B3GLT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B3GLT_HUMAN
• UniProt AC: Q6Y288
• Protein Name: Beta-1,3-glucosyltransferase
• Gene Name: B3GLCT {ECO:0000312|HGNC:HGNC:20207}
• Organism: Homo sapiens (Human).
• Sequence Length: 498
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
• Protein Description: O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan..
• Protein Sequence: MRPPACWWLLAPPALLALLTCSLAFGLASEDTKKEVKQSQDLEKSGISRKNDIDLKGIVFVIQSQSNSFHAKRAEQLKKSILKQAADLTQELPSVLLLHQLAKQEGAWTILPLLPHFSVTYSRNSSWIFFCEEETRIQIPKLLETLRRYDPSKEWFLGKALHDEEATIIHHYAFSENPTVFKYPDFAAGWALSIPLVNKLTKRLKSESLKSDFTIDLKHEIALYIWDKGGGPPLTPVPEFCTNDVDFYCATTFHSFLPLCRKPVKKKDIFVAVKTCKKFHGDRIPIVKQTWESQASLIEYYSDYTENSIPTVDLGIPNTDRGHCGKTFAILERFLNRSQDKTAWLVIVDDDTLISISRLQHLLSCYDSGEPVFLGERYGYGLGTGGYSYITGGGGMVFSREAVRRLLASKCRCYSNDAPDDMVLGMCFSGLGIPVTHSPLFHQARPVDYPKDYLSHQVPISFHKHWNIDPVKVYFTWLAPSDEDKARQETQKGFREEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Ubiquitination	QSNSFHAKRAEQLKK CCCCHHHHHHHHHHH	43.50	-
80	Phosphorylation	RAEQLKKSILKQAAD HHHHHHHHHHHHHHH	31.40	24719451
275	Phosphorylation	DIFVAVKTCKKFHGD CEEEEEECCHHHCCC	23.98	25690035
336	N-linked_Glycosylation	AILERFLNRSQDKTA HHHHHHHCCCCCCCE	38.55	UniProtKB CARBOHYD
352	Phosphorylation	LVIVDDDTLISISRL EEEECCCCEEEHHHH	32.74	23532336
357	Phosphorylation	DDTLISISRLQHLLS CCCEEEHHHHHHHHH	21.83	-
443	Ubiquitination	THSPLFHQARPVDYP CCCCCCCCCCCCCCC	31.56	24816145
452	Ubiquitination	RPVDYPKDYLSHQVP CCCCCCHHHHHCCCC	45.13	24816145
473	Ubiquitination	WNIDPVKVYFTWLAP CCCCCEEEEEEEECC	4.90	24816145
481	Phosphorylation	YFTWLAPSDEDKARQ EEEEECCCCHHHHHH	48.28	-
492	Ubiquitination	KARQETQKGFREEL- HHHHHHHHHHHHHC-	68.39	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B3GLT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B3GLT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B3GLT_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of B3GLT_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.