NPNT_HUMAN - dbPTM
NPNT_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NPNT_HUMAN
UniProt AC Q6UXI9
Protein Name Nephronectin
Gene Name NPNT
Organism Homo sapiens (Human).
Sequence Length 565
Subcellular Localization Secreted, extracellular space, extracellular matrix. Trapped on the cell surface or in the extracellular matrix..
Protein Description Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity)..
Protein Sequence MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRTPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQKPRGDVFIPRQPSNDLFEIFEIERGVSADDEAKDDPGVLVHSCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGEKRRGHTGEIGLDDVSLKKGHCSEER
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationLLALVLVSSLYLQAA
HHHHHHHHHHHHHHH		15.5124043423
12PhosphorylationLALVLVSSLYLQAAA
HHHHHHHHHHHHHHH		17.3524043423
14PhosphorylationLVLVSSLYLQAAAEF
HHHHHHHHHHHHHHC		9.9424043423
74UbiquitinationGECIGPNKCKCHPGY
CCEECCCCCCCCCCC		37.9029967540
91UbiquitinationKTCNQDLNECGLKPR
CCCCCCHHHCCCCCC		51.2929967540
96UbiquitinationDLNECGLKPRPCKHR
CHHHCCCCCCCCCCC		25.0229967540
96MethylationDLNECGLKPRPCKHR
CHHHCCCCCCCCCCC		25.0223644510
96TrimethylationDLNECGLKPRPCKHR
CHHHCCCCCCCCCCC		25.02-
113UbiquitinationNTYGSYKCYCLNGYM
CCCCCCEEEEECCEE		1.8929967540
114PhosphorylationTYGSYKCYCLNGYML
CCCCCEEEEECCEEE		8.8824043423
119PhosphorylationKCYCLNGYMLMPDGS
EEEEECCEEECCCCC		5.9924043423
126PhosphorylationYMLMPDGSCSSALTC
EEECCCCCCCCCHHH		20.4324043423
128PhosphorylationLMPDGSCSSALTCSM
ECCCCCCCCCHHHHH		21.9724043423
129PhosphorylationMPDGSCSSALTCSMA
CCCCCCCCCHHHHHC		31.4624043423
132PhosphorylationGSCSSALTCSMANCQ
CCCCCCHHHHHCCCC		11.4024043423
134PhosphorylationCSSALTCSMANCQYG
CCCCHHHHHCCCCCC		18.7224043423
140PhosphorylationCSMANCQYGCDVVKG
HHHCCCCCCCCEECC		23.1724043423
189PhosphorylationRFRQCVNTFGSYICK
HHHHHHHHHHHHHHH		14.6924719451
205PhosphorylationHKGFDLMYIGGKYQC
CCCCCEEEECCEEEE		12.0524719451
223PhosphorylationDECSLGQYQCSSFAR
CCCCCCEEECCCCCH		15.08-
226PhosphorylationSLGQYQCSSFARCYN
CCCEEECCCCCHHEE		16.99-
227PhosphorylationLGQYQCSSFARCYNI
CCEEECCCCCHHEEC		30.47-
258UbiquitinationLTCVYIPKVMIEPSG
EEEEEECCEEEECCC		34.5729967540
264O-linked_GlycosylationPKVMIEPSGPIHVPK
CCEEEECCCCEECCC		44.4055832555
275UbiquitinationHVPKGNGTILKGDTG
ECCCCCCEEEECCCC		27.4329967540
288UbiquitinationTGNNNWIPDVGSTWW
CCCCCCCCCCCCCCC		23.1129967540
327O-linked_GlycosylationPKPTPIPTPPPPPPL
CCCCCCCCCCCCCCC		49.50OGP
336PhosphorylationPPPPPLPTELRTPLP
CCCCCCCCCCCCCCC		56.1624719451
362O-linked_GlycosylationTTIAPAASTPPGGIT
CEEECCCCCCCCCEE		43.48OGP
363O-linked_GlycosylationTIAPAASTPPGGITV
EEECCCCCCCCCEEE		28.86OGP
376O-linked_GlycosylationTVDNRVQTDPQKPRG
EECCCEECCCCCCCC		46.9555830883
380UbiquitinationRVQTDPQKPRGDVFI
CEECCCCCCCCCEEC		41.9129967540
392PhosphorylationVFIPRQPSNDLFEIF
EECCCCCCCCCEEEE		34.3424719451
397UbiquitinationQPSNDLFEIFEIERG
CCCCCCEEEEEEECC		54.8129967540
410UbiquitinationRGVSADDEAKDDPGV
CCCCCCCCCCCCCCE		59.1629967540
422PhosphorylationPGVLVHSCNFDHGLC
CCEEEEECCCCCCCC		3.3824719451
430UbiquitinationNFDHGLCGWIREKDN
CCCCCCCHHHEECCC		28.0829967540
459UbiquitinationYLTVSAAKAPGGKAA
EEEEEEECCCCCHHH		55.6329967540
460UbiquitinationLTVSAAKAPGGKAAR
EEEEEECCCCCHHHE		11.8429967540
476UbiquitinationVLPLGRLMHSGDLCL
EEEHHHHHHCCCEEE		1.9729967540
489UbiquitinationCLSFRHKVTGLHSGT
EEEEEEECCCCCCCE		4.1329967540
528UbiquitinationRQTQITLRGADIKSV
EEEEEEECCCCEEEE		29.6029967540
557UbiquitinationGLDDVSLKKGHCSEE
CCCCCCCCCCCCCCC		49.5629967540
558UbiquitinationLDDVSLKKGHCSEER
CCCCCCCCCCCCCCC		60.2129967540
574Ubiquitination----------------
----------------		29967540
587Ubiquitination-----------------------------
-----------------------------		29967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NPNT_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NPNT_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NPNT_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ITA8_HUMANITGA8physical
11470831
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NPNT_HUMAN

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Related Literatures of Post-Translational Modification

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