NOMO3_HUMAN - dbPTM
NOMO3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOMO3_HUMAN
UniProt AC P69849
Protein Name Nodal modulator 3
Gene Name NOMO3
Organism Homo sapiens (Human).
Sequence Length 1222
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description May antagonize Nodal signaling..
Protein Sequence MLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGFSVCGQISIIRFPDTVKQMNKYKVVLSSQDKDKSLVTVETDAHGSFCFKANPGTYKVQVMVPEAETRAGLTLKPQTFPLTVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKVNAMTFTFDNVLPGKYKISIMHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGRENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQEREKNGNEEGEERMTKPPVQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSMEAVVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVTSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGLFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSENLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKHITLIFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVGALGQAASDNSGPEDAKRQAKKQKTRRT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50N-linked_GlycosylationVKSDVEINYSLIEIK
CCCCCEECEEEEEEE		13.56UniProtKB CARBOHYD
61AcetylationIEIKLYTKHGTLKYQ
EEEEEEECCCEEEEE		26.8727452117
61UbiquitinationIEIKLYTKHGTLKYQ
EEEEEEECCCEEEEE		26.87-
66UbiquitinationYTKHGTLKYQTDCAP
EECCCEEEEEEECCC		34.84-
85UbiquitinationFMIPLYDKGDFILKI
EEEEEEECCCEEEEE		46.99-
134UbiquitinationTGFSVNGKVLSKGQP
EEEEECCEEECCCCC		34.5021890473
138UbiquitinationVNGKVLSKGQPLGPA
ECCEEECCCCCCCCC		58.3621890473
150PhosphorylationGPAGVQVSLRNTGTE
CCCCEEEEEECCCCC		12.4320068231
154PhosphorylationVQVSLRNTGTEAKIQ
EEEEEECCCCCEEEE		38.7622210691
156PhosphorylationVSLRNTGTEAKIQST
EEEECCCCCEEEEEE		30.6322210691
159SumoylationRNTGTEAKIQSTVTQ
ECCCCCEEEEEEEEC		34.74-
159UbiquitinationRNTGTEAKIQSTVTQ
ECCCCCEEEEEEEEC		34.7421906983
159SumoylationRNTGTEAKIQSTVTQ
ECCCCCEEEEEEEEC		34.74-
170UbiquitinationTVTQPGGKFAFFKVL
EEECCCCEEEEEEEC		39.1621890473
170AcetylationTVTQPGGKFAFFKVL
EEECCCCEEEEEEEC		39.1671393
175UbiquitinationGGKFAFFKVLPGDYE
CCEEEEEEECCCCEE		36.09-
181PhosphorylationFKVLPGDYEILATHP
EEECCCCEEEEECCC		15.70-
193UbiquitinationTHPTWALKEASTTVR
CCCCEECCCCCCEEE		43.4121890473
218N-linked_GlycosylationPLIVAGYNVSGSVRS
CEEEEEEEECCEECC		22.14UniProtKB CARBOHYD
231UbiquitinationRSDGEPMKGVKFLLF
CCCCCCCCCCEEEEE		71.86-
239PhosphorylationGVKFLLFSSLVTKED
CCEEEEEECCCCHHH		23.8021406692
240PhosphorylationVKFLLFSSLVTKEDV
CEEEEEECCCCHHHH		21.3721406692
243PhosphorylationLLFSSLVTKEDVLGC
EEEECCCCHHHHCCC		33.7321406692
356UbiquitinationVTLNNQIKVKTKADG
EEECCEEEEEECCCC		28.1021906983
358UbiquitinationLNNQIKVKTKADGSF
ECCEEEEEECCCCCE		39.03-
360UbiquitinationNQIKVKTKADGSFRL
CEEEEEECCCCCEEE		38.47-
369N-linked_GlycosylationDGSFRLENITTGTYT
CCCEEEEEECCEEEE		41.3120068230
369N-linked_GlycosylationDGSFRLENITTGTYT
CCCEEEEEECCEEEE		41.31-
385PhosphorylationHAQKEHLYFETVTIK
EEECCCEEEEEEEEE		10.9820068231
422PhosphorylationSIIRFPDTVKQMNKY
EEEECCHHHHHHCCE		29.82-
424UbiquitinationIRFPDTVKQMNKYKV
EECCHHHHHHCCEEE		46.02-
430UbiquitinationVKQMNKYKVVLSSQD
HHHHCCEEEEEECCC		27.72-
438UbiquitinationVVLSSQDKDKSLVTV
EEEECCCCCCCCEEE		60.46-
438AcetylationVVLSSQDKDKSLVTV
EEEECCCCCCCCEEE		60.4626051181
440UbiquitinationLSSQDKDKSLVTVET
EECCCCCCCCEEEEE		51.97-
463UbiquitinationKANPGTYKVQVMVPE
ECCCCEEEEEEEECC		26.48-
467SulfoxidationGTYKVQVMVPEAETR
CEEEEEEEECCCCCC		2.0221406390
478PhosphorylationAETRAGLTLKPQTFP
CCCCCCCEECCCEEC		31.6420068231
483PhosphorylationGLTLKPQTFPLTVTD
CCEECCCEECCCCCC		35.4320068231
487PhosphorylationKPQTFPLTVTDRPVM
CCCEECCCCCCCCCC		22.9220068231
489PhosphorylationQTFPLTVTDRPVMDV
CEECCCCCCCCCCHH		22.5120068231
504PhosphorylationAFVQFLASVSGKVSC
HHHHHHHHCCCCEEE		20.9727732954
506PhosphorylationVQFLASVSGKVSCLD
HHHHHHCCCCEEECC		30.3327732954
539AcetylationRSLQLSGKVNAMTFT
CCEEEECCEEEEEEE		29.0112431355
554UbiquitinationFDNVLPGKYKISIMH
ECCCCCCCEEEEEEE		41.2421906983
556UbiquitinationNVLPGKYKISIMHED
CCCCCCEEEEEEECC		33.20-
618N-linked_GlycosylationRENVGIYNLSKGVNR
CEEEEEEECCCCCCC		35.60UniProtKB CARBOHYD
618N-linked_GlycosylationRENVGIYNLSKGVNR
CEEEEEEECCCCCCC		35.6020068230
630UbiquitinationVNRFCLSKPGVYKVT
CCCCCCCCCCEEEEC		32.6121890473
630AcetylationVNRFCLSKPGVYKVT
CCCCCCCCCCEEEEC		32.6125825284
635UbiquitinationLSKPGVYKVTPRSCH
CCCCCEEEECCCCCC		36.91-
635AcetylationLSKPGVYKVTPRSCH
CCCCCEEEECCCCCC		36.9125038526
649PhosphorylationHRFEQAFYTYDTSSP
CCCEEEEEECCCCCC		13.86-
650PhosphorylationRFEQAFYTYDTSSPS
CCEEEEEECCCCCCC		14.41-
653PhosphorylationQAFYTYDTSSPSILT
EEEEECCCCCCCCHH		22.23-
660PhosphorylationTSSPSILTLTAIRHH
CCCCCCHHHHHHHCH		22.01-
700UbiquitinationALVLGPLKSVQELRR
EEEEEECHHHHHHHH		52.2821890473
762UbiquitinationYWARSGEKITVTPSS
EEECCCCEEEECCCC		47.4021890473
770UbiquitinationITVTPSSKELLFYPP
EEECCCCCEEEECCC		57.63-
788GlutathionylationAVVSGESCPGKLIEI
EEECCCCCCCEEEEE		4.4822555962
791UbiquitinationSGESCPGKLIEIHGK
CCCCCCCEEEEEECC		31.28-
825PhosphorylationISEKGASSPLITVFT
EECCCCCCCEEEEEE		24.16-
835UbiquitinationITVFTDDKGAYSVGP
EEEEECCCCCEEECC		48.53-
845PhosphorylationYSVGPLHSDLEYTVT
EEECCCCCCEEEEEE		52.12-
849PhosphorylationPLHSDLEYTVTSQKE
CCCCCEEEEEECCCC		17.51-
855UbiquitinationEYTVTSQKEGYVLTA
EEEEECCCCCEEEEE		53.53-
858PhosphorylationVTSQKEGYVLTAVEG
EECCCCCEEEEEEEE		8.0620068231
861PhosphorylationQKEGYVLTAVEGTIG
CCCCEEEEEEEEECC		20.7220068231
927UbiquitinationSPGQYYFKPMMKEFR
CCCCEEECCCCCEEC		18.84-
931UbiquitinationYYFKPMMKEFRFEPS
EEECCCCCEECCCCC		47.66-
941SulfoxidationRFEPSSQMIEVQEGQ
CCCCCCCEEEEECCC		2.8121406390
1019UbiquitinationCVYHVQLKAEGNDHI
CEEEEEEEECCCCHH		27.57-
1079UbiquitinationTLWVKLYKSENLDNP
EEEEEEHHCCCCCCC		62.83-
1110PhosphorylationLLRDGENYVVLLDST
CCCCCCCEEEEEECC		6.40-
1123PhosphorylationSTLPRSQYDYILPQV
CCCCHHHCCEEECCC		16.38-
1125PhosphorylationLPRSQYDYILPQVSF
CCHHHCCEEECCCEE		10.22-
1137PhosphorylationVSFTAVGYHKHITLI
CEEEEEEECCEEEEE		10.90-
1202PhosphorylationGALGQAASDNSGPED
CHHHHHHHCCCCHHH		40.1030266825
1205PhosphorylationGQAASDNSGPEDAKR
HHHHHCCCCHHHHHH		61.7930266825
1211UbiquitinationNSGPEDAKRQAKKQK
CCCHHHHHHHHHHHH		58.3221890473
1211AcetylationNSGPEDAKRQAKKQK
CCCHHHHHHHHHHHH		58.3226051181
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOMO3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOMO3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOMO3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NOMO3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOMO3_HUMAN

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Related Literatures of Post-Translational Modification

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