MGT5A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGT5A_HUMAN
• UniProt AC: Q09328
• Protein Name: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
• Gene Name: MGAT5
• Organism: Homo sapiens (Human).
• Sequence Length: 741
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides..
• Protein Sequence: MALFTPWKLSSQKLGFFLVTFGFIWGMMLLHFTIQQRTQPESSSMLREQILDLSKRYIKALAEENRNVVDGPYAGVMTAYDLKKTLAVLLDNILQRIGKLESKVDNLVVNGTGTNSTNSTTAVPSLVALEKINVADIINGAQEKCVLPPMDGYPHCEGKIKWMKDMWRSDPCYADYGVDGSTCSFFIYLSEVENWCPHLPWRAKNPYEEADHNSLAEIRTDFNILYSMMKKHEEFRWMRLRIRRMADAWIQAIKSLAEKQNLEKRKRKKVLVHLGLLTKESGFKIAETAFSGGPLGELVQWSDLITSLYLLGHDIRISASLAELKEIMKKVVGNRSGCPTVGDRIVELIYIDIVGLAQFKKTLGPSWVHYQCMLRVLDSFGTEPEFNHANYAQSKGHKTPWGKWNLNPQQFYTMFPHTPDNSFLGFVVEQHLNSSDIHHINEIKRQNQSLVYGKVDSFWKNKKIYLDIIHTYMEVHATVYGSSTKNIPSYVKNHGILSGRDLQFLLRETKLFVGLGFPYEGPAPLEAIANGCAFLNPKFNPPKSSKNTDFFIGKPTLRELTSQHPYAEVFIGRPHVWTVDLNNQEEVEDAVKAILNQKIEPYMPYEFTCEGMLQRINAFIEKQDFCHGQVMWPPLSALQVKLAEPGQSCKQVCQESQLICEPSFFQHLNKDKDMLKYKVTCQSSELAKDILVPSFDPKNKHCVFQGDLLLFSCAGAHPRHQRVCPCRDFIKGQVALCKDCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Acetylation	EQILDLSKRYIKALA HHHHHHHHHHHHHHH	57.42	19816855
55	Ubiquitination	EQILDLSKRYIKALA HHHHHHHHHHHHHHH	57.42	29967540
57	Phosphorylation	ILDLSKRYIKALAEE HHHHHHHHHHHHHHH	15.54	22817900
80	Phosphorylation	YAGVMTAYDLKKTLA CCCEEEHHHHHHHHH	16.79	22817900
83	Ubiquitination	VMTAYDLKKTLAVLL EEEHHHHHHHHHHHH	40.59	32015554
84	Ubiquitination	MTAYDLKKTLAVLLD EEHHHHHHHHHHHHH	56.94	-
85	O-linked_Glycosylation	TAYDLKKTLAVLLDN EHHHHHHHHHHHHHH	20.54	OGP
110	N-linked_Glycosylation	KVDNLVVNGTGTNST HCCEEEECCCCCCCC	34.53	UniProtKB CARBOHYD
115	N-linked_Glycosylation	VVNGTGTNSTNSTTA EECCCCCCCCCCCCC	48.45	UniProtKB CARBOHYD
118	N-linked_Glycosylation	GTGTNSTNSTTAVPS CCCCCCCCCCCCCCC	36.86	UniProtKB CARBOHYD
121	O-linked_Glycosylation	TNSTNSTTAVPSLVA CCCCCCCCCCCCEEE	26.02	OGP
220	Phosphorylation	NSLAEIRTDFNILYS CCHHHHHHHHHHHHH	51.08	-
226	Phosphorylation	RTDFNILYSMMKKHE HHHHHHHHHHHHHCC	7.25	-
227	Phosphorylation	TDFNILYSMMKKHEE HHHHHHHHHHHHCCC	14.68	-
278	Phosphorylation	LVHLGLLTKESGFKI HHHHHHCCCCCCCEE	37.50	-
334	N-linked_Glycosylation	IMKKVVGNRSGCPTV HHHHHHCCCCCCCCH	24.28	UniProtKB CARBOHYD
350	Phosphorylation	DRIVELIYIDIVGLA HHHEEEEEEEHHHHH	12.74	27762562
362	Phosphorylation	GLAQFKKTLGPSWVH HHHHHHHHHCCHHHH	37.22	27762562
433	N-linked_Glycosylation	FVVEQHLNSSDIHHI HHHHHHCCCCCCCCH	37.02	30140003
447	N-linked_Glycosylation	INEIKRQNQSLVYGK HHHHHHHCCCCEECE	37.12	UniProtKB CARBOHYD
452	Phosphorylation	RQNQSLVYGKVDSFW HHCCCCEECEECHHH	19.27	23186163
462	Acetylation	VDSFWKNKKIYLDII ECHHHHCCEEEHHHH	36.50	6570513
463	Acetylation	DSFWKNKKIYLDIIH CHHHHCCEEEHHHHH	46.08	2401697
544	Phosphorylation	PKFNPPKSSKNTDFF CCCCCCCCCCCCCCE	52.93	30387612
545	Phosphorylation	KFNPPKSSKNTDFFI CCCCCCCCCCCCCEE	35.73	-
548	Phosphorylation	PPKSSKNTDFFIGKP CCCCCCCCCCEECCC	37.61	-
554	Ubiquitination	NTDFFIGKPTLRELT CCCCEECCCHHHHHH	29.97	-
556	Phosphorylation	DFFIGKPTLRELTSQ CCEECCCHHHHHHHC	41.77	-
602	Phosphorylation	LNQKIEPYMPYEFTC HHCCCCCCCCCEECH	9.64	32142685
608	Phosphorylation	PYMPYEFTCEGMLQR CCCCCEECHHHHHHH	9.56	32142685
648	Phosphorylation	KLAEPGQSCKQVCQE HCCCCCCHHHHHHHH	29.24	30001349
680	Phosphorylation	DMLKYKVTCQSSELA CHHHEEEEECCHHHH	10.73	29759185
683	Phosphorylation	KYKVTCQSSELAKDI HEEEEECCHHHHHHC	28.11	29759185
684	Phosphorylation	YKVTCQSSELAKDIL EEEEECCHHHHHHCC	15.68	29759185
694	Phosphorylation	AKDILVPSFDPKNKH HHHCCCCCCCCCCCC	34.50	29759185
712	Phosphorylation	QGDLLLFSCAGAHPR ECCEEEEECCCCCCC	11.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGT5A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGT5A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGT5A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MGT5A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.