PLXA1_HUMAN - dbPTM
PLXA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLXA1_HUMAN
UniProt AC Q9UIW2
Protein Name Plexin-A1
Gene Name PLXNA1
Organism Homo sapiens (Human).
Sequence Length 1896
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)..
Protein Sequence MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQGQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFAGTRSGRIRKILVDLSNPGGRPALAYESVVAQEGSPILRDLVLSPNHQYLYAMTEKQVTRVPVESCVQYTSCELCLGSRDPHCGWCVLHSICSRRDACERADEPQRFAADLLQCVQLTVQPRNVSVTMSQVPLVLQAWNVPDLSAGVNCSFEDFTESESVLEDGRIHCRSPSAREVAPITRGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNVADCAFLEGRVNVSEDCPQILPSTQIYVPVGVVKPITLAARNLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDVSDLPVNLSVVWNGNFVIDNPQNIQAHLYKCPALRESCGLCLKADPRFECGWCVAERRCSLRHHCAADTPASWMHARHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRVGKVLCSPVESEYISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAGSDVAVSVGGRPCSFSWRNSREIRCLTPPGQSPGSAPIIININRAQLTNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGGIERENGCLVYNDTTMVCRAPSVANPVRSPPELGERPDELGFVMDNVRSLLVLNSTSFLYYPDPVLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPCTLTVSETQLLCEAPNLTGQHKVTVRAGGFEFSPGTLQVYSDSLLTLPAIVGIGGGGGLLLLVIVAVLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIEDHPVLKEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRSFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLNCVNPENENAPEVPVKGLDCDTVTQAKEKLLDAAYKGVPYSQRPKAADMDLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYESMLRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDADVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYITKYKDEILAALEKDEQARRQRLRSKLEQVVDTMALSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77N-linked_GlycosylationRIYKLSGNLTLLRAH
HEEEECCCEEEEEEE		26.8619349973
159PhosphorylationPHHRKEHYLSSVQEA
CCCCCHHHHHHHHHH		14.9022210691
161PhosphorylationHRKEHYLSSVQEAGS
CCCHHHHHHHHHHHC		22.6922210691
168PhosphorylationSSVQEAGSMAGVLIA
HHHHHHHCCCCEEEE		16.7122210691
194UbiquitinationVGTPIDGKSEYFPTL
EECCCCCCCCCCCCH		36.04-
361PhosphorylationESALCLFTLRAIKEK
HHHHHHHHHHHHHHH		11.4624719451
375PhosphorylationKIKERIQSCYRGEGK
HHHHHHHHHHCCCCC		15.6727794612
377PhosphorylationKERIQSCYRGEGKLS
HHHHHHHHCCCCCCC		27.2227794612
382UbiquitinationSCYRGEGKLSLPWLL
HHHCCCCCCCHHHHH		30.51-
629PhosphorylationAREVAPITRGQGDQR
HHHCCCCCCCCCCHH		27.9122210691
660N-linked_GlycosylationSVDFVFYNCSVHQSC
ECEEEEEECCCCHHH		10.50UniProtKB CARBOHYD
672N-linked_GlycosylationQSCLSCVNGSFPCHW
HHHHHHHCCCCCCCH		44.72UniProtKB CARBOHYD
701N-linked_GlycosylationAFLEGRVNVSEDCPQ
HHHCCCCCCCCCCCC		30.18UniProtKB CARBOHYD
726O-linked_GlycosylationVGVVKPITLAARNLP
CEEEECEEEHHCCCC		20.9055828069
751PhosphorylationCLFHIPGSPARVTAL
EEEECCCCCCEEEEE		15.2726699800
816S-palmitoylationCPALRESCGLCLKAD
CHHHHHHCCEECCCC		4.0629575903
819S-palmitoylationLRESCGLCLKADPRF
HHHHCCEECCCCCCC		1.9129575903
952PhosphorylationSPHYRALSPKRFTFV
CCCCHHCCCCCEEEE		27.6524719451
1041UbiquitinationQLTNPEVKYNYTEDP
HCCCCCCCCCCCCCC		26.5622817900
1043N-linked_GlycosylationTNPEVKYNYTEDPTI
CCCCCCCCCCCCCCE		31.3719349973
1059UbiquitinationRIDPEWSINSGGTLL
EECCCCEECCCCEEE		5.0822817900
1097PhosphorylationRENGCLVYNDTTMVC
EECCEEEEECCEEEE		8.38-
1167PhosphorylationLLELKPSSPLILKGR
CEEECCCCCEEEECC		32.0526437602
1187N-linked_GlycosylationAPGNSRLNYTVLIGS
CCCCCCCEEEEEECC		29.35UniProtKB CARBOHYD
1195O-linked_GlycosylationYTVLIGSTPCTLTVS
EEEEECCCCCEEEEE		19.71OGP
1212N-linked_GlycosylationQLLCEAPNLTGQHKV
EEEEECCCCCCCCEE		58.23UniProtKB CARBOHYD
1353UbiquitinationEVQANVEKSLTLFGQ
EECCHHHHHHHHHHH		46.62-
1380PhosphorylationRTLEAQRSFSMRDRG
HHHHHHHCCCCCCCC		15.0328165663
1382PhosphorylationLEAQRSFSMRDRGNV
HHHHHCCCCCCCCHH		17.7228165663
1391PhosphorylationRDRGNVASLIMTALQ
CCCCHHHHHHHHHHH		17.7228165663
1403PhosphorylationALQGEMEYATGVLKQ
HHHHHHHHHHHHHHH		14.25-
1418UbiquitinationLLSDLIEKNLESKNH
HHHHHHHHHHHCCCC		60.8923000965
1422PhosphorylationLIEKNLESKNHPKLL
HHHHHHHCCCCHHHH		41.7620886841
1423UbiquitinationIEKNLESKNHPKLLL
HHHHHHCCCCHHHHH		50.3123000965
1427UbiquitinationLESKNHPKLLLRRTE
HHCCCCHHHHHHCCH		44.19-
1436UbiquitinationLLRRTESVAEKMLTN
HHHCCHHHHHHHHHH		6.9321890473
1441UbiquitinationESVAEKMLTNWFTFL
HHHHHHHHHHHHHHH		5.0523000965
1454AcetylationFLLYKFLKECAGEPL
HHHHHHHHHHCCCCH		54.6119827757
1486PhosphorylationAITGEARYSLSEDKL
CCCCCEECCCCHHHH		22.4728102081
1487PhosphorylationITGEARYSLSEDKLI
CCCCEECCCCHHHHH		21.6228102081
1492UbiquitinationRYSLSEDKLIRQQID
ECCCCHHHHHHHHCC		41.59-
1500PhosphorylationLIRQQIDYKTLTLNC
HHHHHCCCCEEEEEC		13.91-
1501UbiquitinationIRQQIDYKTLTLNCV
HHHHCCCCEEEEECC		33.0529967540
1521UbiquitinationNAPEVPVKGLDCDTV
CCCCCCCCCCCCHHH		47.9229967540
1574PhosphorylationILQDEDVTTKIDNDW
EECCCCCCCCCCCCH		34.3925332170
1575PhosphorylationLQDEDVTTKIDNDWK
ECCCCCCCCCCCCHH		26.3325332170
1576UbiquitinationQDEDVTTKIDNDWKR
CCCCCCCCCCCCHHH		38.4029967540
1590PhosphorylationRLNTLAHYQVTDGSS
HHHCCEEEEECCCCC		10.0827642862
1597PhosphorylationYQVTDGSSVALVPKQ
EEECCCCCEEEEECC		19.55-
1605PhosphorylationVALVPKQTSAYNISN
EEEEECCCCCCCCCC		22.8121945579
1606PhosphorylationALVPKQTSAYNISNS
EEEECCCCCCCCCCC		26.6821945579
1608PhosphorylationVPKQTSAYNISNSST
EECCCCCCCCCCCHH		16.8821945579
1611PhosphorylationQTSAYNISNSSTFTK
CCCCCCCCCCHHHHH		27.3321945579
1613PhosphorylationSAYNISNSSTFTKSL
CCCCCCCCHHHHHHH		24.7821945579
1614PhosphorylationAYNISNSSTFTKSLS
CCCCCCCHHHHHHHH		31.6121945579
1615PhosphorylationYNISNSSTFTKSLSR
CCCCCCHHHHHHHHH		34.8325849741
1617PhosphorylationISNSSTFTKSLSRYE
CCCCHHHHHHHHHHH		21.5821945579
1618UbiquitinationSNSSTFTKSLSRYES
CCCHHHHHHHHHHHH		45.2523000965
1619PhosphorylationNSSTFTKSLSRYESM
CCHHHHHHHHHHHHH		28.6428796482
1621PhosphorylationSTFTKSLSRYESMLR
HHHHHHHHHHHHHHH		39.6528796482
1623PhosphorylationFTKSLSRYESMLRTA
HHHHHHHHHHHHHHC		14.6928796482
1625PhosphorylationKSLSRYESMLRTASS
HHHHHHHHHHHHCCC		17.7428796482
1629PhosphorylationRYESMLRTASSPDSL
HHHHHHHHCCCCHHH		27.2529396449
1631PhosphorylationESMLRTASSPDSLRS
HHHHHHCCCCHHHHC		41.6228176443
1632PhosphorylationSMLRTASSPDSLRSR
HHHHHCCCCHHHHCC		30.2025159151
1635PhosphorylationRTASSPDSLRSRTPM
HHCCCCHHHHCCCCC		29.1225159151
1636UbiquitinationTASSPDSLRSRTPMI
HCCCCHHHHCCCCCC		8.2123000965
1638PhosphorylationSSPDSLRSRTPMITP
CCCHHHHCCCCCCCC		45.8830576142
1642SulfoxidationSLRSRTPMITPDLES
HHHCCCCCCCCCCHH		5.4321406390
1651PhosphorylationTPDLESGTKLWHLVK
CCCCHHCCCHHHHHH		32.0422210691
1672PhosphorylationQREGDRGSKMVSEIY
HCCCCHHHHHHHHHH		20.6224719451
1679PhosphorylationSKMVSEIYLTRLLAT
HHHHHHHHHHHHHCC		9.66-
1687UbiquitinationLTRLLATKGTLQKFV
HHHHHCCHHHHHHHH		44.2729967540
1769PhosphorylationDIHKNSITDACLSVV
EECCCCHHHHHHHHH		19.8429116813
1793UbiquitinationTSEHKLGKDSPSNKL
CCCCCCCCCCCCCCE		66.5229967540
1797PhosphorylationKLGKDSPSNKLLYAK
CCCCCCCCCCEEEEC		51.0228857561
1799UbiquitinationGKDSPSNKLLYAKDI
CCCCCCCCEEEECCC		44.1829967540
1804UbiquitinationSNKLLYAKDIPNYKS
CCCEEEECCCCCHHH		42.5129967540
1817PhosphorylationKSWVERYYADIAKMP
HHHHHHHHHHHHCCC		12.20-
1863UbiquitinationYSYITKYKDEILAAL
HHHHHHCHHHHHHHH		50.9029967540
1872UbiquitinationEILAALEKDEQARRQ
HHHHHHHHHHHHHHH		68.3729967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1608YPhosphorylationKinaseFYNP06241
PSP
1679YPhosphorylationKinaseFYNP06241
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLXA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLXA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AKT1_HUMANAKT1physical
15187088
PLXA1_HUMANPLXNA1physical
15187088
PLXA1_HUMANPLXNA1physical
11239433
NRP1_HUMANNRP1physical
11239433
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLXA1_HUMAN

loading...

Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-77 AND ASN-1043, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory