PADI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PADI1_HUMAN
• UniProt AC: Q9ULC6
• Protein Name: Protein-arginine deiminase type-1
• Gene Name: PADI1
• Organism: Homo sapiens (Human).
• Sequence Length: 663
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the deimination of arginine residues of proteins..
• Protein Sequence: MAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSGSSGVEVFMVYNRTRVKEPIGKARWPLDTDADMVVSVGTASKELKDFKVRVSYFGEQEDQALGRSVLYLTGVDISLEVDTGRTGKVKRSQGDKKTWRWGPEGYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDMSPMLLSCNGPDKLFDSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVERQPGEQEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPWIMTPNTQPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVENRNDRWIQDEMEFGYIEAPHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYVTREIPLPGPSSLDSFGNLDVSPPVTVGGTEYPLGRILIGSSFPKSGGRQMARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFVPTSDQKGFRLLLASPSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDNLHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGKYLGIPKPYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNVRRKPFPFKWWNMVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	DVPKGANSFRVSGSS CCCCCCCCEEEECCC	17.56	-
45	Phosphorylation	NSFRVSGSSGVEVFM CCEEEECCCCEEEEE	19.20	21712546
57	Phosphorylation	VFMVYNRTRVKEPIG EEEEEECCCCCCCCC	35.86	21712546
72	Phosphorylation	KARWPLDTDADMVVS CCCCCCCCCCCEEEE	40.55	-
132	Phosphorylation	RTGKVKRSQGDKKTW CCCCEECCCCCCCCE	32.56	20393185
175	Ubiquitination	HSWLMSLADLQDMSP HHHHHHHHHHHHCCC	14.25	16196087
196	Phosphorylation	GPDKLFDSHKLVLNV CCCCCCCCCEEEEEC	18.39	-
206	Phosphorylation	LVLNVPFSDSKRVRV EEEECCCCCCCCEEE	34.60	-
208	Phosphorylation	LNVPFSDSKRVRVFC EECCCCCCCCEEEEE	22.59	-
226	Acetylation	GNSLSDYKQVLGPQC CCCHHHHHHHHCHHC	38.63	71333
226	Ubiquitination	GNSLSDYKQVLGPQC CCCHHHHHHHHCHHC	38.63	16196087
326	Phosphorylation	EKFLEDMSYLTLKAN HHHHHHCCHHHHCCC	29.34	19835603
327	Phosphorylation	KFLEDMSYLTLKANC HHHHHCCHHHHCCCC	9.32	19835603
329	Phosphorylation	LEDMSYLTLKANCKL HHHCCHHHHCCCCEE	20.27	30619164
372	Phosphorylation	SFPVVFDSPRNRGLK CCCEEECCCCCCCCC	17.81	24719451
439	Phosphorylation	IGSSFPKSGGRQMAR ECCCCCCCCHHHHHH	46.87	18452278
494	Phosphorylation	GFRLLLASPSACLKL CHHHEEECHHHHHHH	21.25	-
595	Phosphorylation	NMVVLGKYLGIPKPY HHHHHHHHCCCCCCC	14.36	-
602	Phosphorylation	YLGIPKPYGPIINGR HCCCCCCCCCCCCCE	41.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PADI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PADI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PADI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAP2_HUMAN	STAP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00155: L-Citrulline