FUT11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FUT11_HUMAN
• UniProt AC: Q495W5
• Protein Name: Alpha-(1,3)-fucosyltransferase 11
• Gene Name: FUT11
• Organism: Homo sapiens (Human).
• Sequence Length: 492
• Subcellular Localization: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
• Protein Description: Probable fucosyltransferase..
• Protein Sequence: MAAGPIRVVLVLLGVLSVCAASGHGSVAEREAGGEAEWAEPWDGAVFRPPSALGAVGVTRSSGTPRPGREEAGDLPVLLWWSPGLFPHFPGDSERIECARGACVASRNRRALRDSRTRALLFYGTDFRASAAPLPRLAHQSWALLHEESPLNNFLLSHGPGIRLFNLTSTFSRHSDYPLSLQWLPGTAYLRRPVPPPMERAEWRRRGYAPLLYLQSHCDVPADRDRYVRELMRHIPVDSYGKCLQNRELPTARLQDTATATTEDPELLAFLSRYKFHLALENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLAEFIDFLDKNDEEYMKYLAYKQPGGITNQFLLDSLKHREWGVNDPLLPNYLNGFECFVCDYELARLDAEKAHAASPGDSPVFEPHIAQPSHMDCPVPTPGFGNVEEIPENDSWKEMWLQDYWQGLDQGEALTAMIHNNETEQTKFWDYLHEIFMKRQHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	LVLLGVLSVCAASGH HHHHHHHHHHHHHCC	16.85	-
26	Phosphorylation	CAASGHGSVAEREAG HHHHCCCCHHHHHCC	16.69	-
59	O-linked_Glycosylation	ALGAVGVTRSSGTPR HHCCCCEECCCCCCC	20.93	55834533
61	Phosphorylation	GAVGVTRSSGTPRPG CCCCEECCCCCCCCC	24.61	22210691
64	O-linked_Glycosylation	GVTRSSGTPRPGREE CEECCCCCCCCCCHH	20.33	55834537
130	Phosphorylation	YGTDFRASAAPLPRL HCCCCCCCCCCCHHH	22.25	22985185
166	N-linked_Glycosylation	GPGIRLFNLTSTFSR CCCEEEEECEECCCC	47.18	UniProtKB CARBOHYD
208	Phosphorylation	AEWRRRGYAPLLYLQ HHHHHCCCCCHHHHH	11.84	29759185
213	Phosphorylation	RGYAPLLYLQSHCDV CCCCCHHHHHHCCCC	15.46	29759185
216	Phosphorylation	APLLYLQSHCDVPAD CCHHHHHHCCCCCCC	24.40	29759185
242	Ubiquitination	IPVDSYGKCLQNREL CCCCCCHHHHCCCCC	24.44	21963094
349	Ubiquitination	KNDEEYMKYLAYKQP CCCHHHHHHHHHCCC	35.89	29967540
350	Phosphorylation	NDEEYMKYLAYKQPG CCHHHHHHHHHCCCC	4.69	-
353	Phosphorylation	EYMKYLAYKQPGGIT HHHHHHHHCCCCCCC	13.94	-
354	Ubiquitination	YMKYLAYKQPGGITN HHHHHHHCCCCCCCC	44.39	29967540
443	N-linked_Glycosylation	NVEEIPENDSWKEMW CCCCCCCCCCHHHHH	43.17	19159218

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FUT11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FUT11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FUT11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FUT11_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-443, AND MASSSPECTROMETRY.
PubMed: 19159218