ITA8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITA8_HUMAN
• UniProt AC: P53708
• Protein Name: Integrin alpha-8
• Gene Name: ITGA8
• Organism: Homo sapiens (Human).
• Sequence Length: 1063
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Cell membrane .
• Protein Description: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons..
• Protein Sequence: MSPGASRGPRGSQAPLIAPLCCAAAALGMLLWSPACQAFNLDVEKLTVYSGPKGSYFGYAVDFHIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVKAHKGKVVACAPLYHWRTLKPTPEKDPVGTCYVAIQNFSAYAEFSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITASVADIIANYSFKDILRKLAGEKQTEVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFESNPREVGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNKDGLNTKPSQVLQGVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLDSLKQKGAIKRTLFLDNHQAHRVFPLVIKRQKSHQCQDFIVYLRDETEFRDKLSPINISLNYSLDESTFKEGLEVKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTNDKTPEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPGASRGP ------CCCCCCCCC	43.26	15302935
72	Phosphorylation	IPDARTASVLVGAPK CCCCCCCEEEECCCC	18.51	25884760
81	N-linked_Glycosylation	LVGAPKANTSQPDIV EECCCCCCCCCCCCE	46.52	UniProtKB CARBOHYD
122	N-linked_Glycosylation	NNRKIRVNGTKEPIE CCCEEEECCCCCCEE	42.44	UniProtKB CARBOHYD
177	N-linked_Glycosylation	TCYVAIQNFSAYAEF EEEEEEECCEEEEEC	27.08	UniProtKB CARBOHYD
239	N-linked_Glycosylation	SVADIIANYSFKDIL EHHHHHHCCCHHHHH	23.67	UniProtKB CARBOHYD
302	N-linked_Glycosylation	FGYVSIINSTDMTFI CCEEEEEECCCCCEE	36.87	UniProtKB CARBOHYD
311	N-linked_Glycosylation	TDMTFIQNFTGEQMA CCCCEEECCCCHHHH	31.47	UniProtKB CARBOHYD
367	O-linked_Glycosylation	IYLYLQVSSLLFRDP HEEEHHHHHHHHCCC	11.42	29351928
368	O-linked_Glycosylation	YLYLQVSSLLFRDPQ EEEHHHHHHHHCCCC	30.18	29351928
378	Phosphorylation	FRDPQILTGTETFGR HCCCCCCCCCCCCHH	43.62	22817900
418	Ubiquitination	AGKDQRGKVLIYNGN CCCCCCCCEEEECCC	35.74	21906983
422	Phosphorylation	QRGKVLIYNGNKDGL CCCCEEEECCCCCCC	16.92	29052541
453	Phosphorylation	VPSGFGFTLRGDSDI CCCCCCEEEECCCCC	18.87	24719451
481	Phosphorylation	GTGKVAVYRARPVVT CCCCEEEEECCCEEE	6.71	-
504	N-linked_Glycosylation	PMIINLENKTCQVPD CEEEECCCCCCCCCC	48.37	UniProtKB CARBOHYD
556	Phosphorylation	QKGAIKRTLFLDNHQ HCCCCCEEEEECCCC	19.50	24043423
573	Ubiquitination	RVFPLVIKRQKSHQC HHHCEEEECCCCCCC	41.10	21906983
601	N-linked_Glycosylation	RDKLSPINISLNYSL HHHCCCEEEEECCCC	22.60	UniProtKB CARBOHYD
605	N-linked_Glycosylation	SPINISLNYSLDEST CCEEEEECCCCCCCC	19.98	UniProtKB CARBOHYD
614	Acetylation	SLDESTFKEGLEVKP CCCCCCCCCCCEEHH	51.46	11794795
620	Acetylation	FKEGLEVKPILNYYR CCCCCEEHHHHHHHH	19.57	11792759
719	N-linked_Glycosylation	SCEYKMENVTRMVVC CCEEECCCEEEEEEE	36.64	UniProtKB CARBOHYD
737	N-linked_Glycosylation	NPMVSGTNYSLGLRF CCCCCCCCCCCEEEE	28.11	UniProtKB CARBOHYD
751	Ubiquitination	FAVPRLEKTNMSINF EEEECEEECCCEEEE	50.20	-
753	N-linked_Glycosylation	VPRLEKTNMSINFDL EECEEECCCEEEEEE	33.02	UniProtKB CARBOHYD
767	Ubiquitination	LQIRSSNKDNPDSNF EEEECCCCCCCCCCC	61.91	-
780	N-linked_Glycosylation	NFVSLQINITAVAQV CCEEEEEEEEEEEEE	16.76	UniProtKB CARBOHYD
896	N-linked_Glycosylation	ELSAFLRNSTIPHLV HHHHHHHCCCCCHHH	45.73	UniProtKB CARBOHYD
923	N-linked_Glycosylation	QSPAKILNCTNIECL CCCCHHHCCCCCEEE	33.76	UniProtKB CARBOHYD
948	Ubiquitination	GGESAVLKVRSRLWA CCCCCHHHHHHHHHH	29.07	21906983
966	Phosphorylation	LQRKNDPYALASLVS HHHCCCHHHHHHHEE	19.67	22210691
970	Phosphorylation	NDPYALASLVSFEVK CCHHHHHHHEEEEEE	30.10	22210691
973	Phosphorylation	YALASLVSFEVKKMP HHHHHHEEEEEEECC	22.45	22210691
997	O-linked_Glycosylation	EGSIVIKTSVIWATP CCCEEEEEEEEECCC	19.66	29351928
998	O-linked_Glycosylation	GSIVIKTSVIWATPN CCEEEEEEEEECCCC	13.45	29351928
1005	N-linked_Glycosylation	SVIWATPNVSFSIPL EEEECCCCCCCHHHH	37.40	UniProtKB CARBOHYD
1056	Phosphorylation	MTDREQLTNDKTPEA CCCHHHHHCCCCCCC	40.85	26471730
1060	Phosphorylation	EQLTNDKTPEA---- HHHHCCCCCCC----	29.26	26471730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITA8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITA8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITA8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPNT_HUMAN	NPNT	physical	11470831

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• 191830: Renal hypodysplasia/aplasia 1 (RHDA1)
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.