DDX4_HUMAN - dbPTM
DDX4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DDX4_HUMAN
UniProt AC Q9NQI0
Protein Name Probable ATP-dependent RNA helicase DDX4
Gene Name DDX4
Organism Homo sapiens (Human).
Sequence Length 724
Subcellular Localization Cytoplasm . Cytoplasm, perinuclear region . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Protein Description ATP-dependent RNA helicase required during spermatogenesis. [PubMed: 10920202]
Protein Sequence MGDEDWEAEINPHMSSYVPIFEKDRYSGENGDNFNRTPASSSEMDDGPSRRDHFMKSGFASGRNFGNRDAGECNKRDNTSTMGGFGVGKSFGNRGFSNSRFEDGDSSGFWRESSNDCEDNPTRNRGFSKRGGYRDGNNSEASGPYRRGGRGSFRGCRGGFGLGSPNNDLDPDECMQRTGGLFGSRRPVLSGTGNGDTSQSRSGSGSERGGYKGLNEEVITGSGKNSWKSEAEGGESSDTQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIVAPTRELVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQDVPAWLEEIAFSTYIPGFSGSTRGNVFASVDTRKGKSTLNTAGFSSSQAPNPVDDESWD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11 (in isoform 3)Phosphorylation-16.36-
11PhosphorylationEDWEAEINPHMSSYV
CHHHHHCCCCHHHCC		16.36-
14 (in isoform 3)Phosphorylation-2.76-
14PhosphorylationEAEINPHMSSYVPIF
HHHCCCCHHHCCEEE		2.76-
37PhosphorylationNGDNFNRTPASSSEM
CCCCCCCCCCCCCCC		25.06-
75AcetylationRDAGECNKRDNTSTM
CCCCCCCCCCCCCCC		73.1730588079
77 (in isoform 3)Phosphorylation-65.45-
77PhosphorylationAGECNKRDNTSTMGG
CCCCCCCCCCCCCCC		65.45-
80 (in isoform 3)Phosphorylation-23.74-
80PhosphorylationCNKRDNTSTMGGFGV
CCCCCCCCCCCCCCC		23.74-
89AcetylationMGGFGVGKSFGNRGF
CCCCCCCCCCCCCCC		39.9630588085
90PhosphorylationGGFGVGKSFGNRGFS
CCCCCCCCCCCCCCC		32.24-
133PhosphorylationGFSKRGGYRDGNNSE
CCCCCCCCCCCCCCC		14.35-
139PhosphorylationGYRDGNNSEASGPYR
CCCCCCCCCCCCCCC		38.24-
166UbiquitinationGFGLGSPNNDLDPDE
CCCCCCCCCCCCHHH		57.2421987572
178UbiquitinationPDECMQRTGGLFGSR
HHHHHHHHCCCCCCC		20.7921987572
186UbiquitinationGGLFGSRRPVLSGTG
CCCCCCCCCCEECCC		27.6321987572
190UbiquitinationGSRRPVLSGTGNGDT
CCCCCCEECCCCCCC		34.2521987572
192UbiquitinationRRPVLSGTGNGDTSQ
CCCCEECCCCCCCCC		24.8921987572
198UbiquitinationGTGNGDTSQSRSGSG
CCCCCCCCCCCCCCC		30.7921987572
204UbiquitinationTSQSRSGSGSERGGY
CCCCCCCCCCCCCCC		40.1521987572
212UbiquitinationGSERGGYKGLNEEVI
CCCCCCCCCCCCEEE		61.2621987572
222PhosphorylationNEEVITGSGKNSWKS
CCEEECCCCCCCCCC		37.63-
224UbiquitinationEVITGSGKNSWKSEA
EEECCCCCCCCCCCC		49.8921987572
226PhosphorylationITGSGKNSWKSEAEG
ECCCCCCCCCCCCCC		39.09-
237PhosphorylationEAEGGESSDTQGPKV
CCCCCCCCCCCCCEE		40.1324114839
283AcetylationVEVSGHDAPPAILTF
EEECCCCCCCEEEEH		13.2919608861
312PhosphorylationKAGYTKLTPVQKYSI
HCCCCCCCCCCCCCC		23.99-
334PhosphorylationDLMACAQTGSGKTAA
CCHHHHHCCCCHHHH		18.1320873877
336PhosphorylationMACAQTGSGKTAAFL
HHHHHCCCCHHHHHH		40.2720873877
339PhosphorylationAQTGSGKTAAFLLPI
HHCCCCHHHHHHHHH		27.09-
398AcetylationGTCVRAVVIYGGTQL
CCCCEEEEEECCCHH		2.4519608861
400PhosphorylationCVRAVVIYGGTQLGH
CCEEEEEECCCHHHH		9.6324667141
408PhosphorylationGGTQLGHSIRQIVQG
CCCHHHHHHHHHHHH		20.0520068231
412AcetylationLGHSIRQIVQGCNIL
HHHHHHHHHHHCCEE		1.4719608861
432AcetylationRLMDIIGKEKIGLKQ
HHHHHHCCCCCCCHH		45.4819608861
442PhosphorylationIGLKQIKYLVLDEAD
CCCHHCEEEEEEHHH		12.0428152594
465PhosphorylationPEMKKLISCPGMPSK
HHHHHHHCCCCCCCH		25.3720068231
471PhosphorylationISCPGMPSKEQRQTL
HCCCCCCCHHHHHHH		39.6720068231
530AcetylationGQFSKREKLVEILRN
CCCCCHHHHHHHHHH		62.9620167786
549O-linked_GlycosylationRTMVFVETKKKADFI
CEEEEEEECCHHHHE		42.7530379171
722PhosphorylationPNPVDDESWD-----
CCCCCCCCCC-----		43.47-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DDX4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DDX4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DDX4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DDX4_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DDX4_HUMAN

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Related Literatures of Post-Translational Modification

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