FBXL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBXL4_HUMAN
• UniProt AC: Q9UKA2
• Protein Name: F-box/LRR-repeat protein 4
• Gene Name: FBXL4
• Organism: Homo sapiens (Human).
• Sequence Length: 621
• Subcellular Localization: Cytoplasm. Nucleus. Mitochondrion.
• Protein Sequence: MSPVFPMLTVLTMFYYICLRRRARTATRGEMMNTHRAIESNSQTSPLNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSASLPFKRTPPNFQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPNPPAEVRWEILWSERPTKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLEYYTELDAVVLHGVKDKPVLSLKTSLIDMNDIEDDAYAEKDGCGMDSLNKKFSSAVLGEGPNNGYFDKLPYELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNASFPKVFIKKSFTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPVFPMLT ------CCCCHHHHH	29.76	27174698
9	Phosphorylation	SPVFPMLTVLTMFYY CCCHHHHHHHHHHHH	13.76	27174698
12	Phosphorylation	FPMLTVLTMFYYICL HHHHHHHHHHHHHHH	10.82	27174698
15	Phosphorylation	LTVLTMFYYICLRRR HHHHHHHHHHHHHHH	4.90	23401153
16	Phosphorylation	TVLTMFYYICLRRRA HHHHHHHHHHHHHHH	3.63	27174698
28	Asymmetric dimethylarginine	RRARTATRGEMMNTH HHHCCCCHHCHHHHH	36.29	-
28	Methylation	RRARTATRGEMMNTH HHHCCCCHHCHHHHH	36.29	-
34	O-linked_Glycosylation	TRGEMMNTHRAIESN CHHCHHHHHHHHHCC	8.54	30379171
40	Phosphorylation	NTHRAIESNSQTSPL HHHHHHHCCCCCCCC	35.35	26471730
42	Phosphorylation	HRAIESNSQTSPLNA HHHHHCCCCCCCCCH	44.08	26471730
44	Phosphorylation	AIESNSQTSPLNAEV HHHCCCCCCCCCHHH	31.94	28555341
45	Phosphorylation	IESNSQTSPLNAEVV HHCCCCCCCCCHHHH	21.54	21815630
115	Ubiquitination	PSASLPFKRTPPNFQ CCCCCCCCCCCCCCC	54.12	21890473
115	Ubiquitination	PSASLPFKRTPPNFQ CCCCCCCCCCCCCCC	54.12	21890473
182	Ubiquitination	LWSERPTKVNASQAR ECCCCCCCCCHHHHH	35.85	-
202	Phosphorylation	IKQINFPTNLIRLEV HHHCCCCCCEEEEEE	38.22	-
235	Phosphorylation	VKDKPVLSLKTSLID CCCCCEEEEEEEEEC	28.22	24719451
238	Phosphorylation	KPVLSLKTSLIDMND CCEEEEEEEEECHHH	33.77	28857561
239	Phosphorylation	PVLSLKTSLIDMNDI CEEEEEEEEECHHHC	23.03	26657352
267	Phosphorylation	DSLNKKFSSAVLGEG HHHCHHHCHHHCCCC	26.68	27251275
268	Phosphorylation	SLNKKFSSAVLGEGP HHCHHHCHHHCCCCC	26.06	30108239
279	Phosphorylation	GEGPNNGYFDKLPYE CCCCCCCCCCCCHHH	15.66	23312004
344	S-palmitoylation	LEFLQSRCTLVQWLN HHHHHHHCCEEEECC	4.12	29575903
460	Phosphorylation	LQHLSLGSCVMIEDY CCCCCCCCCEEECCH	14.61	-
467	Phosphorylation	SCVMIEDYDVIASMI CCEEECCHHHHHHHH	10.18	-
472	Phosphorylation	EDYDVIASMIGAKCK CCHHHHHHHHCHHCC	10.37	-
537	Ubiquitination	HQLPNLQKLFLTANR HHCCCHHHHHHHCCC	44.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBXL4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBXL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBXL4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM4A_HUMAN	KDM4A	physical	21757720
ERLEC_HUMAN	ERLEC1	physical	24035498
CLGN_HUMAN	CLGN	physical	24035498
ATG9B_HUMAN	ATG9B	physical	28514442
PLCD1_HUMAN	PLCD1	physical	28514442
CRBG1_HUMAN	AIM1	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
LYG2_HUMAN	LYG2	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
CACP_HUMAN	CRAT	physical	28514442
S10A3_HUMAN	S100A3	physical	28514442
PADI3_HUMAN	PADI3	physical	28514442
FA26D_HUMAN	FAM26D	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
TTC9C_HUMAN	TTC9C	physical	28514442
NEUR2_HUMAN	NEU2	physical	28514442
PPAP_HUMAN	ACPP	physical	28514442
CALL3_HUMAN	CALML3	physical	28514442
TRI29_HUMAN	TRIM29	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442
SUN2_HUMAN	SUN2	physical	28514442
MBOA5_HUMAN	LPCAT3	physical	28514442
DNSL2_HUMAN	DNASE1L2	physical	28514442
EPCR_HUMAN	PROCR	physical	28514442
PKP1_HUMAN	PKP1	physical	28514442
PKP3_HUMAN	PKP3	physical	28514442
LEG3_HUMAN	LGALS3	physical	28514442
SPB5_HUMAN	SERPINB5	physical	28514442
TGM3_HUMAN	TGM3	physical	28514442
GPNMB_HUMAN	GPNMB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615471: Mitochondrial DNA depletion syndrome 13 (MTDPS13)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.