LMLN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMLN_HUMAN
• UniProt AC: Q96KR4
• Protein Name: Leishmanolysin-like peptidase
• Gene Name: LMLN
• Organism: Homo sapiens (Human).
• Sequence Length: 655
• Subcellular Localization: Cytoplasm. Lipid droplet. Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells.
• Protein Description: Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration..
• Protein Sequence: MVTTLGPKMAAEWGGGVGYSGSGPGRSRWRWSGSVWVRSVLLLLGGLRASATSTPVSLGSSPPCRHHVPSDTEVINKVHLKANHVVKRDVDEHLRIKTVYDKSVEELLPEKKNLVKNKLFPQAISYLEKTFQVRRPAGTILLSRQCATNQYLRKENDPHRYCTGECAAHTKCGPVIVPEEHLQQCRVYRGGKWPHGAVGVPDQEGISDADFVLYVGALATERCSHENIISYAAYCQQEANMDRPIAGYANLCPNMISTQPQEFVGMLSTVKHEVIHALGFSAGLFAFYHDKDGNPLTSRFADGLPPFNYSLGLYQWSDKVVRKVERLWDVRDNKIVRHTVYLLVTPRVVEEARKHFDCPVLEGMELENQGGVGTELNHWEKRLLENEAMTGSHTQNRVLSRITLALMEDTGRQMLSPYCDTLRSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELSGIPAEDLPYYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRILENQPEIFKNYGAEKYGPHSVCLIQKSAFVMEKCERKLSYPDWGSGCYQVSCSPQGLKVWVQDTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFCELCPPETDPPATNLTRALPLDLCSCSSSLVVTLWLLLGNLFPLLAGFLLCIWH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	WGGGVGYSGSGPGRS CCCCCCCCCCCCCCC	22.13	29759185
22	Phosphorylation	GGVGYSGSGPGRSRW CCCCCCCCCCCCCCC	35.55	29759185
27	Phosphorylation	SGSGPGRSRWRWSGS CCCCCCCCCCCCCCC	41.95	29759185
98	Phosphorylation	DEHLRIKTVYDKSVE HHHCCEEEEECCCHH	23.17	21712546
139	Phosphorylation	QVRRPAGTILLSRQC CCCCCCCEEEEEEEH	15.57	-
143	Phosphorylation	PAGTILLSRQCATNQ CCCEEEEEEEHHHHH	19.50	-
151	Phosphorylation	RQCATNQYLRKENDP EEHHHHHHHHHCCCC	15.56	-
161	Phosphorylation	KENDPHRYCTGECAA HCCCCCCCCCCCCCC	7.42	-
163	Phosphorylation	NDPHRYCTGECAAHT CCCCCCCCCCCCCCC	27.38	-
170	Phosphorylation	TGECAAHTKCGPVIV CCCCCCCCCCCCEEC	24.25	-
298	Phosphorylation	KDGNPLTSRFADGLP CCCCCCCHHCCCCCC	32.84	-
314	Phosphorylation	FNYSLGLYQWSDKVV CCCEEEHHHCCHHHH	13.21	-
317	Phosphorylation	SLGLYQWSDKVVRKV EEEHHHCCHHHHHHH	16.42	-
339	Phosphorylation	DNKIVRHTVYLLVTP CCEEEEEEEEEEECH	10.57	29083192
341	Phosphorylation	KIVRHTVYLLVTPRV EEEEEEEEEEECHHH	8.75	29083192
345	Phosphorylation	HTVYLLVTPRVVEEA EEEEEEECHHHHHHH	12.83	24719451
348 (in isoform 2)	Phosphorylation	-	7.18	22210691
351 (in isoform 2)	Phosphorylation	-	42.01	22210691
365 (in isoform 2)	Phosphorylation	-	64.88	22210691
400 (in isoform 3)	Phosphorylation	-	20.84	22210691
401 (in isoform 2)	Phosphorylation	-	23.04	22210691
403 (in isoform 3)	Phosphorylation	-	12.60	22210691
417 (in isoform 3)	Phosphorylation	-	29.79	22210691
453 (in isoform 3)	Phosphorylation	-	32.44	22210691
514	Phosphorylation	QPEIFKNYGAEKYGP CCHHHHHCCCHHHCC	20.50	18083107
519	Phosphorylation	KNYGAEKYGPHSVCL HHCCCHHHCCCEEEE	27.65	18083107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMLN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMLN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMLN_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LMLN_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.