PADI3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PADI3_HUMAN
• UniProt AC: Q9ULW8
• Protein Name: Protein-arginine deiminase type-3
• Gene Name: PADI3
• Organism: Homo sapiens (Human).
• Sequence Length: 664
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the deimination of arginine residues of proteins..
• Protein Sequence: MSLQRIVRVSLEHPTSAVCVAGVETLVDIYGSVPEGTEMFEVYGTPGVDIYISPNMERGRERADTRRWRFDATLEIIVVMNSPSNDLNDSHVQISYHSSHEPLPLAYAVLYLTCVDISLDCDLNCEGRQDRNFVDKRQWVWGPSGYGGILLVNCDRDDPSCDVQDNCDQHVHCLQDLEDMSVMVLRTQGPAALFDDHKLVLHTSSYDAKRAQVFHICGPEDVCEAYRHVLGQDKVSYEVPRLHGDEERFFVEGLSFPDAGFTGLISFHVTLLDDSNEDFSASPIFTDTVVFRVAPWIMTPSTLPPLEVYVCRVRNNTCFVDAVAELARKAGCKLTICPQAENRNDRWIQDEMELGYVQAPHKTLPVVFDSPRNGELQDFPYKRILGPDFGYVTREPRDRSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSSGRRVTQVVRDFLHAQKVQPPVELFVDWLAVGHVDEFLSFVPAPDGKGFRMLLASPGACFKLFQEKQKCGHGRALLFQGVVDDEQVKTISINQVLSNKDLINYNKFVQSCIDWNREVLKRELGLAECDIIDIPQLFKTERKKATAFFPDLVNMLVLGKHLGIPKPFGPIINGCCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVCRKPFSFKWWNMVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
209	Ubiquitination	HTSSYDAKRAQVFHI ECCCCCHHHCEEEEE	45.42	29967540
236	Phosphorylation	VLGQDKVSYEVPRLH HHCCCCCEEECCCCC	22.71	-
237	Phosphorylation	LGQDKVSYEVPRLHG HCCCCCEEECCCCCC	24.75	-
363	Phosphorylation	YVQAPHKTLPVVFDS CCCCCCCEECEEEEC	33.01	-
370	Phosphorylation	TLPVVFDSPRNGELQ EECEEEECCCCCCCC	17.81	24719451
505	Acetylation	KLFQEKQKCGHGRAL HHHHHHHCCCCCEEE	53.93	7695583
525	Phosphorylation	VDDEQVKTISINQVL CCHHHCEEEEHHHHH	22.54	29978859
527	Phosphorylation	DEQVKTISINQVLSN HHHCEEEEHHHHHCC	22.25	29978859
533	Phosphorylation	ISINQVLSNKDLINY EEHHHHHCCCCCCCH	42.87	29978859
629	Phosphorylation	EPLGLHCTFIDDFTP HHHCCEEEEECCCCC	16.93	22210691
635	Phosphorylation	CTFIDDFTPYHMLHG EEEECCCCCHHHCCC	29.90	22210691
648	Phosphorylation	HGEVHCGTNVCRKPF CCEEECCCCCCCCCC	29.85	22210691
656	Phosphorylation	NVCRKPFSFKWWNMV CCCCCCCCCCCCCCC	34.15	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PADI3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PADI3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PADI3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PADI3_HUMAN	PADI3	physical	25416956
PADI4_HUMAN	PADI4	physical	28514442
PADI1_HUMAN	PADI1	physical	28514442
NFKB1_HUMAN	NFKB1	physical	28514442
NFKB2_HUMAN	NFKB2	physical	28514442
PML_HUMAN	PML	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.