PEX13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEX13_HUMAN
• UniProt AC: Q92968
• Protein Name: Peroxisomal membrane protein PEX13
• Gene Name: PEX13
• Organism: Homo sapiens (Human).
• Sequence Length: 403
• Subcellular Localization: Peroxisome membrane ; Single-pass membrane protein .
• Protein Description: Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins..
• Protein Sequence: MASQPPPPPKPWETRRIPGAGPGPGPGPTFQSADLGPTLMTRPGQPALTRVPPPILPRPSQQTGSSSVNTFRPAYSSFSSGYGAYGNSFYGGYSPYSYGYNGLGYNRLRVDDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHFTKVFSAFALVRTIRYLYRRLQRMLGLRRGSENEDLWAESEGTVACLGAEDRAATSAKSWPIFLFFAVILGGPYLIWKLLSTHSDEVTDSINWASGEDDHVVARAEYDFAAVSEEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGKRKGRKTVESSKVSKQQQSFTNPTLTKGATVADSLDEQEAAFESVFVETNKVPVAPDSIGKDGEKQDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Phosphorylation	YSSFSSGYGAYGNSF CHHHCCCCCCCCCCC	10.67	-
98	Phosphorylation	GGYSPYSYGYNGLGY CCCCCCCCCCCCCCC	20.13	-
100	Phosphorylation	YSPYSYGYNGLGYNR CCCCCCCCCCCCCCC	9.60	-
172	Ubiquitination	ANHFSRLKIHFTKVF HHHHHHCCCHHHHHH	32.78	33845483
205	Phosphorylation	MLGLRRGSENEDLWA HHCCCCCCCCCCCCC	35.12	25849741
304	Ubiquitination	DMLNLALKEQQPKVR HHHHHHHHHHCCCCC	48.12	22817900
309	Ubiquitination	ALKEQQPKVRGWLLA HHHHHCCCCCCEEEE	39.98	22817900
338	Ubiquitination	VKILGKRKGRKTVES HHHHCCCCCCCCCHH	67.56	-
341	Ubiquitination	LGKRKGRKTVESSKV HCCCCCCCCCHHHCC	66.64	-
347	Ubiquitination	RKTVESSKVSKQQQS CCCCHHHCCCHHHHC	60.86	33845483
350	Ubiquitination	VESSKVSKQQQSFTN CHHHCCCHHHHCCCC	55.93	33845483
354	Phosphorylation	KVSKQQQSFTNPTLT CCCHHHHCCCCCCCC	29.69	28555341
365	Phosphorylation	PTLTKGATVADSLDE CCCCCCCCCCCCCCH	25.54	-
393	Phosphorylation	KVPVAPDSIGKDGEK CCCCCCCCCCCCCCC	31.98	21815630
396	Ubiquitination	VAPDSIGKDGEKQDL CCCCCCCCCCCCCCC	61.97	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEX13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEX13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEX13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEX5_HUMAN	PEX5	physical	8858165
PEX5_HUMAN	PEX5	physical	11865044
PEX7_HUMAN	PEX7	physical	11865044
PEX14_HUMAN	PEX14	physical	11865044
PEX13_HUMAN	PEX13	physical	12096124
PEX19_HUMAN	PEX19	physical	12096124
SPR2A_HUMAN	SPRR2A	physical	18155796

Drug and Disease Associations

• Kegg Disease
• H00205: Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NAL
• OMIM Disease
• 614883: Peroxisome biogenesis disorder complementation group 13 (PBD-CG13)
• 614883: Peroxisome biogenesis disorder 11A (PBD11A)
• 614885: Peroxisome biogenesis disorder 11B (PBD11B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.