HKDC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HKDC1_HUMAN
• UniProt AC: Q2TB90
• Protein Name: Putative hexokinase HKDC1
• Gene Name: HKDC1
• Organism: Homo sapiens (Human).
• Sequence Length: 917
• Protein Sequence: MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIWTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQQAQKEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Acetylation	AFYFSKLKEDQIKKV HHHHHHCCHHHHHHH	64.08	24431307
32	Phosphorylation	FLYHMRLSDDTLLDI HHHHCCCCCHHHHHH	24.07	24719451
102	Ubiquitination	VQVAEEGKRHVQMES EEEECCCCCCEEEEC	42.48	-
153	Phosphorylation	KKLPLGLTFSFPCRQ CCCCCCEEEEEECCC	18.55	28857561
155	Phosphorylation	LPLGLTFSFPCRQTK CCCCEEEEEECCCCC	24.04	28857561
170	Phosphorylation	LEEGVLLSWTKKFKA CCCCCEEEEHHHCHH	28.65	28857561
172	Phosphorylation	EGVLLSWTKKFKARG CCCEEEEHHHCHHCC	22.45	28857561
173	Acetylation	GVLLSWTKKFKARGV CCEEEEHHHCHHCCC	50.37	20167786
174	Acetylation	VLLSWTKKFKARGVQ CEEEEHHHCHHCCCC	44.73	20167786
183	Phosphorylation	KARGVQDTDVVSRLT HHCCCCCHHHHHHHH	17.38	28857561
290	Ubiquitination	LGSLNPGKQLFEKMI CCCCCCCHHHHHHHH	45.12	-
324	Ubiquitination	GLLFGGEKSSALHTK CCCCCCCCCCCCCCC	53.65	-
330	Phosphorylation	EKSSALHTKGKIETR CCCCCCCCCCCCCHH	42.20	-
333	Acetylation	SALHTKGKIETRHVA CCCCCCCCCCHHHHH	38.64	164471
408	Phosphorylation	KKVERLRTTVGMDGT CCHHHHHHEECCCCC	30.35	22210691
409	Phosphorylation	KVERLRTTVGMDGTL CHHHHHHEECCCCCE	14.50	22210691
415	Phosphorylation	TTVGMDGTLYKIHPQ HEECCCCCEEECCCC	23.73	22210691
417	Phosphorylation	VGMDGTLYKIHPQYP ECCCCCEEECCCCCC	14.03	-
418	Ubiquitination	GMDGTLYKIHPQYPK CCCCCEEECCCCCCH	37.34	-
445	Phosphorylation	CDVRFLLSESGSTKG CCEEEEECCCCCCCH	31.68	25002506
447	Phosphorylation	VRFLLSESGSTKGAA EEEEECCCCCCCHHH	34.37	25002506
449	Phosphorylation	FLLSESGSTKGAAMV EEECCCCCCCHHHHH	35.90	28857561
450	Phosphorylation	LLSESGSTKGAAMVT EECCCCCCCHHHHHH	36.70	25002506
457	Phosphorylation	TKGAAMVTAVASRVQ CCHHHHHHHHHHHHH	11.43	28857561
457	O-linked_Glycosylation	TKGAAMVTAVASRVQ CCHHHHHHHHHHHHH	11.43	OGP
500	Ubiquitination	AELEYGLKKKSHGLA HHHHHHHCCCCCCEE	54.51	-
502	Ubiquitination	LEYGLKKKSHGLATV HHHHHCCCCCCEEEE	46.20	-
503	Phosphorylation	EYGLKKKSHGLATVR HHHHCCCCCCEEEEE	31.50	-
508	Phosphorylation	KKSHGLATVRMLPTY CCCCCEEEEEECCEE	17.43	-
514	Phosphorylation	ATVRMLPTYVCGLPD EEEEECCEEECCCCC	25.32	-
523	Phosphorylation	VCGLPDGTEKGKFLA ECCCCCCCCCCCEEE	41.73	28857561
527	Acetylation	PDGTEKGKFLALDLG CCCCCCCCEEEEECC	48.55	21339330
544	Acetylation	NFRVLLVKIRSGRRS CEEEEEEEECCCCCC	32.16	30589271
609	Phosphorylation	SFPCRQMSIDKGTLI EEEEEEEEECCCCEE	21.21	28857561
732	Phosphorylation	DTEVDEGSLNPGKQR CCCCCCCCCCCCHHH	23.95	28857561
737 (in isoform 2)	Ubiquitination	-	32.62	21906983
737 (in isoform 1)	Ubiquitination	-	32.62	21906983
737	Ubiquitination	EGSLNPGKQRYEKMT CCCCCCCHHHHHHHC	32.62	2190698
748	Phosphorylation	EKMTSGMYLGEIVRQ HHHCCCCHHHHHHHH	18.32	18452278
772	Phosphorylation	LLFRGQISERLRTRG EEECCHHHHHHHHCC	14.58	21406692
787	Phosphorylation	IFETKFLSQIESDRL CCCHHHHHHHHHHHH	32.04	28857561
791	Phosphorylation	KFLSQIESDRLALLQ HHHHHHHHHHHHHHH	29.65	24076635
811	Phosphorylation	QQLGLDSTCEDSIVV HHHCCCCCCCCCCHH	21.41	26503514
856	Phosphorylation	GLEHLRITVGVDGTL CCCEEEEEEECCCCE	12.55	27811184
862	Phosphorylation	ITVGVDGTLYKLHPH EEEECCCCEECCCHH	23.58	27811184
864	Phosphorylation	VGVDGTLYKLHPHFS EECCCCEECCCHHHH	16.02	27811184
877	Phosphorylation	FSRILQETVKELAPR HHHHHHHHHHHHHCC	24.74	28857561
888	Phosphorylation	LAPRCDVTFMLSEDG HHCCCCEEEEECCCC	7.06	28176443
892	Phosphorylation	CDVTFMLSEDGSGKG CCEEEEECCCCCCHH	23.12	28176443
896	Phosphorylation	FMLSEDGSGKGAALI EEECCCCCCHHHHHH	50.05	28176443

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HKDC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HKDC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HKDC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HKDC1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.