| UniProt ID | TECT1_HUMAN | |
|---|---|---|
| UniProt AC | Q2MV58 | |
| Protein Name | Tectonic-1 | |
| Gene Name | TCTN1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 587 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, cilium basal body. Secreted . Despite the presence of a signal sequence, the full-length protein might not be secreted. Localizes at the transition zone, a region between the basal body and the ciliary axoneme.. | |
| Protein Description | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity).. | |
| Protein Sequence | MRPRGLPPLLVVLLGCWASVSAQTDATPAVTTEGLNSTEAALATFGTFPSTRPPGTPRAPGPSSGPRPTPVTDVAVLCVCDLSPAQCDINCCCDPDCSSVDFSVFSACSVPVVTGDSQFCSQKAVIYSLNFTANPPQRVFELVDQINPSIFCIHITNYKPALSFINPEVPDENNFDTLMKTSDGFTLNAESYVSFTTKLDIPTAAKYEYGVPLQTSDSFLRFPSSLTSSLCTDNNPAAFLVNQAVKCTRKINLEQCEEIEALSMAFYSSPEILRVPDSRKKVPITVQSIVIQSLNKTLTRREDTDVLQPTLVNAGHFSLCVNVVLEVKYSLTYTDAGEVTKADLSFVLGTVSSVVVPLQQKFEIHFLQENTQPVPLSGNPGYVVGLPLAAGFQPHKGSGIIQTTNRYGQLTILHSTTEQDCLALEGVRTPVLFGYTMQSGCKLRLTGALPCQLVAQKVKSLLWGQGFPDYVAPFGNSQAQDMLDWVPIHFITQSFNRKDSCQLPGALVIEVKWTKYGSLLNPQAKIVNVTANLISSSFPEANSGNERTILISTAVTFVDVSAPAEAGFRAPPAINARLPFNFFFPFV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | N-linked_Glycosylation | AVTTEGLNSTEAALA CCCCCCCCCHHHHHH | 58.71 | UniProtKB CARBOHYD | |
| 201 (in isoform 6) | Phosphorylation | - | 4.78 | 19276368 | |
| 206 | Ubiquitination | LDIPTAAKYEYGVPL CCCCCCCCCCCCCCC | 35.83 | - | |
| 285 | Phosphorylation | SRKKVPITVQSIVIQ CCCCCCEEHHHHHHH | 13.36 | - | |
| 288 | Phosphorylation | KVPITVQSIVIQSLN CCCEEHHHHHHHHHH | 17.94 | - | |
| 293 | Phosphorylation | VQSIVIQSLNKTLTR HHHHHHHHHHHCCCC | 23.84 | - | |
| 295 | N-linked_Glycosylation | SIVIQSLNKTLTRRE HHHHHHHHHCCCCCC | 40.28 | UniProtKB CARBOHYD | |
| 396 (in isoform 5) | Phosphorylation | - | 62.55 | - | |
| 505 (in isoform 2) | Phosphorylation | - | 39.88 | - | |
| 528 | N-linked_Glycosylation | NPQAKIVNVTANLIS CCCCEEEEEHHHHHH | 28.97 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TECT1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TECT1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TECT1_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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