TNAP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNAP2_HUMAN
• UniProt AC: Q03169
• Protein Name: Tumor necrosis factor alpha-induced protein 2
• Gene Name: TNFAIP2
• Organism: Homo sapiens (Human).
• Sequence Length: 654
• Protein Description: May play a role as a mediator of inflammation and angiogenesis..
• Protein Sequence: MSEASSEDLVPPLEAGAAPYREEEEAAKKKKEKKKKSKGLANVFCVFTKGKKKKGQPSSAEPEDAAGSRQGLDGPPPTVEELKAALERGQLEAARPLLALERELAAAAAAGGVSEEELVRRQSKVEALYELLRDQVLGVLRRPLEAPPERLRQALAVVAEQEREDRQAAAAGPGTSGLAATRPRRWLQLWRRGVAEAAEERMGQRPAAGAEVPESVFLHLGRTMKEDLEAVVERLKPLFPAEFGVVAAYAESYHQHFAAHLAAVAQFELCERDTYMLLLWVQNLYPNDIINSPKLVGELQGMGLGSLLPPRQIRLLEATFLSSEAANVRELMDRALELEARRWAEDVPPQRLDGHCHSELAIDIIQITSQAQAKAESITLDLGSQIKRVLLVELPAFLRSYQRAFNEFLERGKQLTNYRANVIANINNCLSFRMSMEQNWQVPQDTLSLLLGPLGELKSHGFDTLLQNLHEDLKPLFKRFTHTRWAAPVETLENIIATVDTRLPEFSELQGCFREELMEALHLHLVKEYIIQLSKGRLVLKTAEQQQQLAGYILANADTIQHFCTQHGSPATWLQPALPTLAEIIRLQDPSAIKIEVATYATCYPDFSKGHLSAILAIKGNLSNSEVKRIRSILDVSMGAQEPSRPLFSLIKVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEASSEDL ------CCCCCCCCC	41.70	25159151
5	Phosphorylation	---MSEASSEDLVPP ---CCCCCCCCCCCC	30.15	28355574
6	Phosphorylation	--MSEASSEDLVPPL --CCCCCCCCCCCCC	42.02	25056879
37	Phosphorylation	KKEKKKKSKGLANVF HHHHHHHHCCCCHHH	40.61	21712546
38	Ubiquitination	KEKKKKSKGLANVFC HHHHHHHCCCCHHHH	67.81	33845483
49	Ubiquitination	NVFCVFTKGKKKKGQ HHHHEEECCCCCCCC	58.21	33845483
68	Phosphorylation	EPEDAAGSRQGLDGP CCCCCCCCCCCCCCC	19.39	28985074
83	Ubiquitination	PPTVEELKAALERGQ CCCHHHHHHHHHHCC	34.59	29967540
114	Phosphorylation	AAAAGGVSEEELVRR HHHHCCCCHHHHHHH	42.43	-
123	Phosphorylation	EELVRRQSKVEALYE HHHHHHHHHHHHHHH	36.54	30108239
124	Ubiquitination	ELVRRQSKVEALYEL HHHHHHHHHHHHHHH	35.44	-
129	Phosphorylation	QSKVEALYELLRDQV HHHHHHHHHHHHHHH	16.16	27642862
175	Phosphorylation	AAAAGPGTSGLAATR HHHCCCCCCHHHCCC	23.82	24719451
225	Ubiquitination	LHLGRTMKEDLEAVV HHHCCCHHHHHHHHH	47.68	33845483
387	Ubiquitination	LDLGSQIKRVLLVEL EECHHHHHHHHHHHH	28.90	33845483
413	Ubiquitination	NEFLERGKQLTNYRA HHHHHHHHHHCCHHH	48.64	29901268
474	Ubiquitination	QNLHEDLKPLFKRFT HHHHHHHHHHHHHCC	52.58	33845483
478	Acetylation	EDLKPLFKRFTHTRW HHHHHHHHHCCCCCC	55.04	7406549
529	Phosphorylation	HLHLVKEYIIQLSKG HHHHHHHHHHHHHCC	9.52	-
599	Phosphorylation	AIKIEVATYATCYPD CEEEEEEEEEECCCC	20.90	-
602	Phosphorylation	IEVATYATCYPDFSK EEEEEEEECCCCCCC	11.36	-
628	2-Hydroxyisobutyrylation	NLSNSEVKRIRSILD CCCHHHHHHHHHHHH	37.75	-
628	Ubiquitination	NLSNSEVKRIRSILD CCCHHHHHHHHHHHH	37.75	33845483
632	Phosphorylation	SEVKRIRSILDVSMG HHHHHHHHHHHHHCC	25.73	28355574
637	Phosphorylation	IRSILDVSMGAQEPS HHHHHHHHCCCCCCC	15.92	28555341
649	Phosphorylation	EPSRPLFSLIKVG-- CCCCCCCCEEECC--	36.55	24719451
652	Ubiquitination	RPLFSLIKVG----- CCCCCEEECC-----	46.31	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNAP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNAP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNAP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOPB1_HUMAN	TOPBP1	physical	22939629
VPS36_HUMAN	VPS36	physical	22939629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.