| UniProt ID | PEX5_HUMAN | |
|---|---|---|
| UniProt AC | P50542 | |
| Protein Name | Peroxisomal targeting signal 1 receptor | |
| Gene Name | PEX5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 639 | |
| Subcellular Localization |
Cytoplasm. Peroxisome membrane Peripheral membrane protein. Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13). |
|
| Protein Description | Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.. | |
| Protein Sequence | MAMRELVEAECGGANPLMKLAGHFTQDKALRQEGLRPGPWPPGAPASEAASKPLGVASEDELVAEFLQDQNAPLVSRAPQTFKMDDLLAEMQQIEQSNFRQAPQRAPGVADLALSENWAQEFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTATDRWYDEYHPEEDLQHTASDFVAKVDDPKLANSEFLKFVRQIGEGQVSLESGAGSGRAQAEQWAAEFIQQQGTSDAWVDQFTRPVNTSALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDDLTSATYDKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEYDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCINLGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSTLLTMFGLPQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Sulfoxidation | CGGANPLMKLAGHFT HCCCCHHHHHHHCCH | 3.36 | 21406390 | |
| 28 | Ubiquitination | AGHFTQDKALRQEGL HHCCHHHHHHHHCCC | 39.23 | - | |
| 28 | Acetylation | AGHFTQDKALRQEGL HHCCHHHHHHHHCCC | 39.23 | 23749302 | |
| 40 | Ubiquitination | EGLRPGPWPPGAPAS CCCCCCCCCCCCCHH | 20.03 | - | |
| 47 | Phosphorylation | WPPGAPASEAASKPL CCCCCCHHHHHCCCC | 27.06 | 28122231 | |
| 49 | Ubiquitination | PGAPASEAASKPLGV CCCCHHHHHCCCCCC | 17.97 | - | |
| 49 | Acetylation | PGAPASEAASKPLGV CCCCHHHHHCCCCCC | 17.97 | - | |
| 51 | Phosphorylation | APASEAASKPLGVAS CCHHHHHCCCCCCCC | 41.68 | 24719451 | |
| 57 (in isoform 4) | Phosphorylation | - | 12.85 | 25159151 | |
| 58 | Phosphorylation | SKPLGVASEDELVAE CCCCCCCCHHHHHHH | 43.08 | 26074081 | |
| 73 | Ubiquitination | FLQDQNAPLVSRAPQ HHHCCCCCCCCCCCC | 40.62 | - | |
| 76 | Phosphorylation | DQNAPLVSRAPQTFK CCCCCCCCCCCCCCC | 30.33 | 28122231 | |
| 79 | Phosphorylation | APLVSRAPQTFKMDD CCCCCCCCCCCCHHH | 32.41 | - | |
| 98 (in isoform 4) | Ubiquitination | - | 35.50 | - | |
| 104 | Ubiquitination | SNFRQAPQRAPGVAD CCCCCCCHHCCCHHH | 58.12 | - | |
| 115 | Phosphorylation | GVADLALSENWAQEF CHHHHHCCCCHHHHH | 24.23 | 24275569 | |
| 136 | Phosphorylation | VDVTQDYNETDWSQE EEECCCCCCCCCHHH | 54.72 | - | |
| 141 | Phosphorylation | DYNETDWSQEFISEV CCCCCCCHHHHHHHC | 23.73 | - | |
| 149 | Phosphorylation | QEFISEVTDPLSVSP HHHHHHCCCCCCCCH | 28.04 | 24275569 | |
| 153 | Phosphorylation | SEVTDPLSVSPARWA HHCCCCCCCCHHHHH | 26.41 | 26074081 | |
| 155 | Phosphorylation | VTDPLSVSPARWAEE CCCCCCCCHHHHHHH | 14.96 | 26074081 | |
| 162 | Phosphorylation | SPARWAEEYLEQSEE CHHHHHHHHHHHCHH | 47.90 | - | |
| 163 | Phosphorylation | PARWAEEYLEQSEEK HHHHHHHHHHHCHHH | 13.67 | 28796482 | |
| 167 | Phosphorylation | AEEYLEQSEEKLWLG HHHHHHHCHHHCCCC | 38.04 | 21815630 | |
| 170 | Phosphorylation | YLEQSEEKLWLGEPE HHHHCHHHCCCCCCC | 40.69 | - | |
| 174 | Phosphorylation | SEEKLWLGEPEGTAT CHHHCCCCCCCCCCC | 36.51 | - | |
| 176 | Phosphorylation | EKLWLGEPEGTATDR HHCCCCCCCCCCCCC | 43.44 | - | |
| 182 (in isoform 4) | Phosphorylation | - | 36.33 | 27251275 | |
| 185 | Phosphorylation | GTATDRWYDEYHPEE CCCCCCCCHHCCCHH | 10.37 | 29978859 | |
| 188 | Phosphorylation | TDRWYDEYHPEEDLQ CCCCCHHCCCHHHHH | 21.56 | 28796482 | |
| 209 (in isoform 1) | Ubiquitination | - | 68.19 | 21890473 | |
| 209 (in isoform 3) | Ubiquitination | - | 68.19 | 21890473 | |
| 209 | Ubiquitination | VAKVDDPKLANSEFL HHHCCCHHHCCHHHH | 68.19 | 21890473 | |
| 217 (in isoform 1) | Ubiquitination | - | 47.32 | 21890473 | |
| 217 (in isoform 3) | Ubiquitination | - | 47.32 | 21890473 | |
| 217 | Ubiquitination | LANSEFLKFVRQIGE HCCHHHHHHHHHHCC | 47.32 | 21890473 | |
| 224 | Ubiquitination | KFVRQIGEGQVSLES HHHHHHCCCEEEECC | 48.35 | 21890473 | |
| 224 (in isoform 4) | Ubiquitination | - | 48.35 | - | |
| 225 | Ubiquitination | FVRQIGEGQVSLESG HHHHHCCCEEEECCC | 28.16 | - | |
| 228 | Phosphorylation | QIGEGQVSLESGAGS HHCCCEEEECCCCCC | 20.66 | 28555341 | |
| 230 | Ubiquitination | GEGQVSLESGAGSGR CCCEEEECCCCCCCH | 39.35 | - | |
| 231 | Phosphorylation | EGQVSLESGAGSGRA CCEEEECCCCCCCHH | 38.96 | 25072903 | |
| 232 (in isoform 4) | Ubiquitination | - | 25.28 | - | |
| 232 | Ubiquitination | GQVSLESGAGSGRAQ CEEEECCCCCCCHHH | 25.28 | 21890473 | |
| 235 | Phosphorylation | SLESGAGSGRAQAEQ EECCCCCCCHHHHHH | 25.27 | 25072903 | |
| 238 | Ubiquitination | SGAGSGRAQAEQWAA CCCCCCHHHHHHHHH | 19.23 | - | |
| 241 (in isoform 2) | Ubiquitination | - | 34.28 | 21890473 | |
| 243 (in isoform 4) | Phosphorylation | - | 6.74 | 27251275 | |
| 249 | Phosphorylation | QWAAEFIQQQGTSDA HHHHHHHHHHCCCCH | 34.56 | - | |
| 267 | Phosphorylation | QFTRPVNTSALDMEF HHCCCCCCHHHHHHH | 18.66 | 26074081 | |
| 268 | Phosphorylation | FTRPVNTSALDMEFE HCCCCCCHHHHHHHH | 22.94 | 26074081 | |
| 278 | Ubiquitination | DMEFERAKSAIESDV HHHHHHHHHHHHCCH | 46.79 | 21906983 | |
| 278 (in isoform 1) | Ubiquitination | - | 46.79 | 21890473 | |
| 279 | Phosphorylation | MEFERAKSAIESDVD HHHHHHHHHHHCCHH | 33.23 | 7719337 | |
| 279 (in isoform 3) | Phosphorylation | - | 33.23 | 27251275 | |
| 283 | Phosphorylation | RAKSAIESDVDFWDK HHHHHHHCCHHHHHH | 36.50 | 29514088 | |
| 294 (in isoform 4) | Phosphorylation | - | 43.69 | 27251275 | |
| 299 | Ubiquitination | QAELEEMAKRDAEAH HHHHHHHHHHHHHHC | 13.65 | - | |
| 300 | Phosphorylation | AELEEMAKRDAEAHP HHHHHHHHHHHHHCC | 49.88 | - | |
| 304 | Phosphorylation | EMAKRDAEAHPWLSD HHHHHHHHHCCCCCC | 52.37 | - | |
| 310 | Phosphorylation | AEAHPWLSDYDDLTS HHHCCCCCCHHHHHH | 30.20 | 28796482 | |
| 311 | Ubiquitination | EAHPWLSDYDDLTSA HHCCCCCCHHHHHHC | 49.03 | - | |
| 312 | Phosphorylation | AHPWLSDYDDLTSAT HCCCCCCHHHHHHCC | 14.16 | 28796482 | |
| 317 | Phosphorylation | SDYDDLTSATYDKGY CCHHHHHHCCCCCCC | 26.38 | 24275569 | |
| 321 | Ubiquitination | DLTSATYDKGYQFEE HHHHCCCCCCCCCCC | 33.28 | - | |
| 338 | Phosphorylation | PLRDHPQPFEEGLRR CCCCCCCCHHHHHHH | 42.96 | - | |
| 343 | Ubiquitination | PQPFEEGLRRLQEGD CCCHHHHHHHHHHCC | 3.05 | - | |
| 419 (in isoform 2) | Ubiquitination | - | 44.73 | 21890473 | |
| 448 (in isoform 3) | Ubiquitination | - | 37.02 | 21890473 | |
| 456 (in isoform 1) | Ubiquitination | - | 46.74 | 21890473 | |
| 456 | Ubiquitination | GAGLGPSKRILGSLL CCCCCCCHHHHHHHH | 46.74 | 21890473 | |
| 456 | Acetylation | GAGLGPSKRILGSLL CCCCCCCHHHHHHHH | 46.74 | 25953088 | |
| 466 | Phosphorylation | LGSLLSDSLFLEVKE HHHHHCCCHHHHHHH | 20.04 | 24719451 | |
| 471 (in isoform 4) | Ubiquitination | - | 6.76 | - | |
| 471 | Ubiquitination | SDSLFLEVKELFLAA CCCHHHHHHHHHHHH | 6.76 | 21890473 | |
| 477 | Ubiquitination | EVKELFLAAVRLDPT HHHHHHHHHHCCCCC | 9.14 | - | |
| 481 (in isoform 4) | Phosphorylation | - | 8.11 | 24719451 | |
| 538 | Phosphorylation | TLANGNQSEEAVAAY EECCCCCCHHHHHHH | 41.21 | 20068231 | |
| 548 | Ubiquitination | AVAAYRRALELQPGY HHHHHHHHHHCCCCC | 9.08 | - | |
| 629 | Phosphorylation | AADARDLSTLLTMFG CCCHHHHHHHHHHHC | 22.69 | 25262027 | |
| 630 | Phosphorylation | ADARDLSTLLTMFGL CCHHHHHHHHHHHCC | 32.84 | 20068231 | |
| 633 | Phosphorylation | RDLSTLLTMFGLPQ- HHHHHHHHHHCCCC- | 17.36 | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 141 | S | Phosphorylation | Kinase | ATM | Q13315 | PSP |
| - | K | Ubiquitination | E3 ubiquitin ligase | PEX12 | O00623 | PMID:19687296 |
| - | K | Ubiquitination | E3 ubiquitin ligase | PEX10 | O60683 | PMID:22199232 |
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 11 | C | ubiquitylation |
| - |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PEX5_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00205 | Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NAL | |||||
| OMIM Disease | ||||||
| 214110 | Peroxisome biogenesis disorder 2A (PBD2A) | |||||
| 202370 | Peroxisome biogenesis disorder 2B (PBD2B) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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