DDX4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX4_MOUSE
• UniProt AC: Q61496
• Protein Name: ATP-dependent RNA helicase DDX4 {ECO:0000305|PubMed:28633017}
• Gene Name: Ddx4 {ECO:0000312|MGI:MGI:102670}
• Organism: Mus musculus (Mouse).
• Sequence Length: 702
• Subcellular Localization: Cytoplasm . Cytoplasm, perinuclear region . Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
• Protein Description: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. [PubMed: 20439430]
• Protein Sequence: MGDEDWEAEILKPHVSSYVPVFEKDKYSSGANGDTFNRTSASSDIGESSKKENTSTTGGFGRGKGFGNRGFLNNKFEEGDSSGFWKESNNDCEDNQTRSRGFSKRGGCQDGNDSEASGPFRRGGRGSFRGCRGGFGLGRPNSESDQDQGTQRGGGLFGSRKPAASDSGNGDTYQSRSGSGRGGYKGLNEEVVTGSGKNSWKSETEGGESSDSQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIVLAGRDLMACAQTGSGKTAAFLLPILAHMMRDGITASRFKELQEPECIIVAPTRELINQIYLEARKFSFGTCVRAVVIYGGTQFGHSVRQIVQGCNILCATPGRLMDIIGKEKIGLKQVKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLLFSATFPEEIQRLAGDFLKSSYLFVAVGQVGGACRDVQQTILQVGQYSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRCGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDTDSDNHLAQPLVKVLSDAQQDVPAWLEEIAFSTYVPPSFSSSTRGGAVFASVDTRKNYQGKHTLNTAGISSSQAPNPVDDESWD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	KKENTSTTGGFGRGK CCCCCCCCCCCCCCC	34.77	22705319
105	Methylation	RSRGFSKRGGCQDGN CCCCCCCCCCCCCCC	45.60	-
114	Phosphorylation	GCQDGNDSEASGPFR CCCCCCCCCCCCCCC	38.78	-
117	Phosphorylation	DGNDSEASGPFRRGG CCCCCCCCCCCCCCC	42.84	-
152	Methylation	DQDQGTQRGGGLFGS CCCCCCCCCCCCCCC	45.63	-
160	Methylation	GGGLFGSRKPAASDS CCCCCCCCCCCCCCC	49.72	-
175	Phosphorylation	GNGDTYQSRSGSGRG CCCCCCCCCCCCCCC	20.28	17203969
177	Phosphorylation	GDTYQSRSGSGRGGY CCCCCCCCCCCCCCC	42.42	17203969
193	Phosphorylation	GLNEEVVTGSGKNSW CCCCEEECCCCCCCC	30.70	21183079
195	Phosphorylation	NEEVVTGSGKNSWKS CCEEECCCCCCCCCC	36.91	25293948
199	Phosphorylation	VTGSGKNSWKSETEG ECCCCCCCCCCCCCC	39.09	19060867
202	Phosphorylation	SGKNSWKSETEGGES CCCCCCCCCCCCCCC	43.42	19060867
204	Phosphorylation	KNSWKSETEGGESSD CCCCCCCCCCCCCCC	47.20	21183079
209	Phosphorylation	SETEGGESSDSQGPK CCCCCCCCCCCCCCC	42.60	25293948
210	Phosphorylation	ETEGGESSDSQGPKV CCCCCCCCCCCCCCE	36.66	25293948
212	Phosphorylation	EGGESSDSQGPKVTY CCCCCCCCCCCCEEE	38.70	25293948
307	Phosphorylation	DLMACAQTGSGKTAA CCHHHHHCCCCHHHH	18.13	24759943
309	Phosphorylation	MACAQTGSGKTAAFL HHHHHCCCCHHHHHH	40.27	24759943
405	Acetylation	RLMDIIGKEKIGLKQ HHHHHHCCCCCCCCC	45.48	22650239
435	Acetylation	GFGPEMKKLISCPGM CCCHHHHHHHCCCCC	50.14	19844999
700	Phosphorylation	PNPVDDESWD----- CCCCCCCCCC-----	43.47	28633017

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RANB9_MOUSE	Ranbp9	physical	14648869

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.