NEUR2_HUMAN - dbPTM
NEUR2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NEUR2_HUMAN
UniProt AC Q9Y3R4
Protein Name Sialidase-2
Gene Name NEU2
Organism Homo sapiens (Human).
Sequence Length 380
Subcellular Localization Cytoplasm.
Protein Description Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides..
Protein Sequence MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationLPVLQKESVFQSGAH
CCCCCHHHHHCCCCH		34.9624043423
15PhosphorylationQKESVFQSGAHAYRI
CHHHHHCCCCHHCCC		26.8724043423
20PhosphorylationFQSGAHAYRIPALLY
HCCCCHHCCCCEEEE		10.1424043423
27PhosphorylationYRIPALLYLPGQQSL
CCCCEEEECCCHHHH		16.2324043423
33PhosphorylationLYLPGQQSLLAFAEQ
EECCCHHHHHHHHHH		19.9124043423
122PhosphorylationLQTRANVTRLCQVTS
HHHHHCHHHEEEEEE		20.1029978859
128PhosphorylationVTRLCQVTSTDHGRT
HHHEEEEEECCCCCC		10.4629978859
129PhosphorylationTRLCQVTSTDHGRTW
HHEEEEEECCCCCCC		32.7429978859
130PhosphorylationRLCQVTSTDHGRTWS
HEEEEEECCCCCCCC		23.7329978859
135PhosphorylationTSTDHGRTWSSPRDL
EECCCCCCCCCCCCC		34.0029978859
137PhosphorylationTDHGRTWSSPRDLTD
CCCCCCCCCCCCCCC		29.8329978859
138PhosphorylationDHGRTWSSPRDLTDA
CCCCCCCCCCCCCCC		18.6029978859
248PhosphorylationRARVQAQSTNDGLDF
HHHHHHHCCCCCCCC		31.99-
249PhosphorylationARVQAQSTNDGLDFQ
HHHHHHCCCCCCCCC		25.83-
314MethylationLGAYLNPRPPAPEAW
CHHHCCCCCCCCCCC		49.084361215
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NEUR2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NEUR2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NEUR2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NT2NL_HUMANNOTCH2NLphysical
25416956
K1671_HUMANKIAA1671physical
26186194
C19L2_HUMANCWF19L2physical
26186194
NOSIP_HUMANNOSIPphysical
26186194
ZWINT_HUMANZWINTphysical
26186194
PEX14_HUMANPEX14physical
26186194
PEX5_HUMANPEX5physical
26186194
NOTC3_HUMANNOTCH3physical
26186194
KEAP1_HUMANKEAP1physical
26186194
TFAP4_HUMANTFAP4physical
26186194
ALKB3_HUMANALKBH3physical
26186194
PEX5_HUMANPEX5physical
28514442
C19L2_HUMANCWF19L2physical
28514442
TFAP4_HUMANTFAP4physical
28514442
ALKB3_HUMANALKBH3physical
28514442
K1671_HUMANKIAA1671physical
28514442
ZWINT_HUMANZWINTphysical
28514442
PEX14_HUMANPEX14physical
28514442
NOTC3_HUMANNOTCH3physical
28514442
KEAP1_HUMANKEAP1physical
28514442
NOSIP_HUMANNOSIPphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00198Oseltamivir
DB00558Zanamivir
Regulatory Network of NEUR2_HUMAN

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Related Literatures of Post-Translational Modification

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