SPSB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPSB2_HUMAN
• UniProt AC: Q99619
• Protein Name: SPRY domain-containing SOCS box protein 2
• Gene Name: SPSB2
• Organism: Homo sapiens (Human).
• Sequence Length: 263
• Subcellular Localization: Cytoplasm .
• Protein Description: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Ubiquitination	RRHGWNPKDCSENIE CCCCCCHHHCCCCEE	69.06	33845483
54	Phosphorylation	GWNPKDCSENIEVKE CCCHHHCCCCEEEEE	43.76	-
65	Phosphorylation	EVKEGGLYFERRPVA EEEECCEEEEECCCC	13.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPSB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPSB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPSB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOS2_HUMAN	NOS2	physical	21199876
NOS2_HUMAN	NOS2	physical	21549100
NOS2_HUMAN	NOS2	physical	20603330
DDX4_HUMAN	DDX4	physical	20561531
PAWR_HUMAN	PAWR	physical	20561531
DDX4_MOUSE	Ddx4	physical	20561531
ELOC_HUMAN	TCEB1	physical	19159283
A4_HUMAN	APP	physical	21832049
CUL5_HUMAN	CUL5	physical	15601820
RBX2_HUMAN	RNF7	physical	15601820
ELOB_HUMAN	TCEB2	physical	15601820
ELOC_HUMAN	TCEB1	physical	15601820
ANM1_HUMAN	PRMT1	physical	23455924
EPHB2_HUMAN	EPHB2	physical	26186194
TTC1_HUMAN	TTC1	physical	26186194
CUL5_HUMAN	CUL5	physical	26186194
ARHGA_HUMAN	ARHGEF10	physical	26186194
P55G_HUMAN	PIK3R3	physical	25814554
EPHB2_HUMAN	EPHB2	physical	28514442
CUL5_HUMAN	CUL5	physical	28514442
TTC1_HUMAN	TTC1	physical	28514442
ARHGA_HUMAN	ARHGEF10	physical	28514442
NOS2_HUMAN	NOS2	physical	28549582

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.