PEX5R_HUMAN - dbPTM
PEX5R_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PEX5R_HUMAN
UniProt AC Q8IYB4
Protein Name PEX5-related protein
Gene Name PEX5L
Organism Homo sapiens (Human).
Sequence Length 626
Subcellular Localization Cytoplasm. Membrane
Peripheral membrane protein. Some fraction is membrane associated via its interaction with RAB8B..
Protein Description Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence..
Protein Sequence MYQGHMQKSKEQGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPLLTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQTKAKKSEPSSKTSSLKKKADGSDLISTDAEQRGQPLRVPETSSLDLDIQTQLEKWDDVKFHGDRNTKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVAPTQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQEAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAANLGDLDVLLRAFNLDP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationQKSKEQGYGKLSSDE
CCCCCCCCCCCCCCC		15.6929759185
18PhosphorylationEQGYGKLSSDEDLEI
CCCCCCCCCCCCCEE		38.9528348404
19PhosphorylationQGYGKLSSDEDLEII
CCCCCCCCCCCCEEE		56.2928348404
40AcetylationKGSRAADKAVAMVMK
CCCHHHHHHHHHHHH		39.7825953088
74PhosphorylationLVNEQQESRPLLSPS
HHHHCHHHCCCCCCC		34.5626074081
78UbiquitinationQQESRPLLSPSIDDF
CHHHCCCCCCCHHHH		8.6230230243
79PhosphorylationQESRPLLSPSIDDFL
HHHCCCCCCCHHHHH		25.0426074081
81PhosphorylationSRPLLSPSIDDFLCE
HCCCCCCCHHHHHHC		34.9626074081
89PhosphorylationIDDFLCETKSEAIAR
HHHHHHCCCCHHHCC		38.5828122231
99PhosphorylationEAIARPVTSNTAVLT
HHHCCCCCCCCEEEE		20.95-
106PhosphorylationTSNTAVLTTGLDLLD
CCCCEEEECCCCHHC		16.54-
115PhosphorylationGLDLLDLSEPVSQTQ
CCCHHCCCCCCCCHH		39.25-
123PhosphorylationEPVSQTQTKAKKSEP
CCCCCHHCHHHCCCC		36.04-
143UbiquitinationSLKKKADGSDLISTD
HCCHHCCCCCCCCCC		28.1129967540
162UbiquitinationGQPLRVPETSSLDLD
CCCCCCCCCCCCCCC		59.4730230243
163PhosphorylationQPLRVPETSSLDLDI
CCCCCCCCCCCCCCH		19.9728348404
164PhosphorylationPLRVPETSSLDLDIQ
CCCCCCCCCCCCCHH		27.5228348404
165PhosphorylationLRVPETSSLDLDIQT
CCCCCCCCCCCCHHH		33.0728348404
181UbiquitinationLEKWDDVKFHGDRNT
HHHCCCCEECCCCCC		38.3430230243
194UbiquitinationNTKGHPMAERKSSSS
CCCCCCCCCCCCCCC		20.2130230243
198PhosphorylationHPMAERKSSSSRTGS
CCCCCCCCCCCCCCC		41.4929759185
199PhosphorylationPMAERKSSSSRTGSK
CCCCCCCCCCCCCCC		35.0529759185
203PhosphorylationRKSSSSRTGSKELLW
CCCCCCCCCCCHHHC		47.9928111955
203UbiquitinationRKSSSSRTGSKELLW
CCCCCCCCCCCHHHC		47.9930230243
205PhosphorylationSSSSRTGSKELLWSS
CCCCCCCCCHHHCCC		23.5028111955
211UbiquitinationGSKELLWSSEHRSQP
CCCHHHCCCCCCCCC		26.3130230243
216PhosphorylationLWSSEHRSQPELSGG
HCCCCCCCCCCCCCC		52.5828348404
227UbiquitinationLSGGKSALNSESASE
CCCCHHCCCCCCHHH		10.5330230243
229UbiquitinationGGKSALNSESASELE
CCHHCCCCCCHHHCE		33.5030230243
235UbiquitinationNSESASELELVAPTQ
CCCCHHHCEECCCCH		5.9730230243
246PhosphorylationAPTQARLTKEHRWGS
CCCHHCCCHHHHHHH		28.9128634120
246UbiquitinationAPTQARLTKEHRWGS
CCCHHCCCHHHHHHH		28.9130230243
253PhosphorylationTKEHRWGSALLSRNH
CHHHHHHHHHHHCCC		14.5825307156
254UbiquitinationKEHRWGSALLSRNHS
HHHHHHHHHHHCCCC		14.4830230243
257PhosphorylationRWGSALLSRNHSLEE
HHHHHHHHCCCCHHH		31.7028111955
259UbiquitinationGSALLSRNHSLEEEF
HHHHHHCCCCHHHHH		26.2330230243
260UbiquitinationSALLSRNHSLEEEFE
HHHHHCCCCHHHHHH		32.4230230243
261PhosphorylationALLSRNHSLEEEFER
HHHHCCCCHHHHHHH		40.8124670416
268UbiquitinationSLEEEFERAKAAVES
CHHHHHHHHHHHHHC		46.8630230243
270UbiquitinationEEEFERAKAAVESDT
HHHHHHHHHHHHCCH		43.0030230243
275PhosphorylationRAKAAVESDTEFWDK
HHHHHHHCCHHHHHH		43.1428348404
276UbiquitinationAKAAVESDTEFWDKM
HHHHHHCCHHHHHHH		36.4329967540
277PhosphorylationKAAVESDTEFWDKMQ
HHHHHCCHHHHHHHH		42.2228348404
290UbiquitinationMQAEWEEMARRNWIS
HHHHHHHHHHHHCCC		2.0830230243
292UbiquitinationAEWEEMARRNWISEN
HHHHHHHHHHCCCCC		31.0230230243
294UbiquitinationWEEMARRNWISENQE
HHHHHHHHCCCCCHH		34.5730230243
300UbiquitinationRNWISENQEAQNQVT
HHCCCCCHHHHHCCE		43.2729967540
311UbiquitinationNQVTISASEKGYYFH
HCCEEEHHHCCEEEE		32.8129967540
325UbiquitinationHTENPFKDWPGAFEE
ECCCCCCCCCCHHHH		58.1230230243
333UbiquitinationWPGAFEEGLKRLKEG
CCCHHHHHHHHHHCC		29.3329967540
335UbiquitinationGAFEEGLKRLKEGDL
CHHHHHHHHHHCCCC		67.5529967540
338UbiquitinationEEGLKRLKEGDLPVT
HHHHHHHHCCCCCEE		64.7830230243
357UbiquitinationEAAILQDPGDAEAWQ
EEHHHCCCCCHHHHH		29.6030230243
370UbiquitinationWQFLGITQAENENEQ
HHHHCCEECCCHHHH		44.7730230243
379UbiquitinationENENEQAAIVALQRC
CCHHHHHHHHHHHHH		9.1130230243
387UbiquitinationIVALQRCLELQPNNL
HHHHHHHHHHCCCCH		8.8430230243
403UbiquitinationALMALAVSYTNTGHQ
HHHHHHHHHCCCCCC		22.1930230243
405UbiquitinationMALAVSYTNTGHQQD
HHHHHHHCCCCCCHH		20.8530230243
411UbiquitinationYTNTGHQQDACDALK
HCCCCCCHHHHHHHH		34.3030230243
422UbiquitinationDALKNWIKQNPKYKY
HHHHHHHHHCCCCCE		35.3230230243
435UbiquitinationKYLVKSKKGSPGLTR
CEEECCCCCCCCCCC		72.2530230243
436UbiquitinationYLVKSKKGSPGLTRR
EEECCCCCCCCCCCC		42.6930230243
437PhosphorylationLVKSKKGSPGLTRRM
EECCCCCCCCCCCCC		25.3630576142
444UbiquitinationSPGLTRRMSKSPVDS
CCCCCCCCCCCCCCH		5.5030230243
445PhosphorylationPGLTRRMSKSPVDSS
CCCCCCCCCCCCCHH		28.3328111955
446UbiquitinationGLTRRMSKSPVDSSV
CCCCCCCCCCCCHHH		49.8130230243
447PhosphorylationLTRRMSKSPVDSSVL
CCCCCCCCCCCHHHH		23.8929255136
451PhosphorylationMSKSPVDSSVLEGVK
CCCCCCCHHHHHHHH		23.6828111955
452PhosphorylationSKSPVDSSVLEGVKE
CCCCCCHHHHHHHHH		26.6828111955
466UbiquitinationELYLEAAHQNGDMID
HHHHHHHHHCCCCCC		28.7830230243
468UbiquitinationYLEAAHQNGDMIDPD
HHHHHHHCCCCCCCC		38.2730230243
470UbiquitinationEAAHQNGDMIDPDLQ
HHHHHCCCCCCCCHH		38.1130230243
501UbiquitinationIDAFNAALTVRPEDY
HHHHHHHHEECHHHH		4.1730230243
546PhosphorylationPGFIRSRYNLGISCI
CCCHHHCCCCCCEEE		18.9122210691
570PhosphorylationSNFLTALSLQRKSRN
HHHHHHHHHHHHCCC		21.7124719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PEX5R_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PEX5R_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PEX5R_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PEX5R_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PEX5R_HUMAN

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Related Literatures of Post-Translational Modification

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