PEX7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEX7_HUMAN
• UniProt AC: O00628
• Protein Name: Peroxisomal targeting signal 2 receptor
• Gene Name: PEX7
• Organism: Homo sapiens (Human).
• Sequence Length: 323
• Subcellular Localization: Peroxisome. Cytoplasm.
• Protein Description: Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import..
• Protein Sequence: MSAVCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPACLTIPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	Acetylation	GSWDQTVKLWDPTVG EECCCCEEEECCCCC	47.44	7465771
186	Ubiquitination	TLRIWDVKAAGVRIV EEEEEEEEECCEEEE	30.00	21890473
186	Ubiquitination	TLRIWDVKAAGVRIV EEEEEEEEECCEEEE	30.00	21890473
256	Phosphorylation	KFSPFHASVLASCSY ECCCCCHHHHHHCCC	14.75	-
260	Phosphorylation	FHASVLASCSYDFTV CCHHHHHHCCCEEEE	10.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEX7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEX7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEX7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAHX_HUMAN	PHYH	physical	9326939
PEX5_HUMAN	PEX5	physical	11546814
THIL_HUMAN	ACAT1	physical	22057399
KDM1A_HUMAN	KDM1A	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
TCPH_HUMAN	CCT7	physical	26186194
TCPD_HUMAN	CCT4	physical	26186194
TCPG_HUMAN	CCT3	physical	26186194
TCPW_HUMAN	CCT6B	physical	26186194
TCPZ_HUMAN	CCT6A	physical	26186194
TCPB_HUMAN	CCT2	physical	26186194
PDCL3_HUMAN	PDCL3	physical	26186194
TCPA_HUMAN	TCP1	physical	26186194
TCPE_HUMAN	CCT5	physical	26186194
PHLP_HUMAN	PDCL	physical	26186194
TXND9_HUMAN	TXNDC9	physical	26186194
PFD3_HUMAN	VBP1	physical	26186194
PEX13_HUMAN	PEX13	physical	26186194
TLE3_HUMAN	TLE3	physical	26186194
CF226_HUMAN	C6orf226	physical	26186194
PEX5R_HUMAN	PEX5L	physical	25538232
PEX13_HUMAN	PEX13	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
PDCL3_HUMAN	PDCL3	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442
TCPQ_HUMAN	CCT8	physical	28514442
PHLP_HUMAN	PDCL	physical	28514442
PFD3_HUMAN	VBP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614879: Peroxisome biogenesis disorder complementation group 11 (PBD-CG11)
• 215100: Rhizomelic chondrodysplasia punctata 1 (RCDP1)
• 614879: Peroxisome biogenesis disorder 9B (PBD9B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.