ENTP6_HUMAN - dbPTM
ENTP6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ENTP6_HUMAN
UniProt AC O75354
Protein Name Ectonucleoside triphosphate diphosphohydrolase 6
Gene Name ENTPD6
Organism Homo sapiens (Human).
Sequence Length 484
Subcellular Localization Golgi apparatus membrane
Single-pass type II membrane protein. Secreted. But also occurs in a soluble extracellular form.
Protein Description Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity)..
Protein Sequence MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQKSPAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationRYETSRKTSYIFQQP
EEECCCCCEEEECCC		26.1729978859
14PhosphorylationYETSRKTSYIFQQPQ
EECCCCCEEEECCCC		21.1929978859
15PhosphorylationETSRKTSYIFQQPQH
ECCCCCEEEECCCCC		15.8129978859
27PhosphorylationPQHGPWQTRMRKISN
CCCCCHHHHCHHHCC		23.6729978859
31UbiquitinationPWQTRMRKISNHGSL
CHHHHCHHHCCCCCH		40.94-
33PhosphorylationQTRMRKISNHGSLRV
HHHCHHHCCCCCHHH		26.3029853039
45PhosphorylationLRVAKVAYPLGLCVG
HHHHCHHHHHHHHHH		11.2825884760
73PhosphorylationTATQAFFSITRAAPG
CHHHHHHHHHCCCCC		19.3224719451
89O-linked_GlycosylationRWGQQAHSPLGTAAD
CCCCCCCCCCCCCCC		25.4955827893
93O-linked_GlycosylationQAHSPLGTAADGHEV
CCCCCCCCCCCCCEE		26.7655827899
129O-linked_GlycosylationRPPRETPTLTHETFK
CCCCCCCCCCHHHHH		52.27OGP
136MethylationTLTHETFKALKPGLS
CCCHHHHHHHCCCHH		61.30-
138UbiquitinationTHETFKALKPGLSAY
CHHHHHHHCCCHHHC		7.6821906983
138UbiquitinationTHETFKALKPGLSAY
CHHHHHHHCCCHHHC		7.6821906983
139UbiquitinationHETFKALKPGLSAYA
HHHHHHHCCCHHHCH		41.7321906983
164UbiquitinationRELLDVAKQDIPFDF
HHHHHHHHCCCCCCH		48.64-
173UbiquitinationDIPFDFWKATPLVLK
CCCCCHHHCCHHHHH		42.23-
175PhosphorylationPFDFWKATPLVLKAT
CCCHHHCCHHHHHHC		17.2724173317
192UbiquitinationLRLLPGEKAQKLLQK
CCCCCHHHHHHHHHH		63.13-
220N-linked_GlycosylationDDCVSIMNGTDEGVS
CCEEEECCCCCCCCE		48.8414529283
238PhosphorylationTINFLTGSLKTPGGS
EEEEHHCCCCCCCCC		22.8119007248
272O-linked_GlycosylationVEGTLQASPPGYLTA
CEECEECCCCCHHHH		20.75OGP
278PhosphorylationASPPGYLTALRMFNR
CCCCCHHHHHHHHCC		18.3724719451
284N-linked_GlycosylationLTALRMFNRTYKLYS
HHHHHHHCCCEEECC		26.4914529283
290PhosphorylationFNRTYKLYSYSYLGL
HCCCEEECCCCHHCH		11.0425262027
291PhosphorylationNRTYKLYSYSYLGLG
CCCEEECCCCHHCHH		20.3125262027
292PhosphorylationRTYKLYSYSYLGLGL
CCEEECCCCHHCHHH		6.4325262027
293PhosphorylationTYKLYSYSYLGLGLM
CEEECCCCHHCHHHH		14.1325262027
294PhosphorylationYKLYSYSYLGLGLMS
EEECCCCHHCHHHHH		9.1425262027
301PhosphorylationYLGLGLMSARLAILG
HHCHHHHHHHHHHHC		18.4525262027
315UbiquitinationGGVEGQPAKDGKELV
CCCCCCCCCCCCCCC		18.0621906983
316UbiquitinationGVEGQPAKDGKELVS
CCCCCCCCCCCCCCC		73.9421906983
344PhosphorylationAEVTYRVSGQKAAAS
EEEEEEECCHHHHHH		26.89-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ENTP6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ENTP6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ENTP6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ENTP6_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ENTP6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.

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