dbPTM

SPHM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPHM_HUMAN
UniProt AC	P51688
Protein Name	N-sulphoglucosamine sulphohydrolase
Gene Name	SGSH
Organism	Homo sapiens (Human).
Sequence Length	502
Subcellular Localization	Lysosome .
Protein Description	Catalyzes a step in lysosomal heparan sulfate degradation..
Protein Sequence	MSCPVPACCALLLVLGLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	N-linked_Glycosylation	GFESGAYNNSAIATP CCCCCCCCCCCCCCC	35.13	12754519
70	3-oxoalanine (Cys)	AFTSVSSCSPSRASL CCCCHHHCCHHHHHH	5.59	-
70	Oxidation	AFTSVSSCSPSRASL CCCCHHHCCHHHHHH	5.59	24816101
89	Phosphorylation	PQHQNGMYGLHQDVH CHHCCCCCCCCCCCC	20.24	25627689
103	Ubiquitination	HHFNSFDKVRSLPLL CCCCCHHHHHHHHHH	37.22	21890473
123	Ubiquitination	VRTGIIGKKHVGPET CCCCCCCCCCCCCCC	29.33	32015554
142	N-linked_Glycosylation	DFAYTEENGSVLQVG CEEEECCCCCEEEEC	41.63	UniProtKB CARBOHYD
151	N-linked_Glycosylation	SVLQVGRNITRIKLL CEEEECCCHHHHHHH	33.77	24816101
174	Phosphorylation	DDRPFFLYVAFHDPH CCCCEEEEEEECCCC	5.65	-
240	Phosphorylation	RADLAAQYTTVGRMD HHHHHHHHCCCCCCH	10.31	29759185
241	Phosphorylation	ADLAAQYTTVGRMDQ HHHHHHHCCCCCCHH	11.70	-
264	N-linked_Glycosylation	LRDAGVLNDTLVIFT HHHCCCCCCEEEEEE	37.50	12754519
264	N-linked_Glycosylation	LRDAGVLNDTLVIFT HHHCCCCCCEEEEEE	37.50	12754519
303	Ubiquitination	VSSPEHPKRWGQVSE ECCCCCCCHHHCCHH	63.79	21890473
330	Phosphorylation	LDWFSIPYPSYAIFG HHHHCCCCCCEEECC	11.79	-
332	Phosphorylation	WFSIPYPSYAIFGSK HHCCCCCCEEECCCE	22.73	23879269
333	Phosphorylation	FSIPYPSYAIFGSKT HCCCCCCEEECCCEE	10.14	23879269
407	Phosphorylation	QDFYVSPTFQDLLNR CCEEECCHHHHHHHC	26.82	-
413	N-linked_Glycosylation	PTFQDLLNRTTAGQP CHHHHHHHCCCCCCC	46.69	24816101
425	Ubiquitination	GQPTGWYKDLRHYYY CCCCCHHHHHHHHHH	43.72	21890473
448	Phosphorylation	RSRDPHETQNLATDP CCCCHHHHCCCCCCH	21.52	28851738
453	Phosphorylation	HETQNLATDPRFAQL HHHCCCCCCHHHHHH	50.10	28851738

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPHM_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPHM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPHM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SPHM_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
252900	Mucopolysaccharidosis 3A (MPS3A)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPHM_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-41 AND ASN-413, AND MASSSPECTROMETRY.	19159218 [Abstract]
"Identification and quantification of N-linked glycoproteins usinghydrazide chemistry, stable isotope labeling and mass spectrometry."; Zhang H., Li X.-J., Martin D.B., Aebersold R.; Nat. Biotechnol. 21:660-666(2003). Cited for: GLYCOSYLATION AT ASN-41 AND ASN-264.	12754519 [Abstract]