RTEVTQVNTTNCGRL CEEEEEEECCCCCCC	31.22	UniProtKB CARBOHYD
718	Phosphorylation	SYSQDPPSPSPEDER CCCCCCCCCCCCCCC	43.32	28348404
720	Phosphorylation	SQDPPSPSPEDERLP CCCCCCCCCCCCCCC	45.30	27050516
735	Phosphorylation	LALAKRGSGFGGFSP HHHHHCCCCCCCCCC	34.67	24719451
741	Phosphorylation	GSGFGGFSPPFLLDP CCCCCCCCCCCCCCC	34.63	21712546
751	Phosphorylation	FLLDPCPSPAHIRLT CCCCCCCCCCEEEEC	41.24	21712546
768	Phosphorylation	PLATCDETSI----- CCCCCCCCCC-----	20.62	23312004
769	Phosphorylation	LATCDETSI------ CCCCCCCCC------	25.01	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEM4F_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEM4F_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEM4F_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
USO1_HUMAN	USO1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.