CNPY2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNPY2_HUMAN
• UniProt AC: Q9Y2B0
• Protein Name: Protein canopy homolog 2
• Gene Name: CNPY2
• Organism: Homo sapiens (Human).
• Sequence Length: 182
• Subcellular Localization: Endoplasmic reticulum .
• Protein Description: Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation..
• Protein Sequence: MKGWGWLALLLGALLGTAWARRSQDLHCGACRALVDELEWEIAQVDPKKTIQMGSFRINPDGSQSVVEVPYARSEAHLTELLEEICDRMKEYGEQIDPSTHRKNYVRVVGRNGESSELDLQGIRIDSDISGTLKFACESIVEEYEDELIEFFSREADNVKDKLCSKRTDLCDHALHISHDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	GTAWARRSQDLHCGA HHHHHHHCCCCCCHH	23.61	-
48	Ubiquitination	EIAQVDPKKTIQMGS EEEECCCCCCEEEEE	59.07	22817900
48 (in isoform 2)	Ubiquitination	-	59.07	21906983
48 (in isoform 1)	Ubiquitination	-	59.07	21906983
48	Acetylation	EIAQVDPKKTIQMGS EEEECCCCCCEEEEE	59.07	7493417
49	Ubiquitination	IAQVDPKKTIQMGSF EEECCCCCCEEEEEE	57.14	22817900
49	Acetylation	IAQVDPKKTIQMGSF EEECCCCCCEEEEEE	57.14	130663
50	Phosphorylation	AQVDPKKTIQMGSFR EECCCCCCEEEEEEE	23.67	21406692
55	Phosphorylation	KKTIQMGSFRINPDG CCCEEEEEEEECCCC	13.15	23663014
63	Phosphorylation	FRINPDGSQSVVEVP EEECCCCCCEEEECC	27.02	23663014
65	Phosphorylation	INPDGSQSVVEVPYA ECCCCCCEEEECCCC	29.81	23663014
71	Phosphorylation	QSVVEVPYARSEAHL CEEEECCCCCCHHHH	21.59	23663014
86	Glutathionylation	TELLEEICDRMKEYG HHHHHHHHHHHHHHH	2.84	22555962
90	2-Hydroxyisobutyrylation	EEICDRMKEYGEQID HHHHHHHHHHHHHCC	48.99	-
90	Ubiquitination	EEICDRMKEYGEQID HHHHHHHHHHHHHCC	48.99	24816145
92	Phosphorylation	ICDRMKEYGEQIDPS HHHHHHHHHHHCCCC	22.05	20068231
99	Phosphorylation	YGEQIDPSTHRKNYV HHHHCCCCCCCCCEE	32.85	25159151
100	Phosphorylation	GEQIDPSTHRKNYVR HHHCCCCCCCCCEEE	30.96	20068231
105	Phosphorylation	PSTHRKNYVRVVGRN CCCCCCCEEEEECCC	7.83	24719451
115	Phosphorylation	VVGRNGESSELDLQG EECCCCCCCCEECCC	30.43	19664994
116	Phosphorylation	VGRNGESSELDLQGI ECCCCCCCCEECCCE	37.57	29255136
127	Phosphorylation	LQGIRIDSDISGTLK CCCEEECCCCCHHHH	34.18	21815630
130	Phosphorylation	IRIDSDISGTLKFAC EEECCCCCHHHHHHH	30.62	21712546
137	Glutathionylation	SGTLKFACESIVEEY CHHHHHHHHHHHHHH	4.79	22555962
160	Succinylation	SREADNVKDKLCSKR HHCCCCHHHHHHCCC	56.23	23954790
162	Ubiquitination	EADNVKDKLCSKRTD CCCCHHHHHHCCCHH	45.75	24816145
171	Glutathionylation	CSKRTDLCDHALHIS HCCCHHHCCHHHHCC	3.92	22555962
178	Phosphorylation	CDHALHISHDEL--- CCHHHHCCCCCC---	17.71	27050516

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNPY2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNPY2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNPY2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MAP1S_HUMAN	MAP1S	physical	26344197
KIF22_HUMAN	KIF22	physical	28514442
DLG3_HUMAN	DLG3	physical	28514442
VWA1_HUMAN	VWA1	physical	28514442
CTC1_HUMAN	CTC1	physical	28514442
PDIA5_HUMAN	PDIA5	physical	28514442
FBXL4_HUMAN	FBXL4	physical	28514442
CO2A1_HUMAN	COL2A1	physical	28514442
STN1_HUMAN	OBFC1	physical	28514442
GNB1L_HUMAN	GNB1L	physical	28514442
WIPI3_HUMAN	WDR45B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.