RANB9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RANB9_MOUSE
• UniProt AC: P69566
• Protein Name: Ran-binding protein 9 {ECO:0000305}
• Gene Name: Ranbp9 {ECO:0000312|MGI:MGI:1928741}
• Organism: Mus musculus (Mouse).
• Sequence Length: 653
• Subcellular Localization: Cytoplasm . Nucleus . The unphosphorylated form is predominantly cytoplasmic (By similarity). A phosphorylated form is associated with the plasma membrane (By similarity). Perinuclear in spermatids (PubMed:14648869).
• Protein Description: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (By similarity). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity)..
• Protein Sequence: MSGQPPPPPPQQQPPPPPPPASAAAPATAPPGLAVGPGPAAGVPVPGLAAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGLSQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGIAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGDREGEWQTMIQKMVSSYLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEAIETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRPFSSPSMSPSHGMSIHSLAPGKSSTAHFSGFESCSNGVISNKAHQSYCHSKHQLSSLTVPELNSLNVSRSQQVNNFTSNDVDMETDHYSNGVGETSSNGFLNGSSKHDHEMEDCDTEMEVDCSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRECGKNTANKKMLKDAFSLLAYSDPWNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARSGVGSCAFATVEDYLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Acetylation	RSWSPKDKFSYIGLS CCCCCCCCCCEEEEC	42.19	23236377
330	Acetylation	LEELASIKNRQRIQK HHHHHHHCCHHHHHH	43.51	-
330	Ubiquitination	LEELASIKNRQRIQK HHHHHHHCCHHHHHH	43.51	-
337	Ubiquitination	KNRQRIQKLVLAGRM CCHHHHHHHHHCCCH	37.89	-
392	Phosphorylation	VRCLGGRSPKSQDSY EEECCCCCCCCCCCC	39.70	22324799
395	Phosphorylation	LGGRSPKSQDSYPVS CCCCCCCCCCCCCCC	42.47	25293948
398	Phosphorylation	RSPKSQDSYPVSPRP CCCCCCCCCCCCCCC	24.57	26643407
399	Phosphorylation	SPKSQDSYPVSPRPF CCCCCCCCCCCCCCC	18.88	25293948
402	Phosphorylation	SQDSYPVSPRPFSSP CCCCCCCCCCCCCCC	15.64	21082442
407	Phosphorylation	PVSPRPFSSPSMSPS CCCCCCCCCCCCCCC	43.98	21082442
408	Phosphorylation	VSPRPFSSPSMSPSH CCCCCCCCCCCCCCC	22.75	21082442
410	Phosphorylation	PRPFSSPSMSPSHGM CCCCCCCCCCCCCCC	33.56	25263469
412	Phosphorylation	PFSSPSMSPSHGMSI CCCCCCCCCCCCCCC	27.82	21082442
414	Phosphorylation	SSPSMSPSHGMSIHS CCCCCCCCCCCCCCC	25.93	26643407
418	Phosphorylation	MSPSHGMSIHSLAPG CCCCCCCCCCCCCCC	23.03	26643407
421	Phosphorylation	SHGMSIHSLAPGKSS CCCCCCCCCCCCCCC	25.26	26643407
459	Phosphorylation	CHSKHQLSSLTVPEL CCCHHHHHCCCHHHH	19.41	27841257
460	Phosphorylation	HSKHQLSSLTVPELN CCHHHHHCCCHHHHC	36.33	18846507
462	Phosphorylation	KHQLSSLTVPELNSL HHHHHCCCHHHHCCC	35.64	18846507
468	Phosphorylation	LTVPELNSLNVSRSQ CCHHHHCCCCCCHHH	33.67	18846507
472	Phosphorylation	ELNSLNVSRSQQVNN HHCCCCCCHHHHHCC	25.74	18846507
520	Phosphorylation	HEMEDCDTEMEVDCS CCCCCCCCCCEECHH	43.49	26525534

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RANB9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RANB9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RANB9_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDX4_MOUSE	Ddx4	physical	14648869
CSN5_MOUSE	Cops5	physical	23926111

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.