SPYA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPYA_HUMAN
• UniProt AC: P21549
• Protein Name: Serine--pyruvate aminotransferase
• Gene Name: AGXT
• Organism: Homo sapiens (Human).
• Sequence Length: 392
• Subcellular Localization: Peroxisome . Mitochondrion . Predominantly localized in the peroxisomes. Mitochondrial mistargeting occurs in variant proteins Arg-41, Arg-47, Ile-152, Arg-170 and Thr-244 associated with the disease HP1.
• Protein Sequence: MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQHCPKKKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASHKLLVTP -----CCCCCEEECC	21.61	28258704
9	Phosphorylation	ASHKLLVTPPKALLK CCCCEEECCCHHHCC	33.57	21902226
48	Phosphorylation	GGLQMIGSMSKDMYQ HCCEEECCCCHHHHH	14.68	21406692
50	Phosphorylation	LQMIGSMSKDMYQIM CEEECCCCHHHHHHH	27.48	21406692
81	Phosphorylation	LTLVISGSGHCALEA EEEEECCCCCHHHHH	20.69	69009055
194	Phosphorylation	SLGGTPLYMDRQGID HCCCCCCEECCCCCE	9.73	7103239
205	Phosphorylation	QGIDILYSGSQKALN CCCEEEEECCCCHHC	28.64	25072903
207	Phosphorylation	IDILYSGSQKALNAP CEEEEECCCCHHCCC	23.67	25072903
209	Other	ILYSGSQKALNAPPG EEEECCCCHHCCCCC	57.44	-
209	N6-(pyridoxal phosphate)lysine	ILYSGSQKALNAPPG EEEECCCCHHCCCCC	57.44	-
225	Succinylation	SLISFSDKAKKKMYS CEEECCHHHHHHHHC	61.99	-
225	Acetylation	SLISFSDKAKKKMYS CEEECCHHHHHHHHC	61.99	-
225	Succinylation	SLISFSDKAKKKMYS CEEECCHHHHHHHHC	61.99	-
228	Trimethylation	SFSDKAKKKMYSRKT ECCHHHHHHHHCCCC	47.86	-
228	Methylation	SFSDKAKKKMYSRKT ECCHHHHHHHHCCCC	47.86	23644510
231	Phosphorylation	DKAKKKMYSRKTKPF HHHHHHHHCCCCCCE	17.76	10409595
234	Acetylation	KKKMYSRKTKPFSFY HHHHHCCCCCCEEEE	55.76	-
235	Phosphorylation	KKMYSRKTKPFSFYL HHHHCCCCCCEEEEE	42.72	23898821
239	Phosphorylation	SRKTKPFSFYLDIKW CCCCCCEEEEEEHHH	22.85	23898821
241	Phosphorylation	KTKPFSFYLDIKWLA CCCCEEEEEEHHHHH	11.41	23898821
260	Phosphorylation	CDDQPRMYHHTIPVI CCCCCCCCCCCCCEE	7.54	21253578
271	Phosphorylation	IPVISLYSLRESLAL CCEEEHHCHHHHHHH	26.66	24719451
275	Phosphorylation	SLYSLRESLALIAEQ EHHCHHHHHHHHHHH	16.71	20873877
287	Phosphorylation	AEQGLENSWRQHREA HHHCHHHHHHHHHHH	17.79	20873877
297	Phosphorylation	QHREAAAYLHGRLQA HHHHHHHHHHHHHHH	8.43	21253578
312	Acetylation	LGLQLFVKDPALRLP HCCCEEECCCCCCCC	51.14	-
354	Phosphorylation	IMGGLGPSTGKVLRI EECCCCCCCCCEEEE	48.25	24275569
389	Acetylation	AALQHCPKKKL---- HHHHHCCCCCC----	68.86	24885217

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPYA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPYA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPYA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPYA_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 259900: Hyperoxaluria primary 1 (HP1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00145: Glycine
• DB00160: L-Alanine
• DB00133: L-Serine