| UniProt ID | NOS2_HUMAN | |
|---|---|---|
| UniProt AC | P35228 | |
| Protein Name | Nitric oxide synthase, inducible | |
| Gene Name | NOS2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1153 | |
| Subcellular Localization | ||
| Protein Description | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. [PubMed: 7531687] | |
| Protein Sequence | MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDRVAVQPSSLEMSAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | S-palmitoylation | -----MACPWKFLFK -----CCCCCCEEEE | 6.68 | 16569659 | |
| 35 | Phosphorylation | VEKAPCATSSPVTQD CCCCCCCCCCCCCHH | 36.13 | 23312004 | |
| 36 | Phosphorylation | EKAPCATSSPVTQDD CCCCCCCCCCCCHHH | 17.70 | 26657352 | |
| 37 | Phosphorylation | KAPCATSSPVTQDDL CCCCCCCCCCCHHHH | 21.02 | 23312004 | |
| 40 | Phosphorylation | CATSSPVTQDDLQYH CCCCCCCCHHHHHHH | 29.66 | 23312004 | |
| 46 | Phosphorylation | VTQDDLQYHNLSKQQ CCHHHHHHHCCCCCC | 10.44 | 28442448 | |
| 50 | Phosphorylation | DLQYHNLSKQQNESP HHHHHCCCCCCCCCC | 33.46 | 23312004 | |
| 56 | Phosphorylation | LSKQQNESPQPLVET CCCCCCCCCCCCHHC | 36.06 | 26657352 | |
| 63 | Phosphorylation | SPQPLVETGKKSPES CCCCCHHCCCCCHHH | 46.99 | 26657352 | |
| 67 | Phosphorylation | LVETGKKSPESLVKL CHHCCCCCHHHHEEC | 37.07 | 26657352 | |
| 70 | Phosphorylation | TGKKSPESLVKLDAT CCCCCHHHHEECCCC | 41.67 | 23312004 | |
| 77 | Phosphorylation | SLVKLDATPLSSPRH HHEECCCCCCCCCCE | 25.16 | 23312004 | |
| 80 | Phosphorylation | KLDATPLSSPRHVRI ECCCCCCCCCCEEEE | 39.23 | 17081983 | |
| 81 | Phosphorylation | LDATPLSSPRHVRIK CCCCCCCCCCEEEEC | 33.37 | 17081983 | |
| 112 | Phosphorylation | KGILTCRSKSCLGSI CCEEEECCCCHHCCC | 30.94 | 24719451 | |
| 124 | Phosphorylation | GSIMTPKSLTRGPRD CCCCCCCCCCCCCCC | 35.86 | 24719451 | |
| 126 | Phosphorylation | IMTPKSLTRGPRDKP CCCCCCCCCCCCCCC | 40.44 | 22210691 | |
| 151 | Phosphorylation | IEFVNQYYGSFKEAK HHHHHHHHCCCHHHH | 9.13 | 22817900 | |
| 234 | Phosphorylation | ICRHVRYSTNNGNIR HHHHHHHHCCCCCCC | 17.69 | - | |
| 267 | Phosphorylation | WNAQLIRYAGYQMPD EEHHHHHHCCEECCC | 9.44 | - | |
| 270 | Phosphorylation | QLIRYAGYQMPDGSI HHHHHCCEECCCCCC | 8.09 | - | |
| 299 | Nitrated tyrosine | DLGWKPKYGRFDVVP CCCCCCCCCCCCEEE | 23.28 | - | |
| 299 | Nitration | DLGWKPKYGRFDVVP CCCCCCCCCCCCEEE | 23.28 | 12097137 | |
| 336 | Nitrated tyrosine | VAMEHPKYEWFRELE HHCCCCCCHHHHHHC | 23.89 | - | |
| 336 | Nitration | VAMEHPKYEWFRELE HHCCCCCCHHHHHHC | 23.89 | 12097137 | |
| 425 | Phosphorylation | INIAVLHSFQKQNVT EEEEEHHHHHHCCCE | 25.80 | 29391485 | |
| 446 | Phosphorylation | AAESFMKYMQNEYRS HHHHHHHHHHHHHHH | 7.67 | 12097137 | |
| 446 | Nitrated tyrosine | AAESFMKYMQNEYRS HHHHHHHHHHHHHHH | 7.67 | - | |
| 446 | Nitration | AAESFMKYMQNEYRS HHHHHHHHHHHHHHH | 7.67 | 12097137 | |
| 451 | Phosphorylation | MKYMQNEYRSRGGCP HHHHHHHHHHCCCCC | 22.80 | - | |
| 453 | Phosphorylation | YMQNEYRSRGGCPAD HHHHHHHHCCCCCCC | 34.08 | - | |
| 516 | Ubiquitination | KRREIPLKVLVKAVL CCCCCCHHHHHHHHH | 28.33 | - | |
| 575 | Phosphorylation | KVVCMDKYRLSCLEE CEEEEECCHHHHHHH | 16.72 | - | |
| 578 | Phosphorylation | CMDKYRLSCLEEERL EEECCHHHHHHHCCE | 13.99 | - | |
| 604 | Acetylation | DCPGNGEKLKKSLFM CCCCCHHHHHHHHHH | 67.99 | 30589503 | |
| 670 | Methylation | SGQEDAFRSWAVQTF CCCHHHHHHHHHHHH | 32.77 | 115372633 | |
| 670 | Dimethylation | SGQEDAFRSWAVQTF CCCHHHHHHHHHHHH | 32.77 | - | |
| 671 | Phosphorylation | GQEDAFRSWAVQTFK CCHHHHHHHHHHHHH | 16.97 | 29449344 | |
| 676 | Phosphorylation | FRSWAVQTFKAACET HHHHHHHHHHHHHHH | 22.09 | 29449344 | |
| 698 | Nitrated tyrosine | HIQIPKLYTSNVTWD EEECCEEEECCCCCC | 17.78 | - | |
| 698 | Nitration | HIQIPKLYTSNVTWD EEECCEEEECCCCCC | 17.78 | 12097137 | |
| 745 | Phosphorylation | KSRQNLQSPTSSRAT HCCCCCCCCCCCCCE | 33.06 | 22817900 | |
| 868 | Phosphorylation | ALCQPSEYSKWKFTN HHHCCHHHHCCCCCC | 21.64 | 22817900 | |
| 892 | Phosphorylation | EFPSLRVSAGFLLSQ HCCCCCCCCCHHHHC | 19.08 | - | |
| 898 | Phosphorylation | VSAGFLLSQLPILKP CCCCHHHHCCCCCCC | 31.64 | - | |
| 911 | Phosphorylation | KPRFYSISSSRDHTP CCCEEECCCCCCCCC | 19.13 | 24905233 | |
| 912 | Phosphorylation | PRFYSISSSRDHTPT CCEEECCCCCCCCCC | 27.94 | 24905233 | |
| 913 | Phosphorylation | RFYSISSSRDHTPTE CEEECCCCCCCCCCE | 34.63 | 24905233 | |
| 1055 | Phosphorylation | LPGKPKVYVQDILRQ CCCCCEEHHHHHHHH | 9.87 | 22817900 | |
| 1123 | Phosphorylation | QLKSQKRYHEDIFGA HHHHCCCCCCCCCCC | 19.32 | - | |
| 1134 | Phosphorylation | IFGAVFPYEAKKDRV CCCCCCCCCCCCCCE | 19.63 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 151 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| 234 | S | Phosphorylation | Kinase | PKA | - | Uniprot |
| 578 | S | Phosphorylation | Kinase | PKA | - | Uniprot |
| 745 | S | Phosphorylation | Kinase | MAPK3 | P27361 | GPS |
| 892 | S | Phosphorylation | Kinase | PKA | - | Uniprot |
| 1055 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| - | K | Ubiquitination | E3 ubiquitin ligase | STUB1 | Q9UNE7 | PMID:19362296 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOS2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOS2_HUMAN !! | ||||||
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