dbPTM

PARP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PARP4_HUMAN
UniProt AC	Q9UKK3
Protein Name	Poly [ADP-ribose] polymerase 4
Gene Name	PARP4
Organism	Homo sapiens (Human).
Sequence Length	1724
Subcellular Localization	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Also found in the nucleus, associated with mitotic spindles.
Protein Description
Protein Sequence	MVMGIFANCIFCLKVKYLPQQQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQLNSIQKNHVHIANPDFIWKSIREKRLLDVKNYDPYKPLDITPPPDQKASSSEVKTEGLCPDSATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVELQCSRDSRDCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPEATQLASEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISLNDVSKAEGILLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGLLAKKADLCQLIRDMVNVCETNLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRVNETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVTTDFEDDEFVVYKTNQVKMKYIIKFSMPGDQIKDFHPSDHTELEEYRPEFSNFSKVEDYQLPDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGNLPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYLPRMWVEKHPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIALHALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTMAAEFIMSATPTMGNTDFWKTLRYLSLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCGAGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFLNDRLLVYGFIPHCTQATLCALIQEKEFRTMVSTTELQKTTGTMIHKLAARALIRDYEDGILHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDENESPFPDIPKVSELIAKEDVDFLPYMSWQGEPQEAVRNQSLLASSEWPELRLSKRKHRKIPFSKRKMELSQPEVSEDFEEDGLGVLPAFTSNLERGGVEKLLDLSWTESCKPTATEPLFKKVSPWETSTSSFFPILAPAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIPQSASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQLHFSLPTDPDPIRGFGSYHPSASSPFHFQPSAASLTANLRLPMASALPEALCSQSRTTPVDLCLLEESVGSLEGSRCPVFAFQSSDTESDELSEVLQDSCFLQIKCDTKDDSILCFLEVKEEDEIVCIQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTNGLHSFLKQKGIQSLGVKGRECLLDLIATMLVLQFIRTRLEKEGIVFKSLMKMDDASISRNIPWAFEAIKQASEWVRRTEGQYPSICPRLELGNDWDSATKQLLGLQPISTVSPLHRVLHYSQG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	CIFCLKVKYLPQQQK HHHHHHHHCCCHHHH	39.21	29967540
17	Phosphorylation	IFCLKVKYLPQQQKK HHHHHHHCCCHHHHH	26.97	-
23	Ubiquitination	KYLPQQQKKKLQTDI HCCCHHHHHHHCHHH	47.76	29967540
28	Phosphorylation	QQKKKLQTDIKENGG HHHHHHCHHHHHCCC	50.56	-
31	Ubiquitination	KKLQTDIKENGGKFS HHHCHHHHHCCCEEE	48.19	-
63	Phosphorylation	LSQYQLNSIQKNHVH HHHHHCHHHHHCCCE	34.68	24719451
79	Ubiquitination	ANPDFIWKSIREKRL CCHHHHHHHHHHHCC	31.05	29967540
84	Ubiquitination	IWKSIREKRLLDVKN HHHHHHHHCCCCCCC	38.20	23503661
90	Ubiquitination	EKRLLDVKNYDPYKP HHCCCCCCCCCCCCC	49.83	21906983
92	Phosphorylation	RLLDVKNYDPYKPLD CCCCCCCCCCCCCCC	16.75	23403867
95	Phosphorylation	DVKNYDPYKPLDITP CCCCCCCCCCCCCCC	23.49	23927012
96	Ubiquitination	VKNYDPYKPLDITPP CCCCCCCCCCCCCCC	44.48	21906983
101	Phosphorylation	PYKPLDITPPPDQKA CCCCCCCCCCCCCCC	29.43	25159151
107	Ubiquitination	ITPPPDQKASSSEVK CCCCCCCCCCCCCCC	58.58	33845483
111	Phosphorylation	PDQKASSSEVKTEGL CCCCCCCCCCCCCCC	43.86	23828894
122	Phosphorylation	TEGLCPDSATEEEDT CCCCCCCCCCCCCCC	23.41	26657352
124	Phosphorylation	GLCPDSATEEEDTVE CCCCCCCCCCCCCEE	48.13	25159151
129	Phosphorylation	SATEEEDTVELTEFG CCCCCCCCEEEEHHH	21.11	26657352
131	Ubiquitination	TEEEDTVELTEFGMQ CCCCCCEEEEHHHCC	52.66	23503661
137	Ubiquitination	VELTEFGMQNVEIPH EEEEHHHCCCCCCCC	2.96	22817900
143	Ubiquitination	GMQNVEIPHLPQDFE HCCCCCCCCCCCCCH	14.95	22817900
206	Ubiquitination	RRQFAIKKTSEDASE HHHHEEECCCHHHHH	51.69	29967540
214	Phosphorylation	TSEDASEYFENYIEE CCHHHHHHHHHHHHH	17.44	25884760
218	Phosphorylation	ASEYFENYIEELKKQ HHHHHHHHHHHHHHC	11.51	25884760
223	Ubiquitination	ENYIEELKKQGFLLR HHHHHHHHHCCCEEH	46.46	21906983
224	Ubiquitination	NYIEELKKQGFLLRE HHHHHHHHCCCEEHH	69.17	22817900
270	Ubiquitination	VSDLVEMIWAEALGH HHHHHHHHHHHHHHH	1.67	22817900
271	Ubiquitination	SDLVEMIWAEALGHL HHHHHHHHHHHHHHH	6.17	22817900
296	Ubiquitination	ISLNDVSKAEGILLL CCHHHCCHHHHHHHH	50.75	-
305	Ubiquitination	EGILLLVKAALKNGE HHHHHHHHHHHHCCC	28.10	21906983
309	Ubiquitination	LLVKAALKNGETAEQ HHHHHHHHCCCHHHH	59.17	21906983
331	Ubiquitination	FYRLIPHKGTMPKEV HHHHCCCCCCCCCCC	51.20	23000965
333	Phosphorylation	RLIPHKGTMPKEVNL HHCCCCCCCCCCCCH	34.79	24706070
336	Ubiquitination	PHKGTMPKEVNLGLL CCCCCCCCCCCHHHH	64.57	23000965
345	2-Hydroxyisobutyrylation	VNLGLLAKKADLCQL CCHHHHHHHHHHHHH	48.76	-
346	Ubiquitination	NLGLLAKKADLCQLI CHHHHHHHHHHHHHH	41.34	-
352	Ubiquitination	KKADLCQLIRDMVNV HHHHHHHHHHHHHHH	3.19	22817900
356	Ubiquitination	LCQLIRDMVNVCETN HHHHHHHHHHHHHHC	1.37	22817900
362	Phosphorylation	DMVNVCETNLSKPNP HHHHHHHHCCCCCCC	36.01	-
365	Phosphorylation	NVCETNLSKPNPPSL HHHHHCCCCCCCHHH	48.41	-
371	Phosphorylation	LSKPNPPSLAKYRAL CCCCCCHHHHHHHHH	42.06	-
378	Ubiquitination	SLAKYRALRCKIEHV HHHHHHHHHCCEEEH	4.96	23000965
383	Ubiquitination	RALRCKIEHVEQNTE HHHHCCEEEHHHCHH	27.63	23000965
397	Ubiquitination	EEFLRVRKEVLQNHH HHHHHHHHHHHHHCC	49.68	29967540
405	Phosphorylation	EVLQNHHSKSPVDVL HHHHHCCCCCCCCHH	27.55	29978859
406	Ubiquitination	VLQNHHSKSPVDVLQ HHHHCCCCCCCCHHH	55.19	-
423	Phosphorylation	RVGRVNETTEFLSKL ECCCCCHHHHHHHHH	26.82	20860994
424	Phosphorylation	VGRVNETTEFLSKLG CCCCCHHHHHHHHHC	20.68	20860994
429	Ubiquitination	ETTEFLSKLGNVRPL HHHHHHHHHCCCHHH	63.66	22817900
457	Ubiquitination	CRGLLLPKVVEDRGV HHHCCCCHHHHCCCC	59.90	29967540
467	Phosphorylation	EDRGVQRTDVGNLGS HCCCCCCCCCCCCCC	20.25	-
476	Ubiquitination	VGNLGSGIYFSDSLS CCCCCCCEEECCCCC	3.17	22817900
509	Ubiquitination	ICDVALGKCMDLHEK EEHHHHCCCCCCCCC	27.51	-
572	Ubiquitination	SMPGDQIKDFHPSDH CCCHHHHCCCCCCCC	49.02	29967540
594	Ubiquitination	PEFSNFSKVEDYQLP CCCCCCCCCCCCCCC	45.57	21906983
598	Phosphorylation	NFSKVEDYQLPDAKT CCCCCCCCCCCCCCC	9.84	27642862
604	Ubiquitination	DYQLPDAKTSSSTKA CCCCCCCCCCCCCCC	57.21	21906983
610	Ubiquitination	AKTSSSTKAGLQDAS CCCCCCCCCCCCCCC	42.26	29967540
629	Ubiquitination	PLEDVHIKGRIIDTV EHHHCEECCCHHHHC	27.53	-
635	Phosphorylation	IKGRIIDTVAQVIVF ECCCHHHHCCEEEEE	13.82	30576142
641	Ubiquitination	DTVAQVIVFQTYTNK HHCCEEEEEECCCCC	2.82	21963094
644	Phosphorylation	AQVIVFQTYTNKSHV CEEEEEECCCCCCCC	22.35	30576142
645	Phosphorylation	QVIVFQTYTNKSHVP EEEEEECCCCCCCCC	9.49	30576142
651	Ubiquitination	TYTNKSHVPIEAKYI CCCCCCCCCEEEEEE	7.06	22817900
656	Ubiquitination	SHVPIEAKYIFPLDD CCCCEEEEEEEECCC	26.53	29967540
664	Ubiquitination	YIFPLDDKAAVCGFE EEEECCCHHEECCEE	37.60	22817900
677	Ubiquitination	FEAFINGKHIVGEIK EEEECCCEEEEEEHH	26.18	-
711	Ubiquitination	YLMSQDAPDVFTVSV EEECCCCCCEEEEEE	46.73	22817900
768	Phosphorylation	LNENLQDTVEKICIK HHHHHHHHHHHHHHH	20.01	21815630
771	Ubiquitination	NLQDTVEKICIKEIG HHHHHHHHHHHHHHC	38.24	29967540
775	Ubiquitination	TVEKICIKEIGTKQS HHHHHHHHHHCCCCE	38.58	33845483
830	Phosphorylation	SLDSSGFSLHIGLSA CCCCCCEEEEEECCH	23.67	-
836	Phosphorylation	FSLHIGLSAAYLPRM EEEEEECCHHHCCHH	12.97	24719451
847	Ubiquitination	LPRMWVEKHPEKESE CCHHHHHHCCHHCCC	55.64	-
904	Phosphorylation	QIALHALSLVGEKQK HHHHHHHHHCCCHHH	23.07	-
926	Phosphorylation	TGYKELFSYPKHITS CCHHHHHCCCCCCCC	53.82	24719451
959	Phosphorylation	DFWKTLRYLSLLYPA HHHHHHHHHHHHCCC	12.07	23312004
961	Phosphorylation	WKTLRYLSLLYPARG HHHHHHHHHHCCCCC	13.85	23312004
964	Phosphorylation	LRYLSLLYPARGSRN HHHHHHHCCCCCCCC	10.51	23312004
969	Phosphorylation	LLYPARGSRNILLVS HHCCCCCCCCEEEEE	19.32	23312004
1006	Phosphorylation	LFACGIGSTANRHVL EEEECCCHHHHHHHH	23.56	28857561
1017	Phosphorylation	RHVLRILSQCGAGVF HHHHHHHHHCCCHHH	22.51	28857561
1030	Ubiquitination	VFEYFNAKSKHSWRK HHHHHCCCCCCHHHH	62.23	22505724
1031	Phosphorylation	FEYFNAKSKHSWRKQ HHHHCCCCCCHHHHH	32.94	22210691
1032	Ubiquitination	EYFNAKSKHSWRKQI HHHCCCCCCHHHHHH	40.74	-
1034	Phosphorylation	FNAKSKHSWRKQIED HCCCCCCHHHHHHHH	32.11	22210691
1037	Ubiquitination	KSKHSWRKQIEDQMT CCCCHHHHHHHHHHH	49.74	29967540
1044	Phosphorylation	KQIEDQMTRLCSPSC HHHHHHHHHHCCCCC	18.17	22210691
1048	Phosphorylation	DQMTRLCSPSCHSVS HHHHHHCCCCCCEEE	25.17	25159151
1050	Phosphorylation	MTRLCSPSCHSVSVK HHHHCCCCCCEEEEE	14.25	26699800
1053	Phosphorylation	LCSPSCHSVSVKWQQ HCCCCCCEEEEEHHH	22.03	26699800
1055	Phosphorylation	SPSCHSVSVKWQQLN CCCCCEEEEEHHHCC	22.46	26699800
1077	Ubiquitination	QAPAQVPSLFLNDRL HCCCCCCCEECCCCE	32.66	22505724
1109	Phosphorylation	IQEKEFRTMVSTTEL HHHHHHHHCCCCCCH	27.52	29759185
1112	Phosphorylation	KEFRTMVSTTELQKT HHHHHCCCCCCHHHH	20.84	-
1119	Phosphorylation	STTELQKTTGTMIHK CCCCHHHHHHHHHHH	19.93	20068231
1120	Phosphorylation	TTELQKTTGTMIHKL CCCHHHHHHHHHHHH	37.38	20068231
1122	Phosphorylation	ELQKTTGTMIHKLAA CHHHHHHHHHHHHHH	15.74	20068231
1126	Ubiquitination	TTGTMIHKLAARALI HHHHHHHHHHHHHHH	28.97	29967540
1151	Ubiquitination	NETSHEMKKQTLKSL CCCCHHHHHHHHHHH	38.45	22817900
1152	Ubiquitination	ETSHEMKKQTLKSLI CCCHHHHHHHHHHHH	47.40	22817900
1156	Ubiquitination	EMKKQTLKSLIIKLS HHHHHHHHHHHHHHH	46.75	22817900
1173	Phosphorylation	NSLITQFTSFVAVEK CCHHHEEECEEEEEE	16.07	-
1174	Phosphorylation	SLITQFTSFVAVEKR CHHHEEECEEEEEEC	21.00	-
1186	Phosphorylation	EKRDENESPFPDIPK EECCCCCCCCCCCCH	43.34	25159151
1193	Ubiquitination	SPFPDIPKVSELIAK CCCCCCCHHHHHHHH	59.74	29967540
1198	Ubiquitination	IPKVSELIAKEDVDF CCHHHHHHHHCCCCC	4.52	22817900
1199	Ubiquitination	PKVSELIAKEDVDFL CHHHHHHHHCCCCCC	23.08	22817900
1200	Ubiquitination	KVSELIAKEDVDFLP HHHHHHHHCCCCCCC	47.67	21906983
1203	Ubiquitination	ELIAKEDVDFLPYMS HHHHHCCCCCCCCCC	6.18	22817900
1223	Phosphorylation	QEAVRNQSLLASSEW HHHHHCCHHHHCCCC	28.97	25850435
1227	Phosphorylation	RNQSLLASSEWPELR HCCHHHHCCCCCHHH	28.85	25159151
1228	Phosphorylation	NQSLLASSEWPELRL CCHHHHCCCCCHHHH	37.77	28857561
1236	Phosphorylation	EWPELRLSKRKHRKI CCCHHHHHHCCCCCC	24.79	28355574
1247	Ubiquitination	HRKIPFSKRKMELSQ CCCCCCCCCCCCCCC	57.31	22817900
1253	Phosphorylation	SKRKMELSQPEVSED CCCCCCCCCCCCCCC	30.31	28348404
1288	Phosphorylation	VEKLLDLSWTESCKP HHHHHCCCCCCCCCC	31.45	25159151
1290	Phosphorylation	KLLDLSWTESCKPTA HHHCCCCCCCCCCCC	18.04	25106551
1292	Phosphorylation	LDLSWTESCKPTATE HCCCCCCCCCCCCCC	21.77	22199227
1294	Ubiquitination	LSWTESCKPTATEPL CCCCCCCCCCCCCCC	55.47	21906983
1296	Phosphorylation	WTESCKPTATEPLFK CCCCCCCCCCCCCCC	31.54	27080861
1298	Phosphorylation	ESCKPTATEPLFKKV CCCCCCCCCCCCCCC	40.38	27080861
1303	Ubiquitination	TATEPLFKKVSPWET CCCCCCCCCCCCCCC	61.01	29967540
1304	Ubiquitination	ATEPLFKKVSPWETS CCCCCCCCCCCCCCC	40.38	-
1306	Phosphorylation	EPLFKKVSPWETSTS CCCCCCCCCCCCCCC	32.92	28450419
1310	Phosphorylation	KKVSPWETSTSSFFP CCCCCCCCCCCCCCC	33.17	28450419
1311	Phosphorylation	KVSPWETSTSSFFPI CCCCCCCCCCCCCCC	18.12	28450419
1312	O-linked_Glycosylation	VSPWETSTSSFFPIL CCCCCCCCCCCCCCH	35.49	30059200
1312	Phosphorylation	VSPWETSTSSFFPIL CCCCCCCCCCCCCCH	35.49	28450419
1313	Phosphorylation	SPWETSTSSFFPILA CCCCCCCCCCCCCHH	25.56	28450419
1314	O-linked_Glycosylation	PWETSTSSFFPILAP CCCCCCCCCCCCHHH	30.87	30059200
1314	Phosphorylation	PWETSTSSFFPILAP CCCCCCCCCCCCHHH	30.87	28450419
1332	Methylation	SYLPPTARAHSPASL HCCCCCCCCCCCCCC	35.00	115389225
1335	Phosphorylation	PPTARAHSPASLSFA CCCCCCCCCCCCCCC	22.60	23927012
1338	O-linked_Glycosylation	ARAHSPASLSFASYR CCCCCCCCCCCCCHH	28.12	30059200
1338	Phosphorylation	ARAHSPASLSFASYR CCCCCCCCCCCCCHH	28.12	23927012
1340	Phosphorylation	AHSPASLSFASYRQV CCCCCCCCCCCHHHH	19.10	23927012
1341	Ubiquitination	HSPASLSFASYRQVA CCCCCCCCCCHHHHH	6.76	21963094
1343	Phosphorylation	PASLSFASYRQVASF CCCCCCCCHHHHHCC	20.88	23927012
1344	Phosphorylation	ASLSFASYRQVASFG CCCCCCCHHHHHCCC	11.13	23403867
1349	Phosphorylation	ASYRQVASFGSAAPP CCHHHHHCCCCCCCC	31.14	26657352
1352	Phosphorylation	RQVASFGSAAPPRQF HHHHCCCCCCCCCCC	21.17	28387310
1425	Phosphorylation	GGFTTRPSAGTFPEL CCCCCCCCCCCCCCC	35.72	26657352
1428	Phosphorylation	TTRPSAGTFPELDSP CCCCCCCCCCCCCCC	35.42	26657352
1434	Phosphorylation	GTFPELDSPQLHFSL CCCCCCCCCCEEEEC	27.46	29255136
1440	Phosphorylation	DSPQLHFSLPTDPDP CCCCEEEECCCCCCC	23.77	29255136
1449	Methylation	PTDPDPIRGFGSYHP CCCCCCCCCCCCCCC	39.51	115389229
1476	Asymmetric dimethylarginine	ASLTANLRLPMASAL HHHCCCCCCCHHHHC	36.23	-
1476	Methylation	ASLTANLRLPMASAL HHHCCCCCCCHHHHC	36.23	24129315
1489	Phosphorylation	ALPEALCSQSRTTPV HCCHHHHCCCCCCCC	31.85	26074081
1491	Phosphorylation	PEALCSQSRTTPVDL CHHHHCCCCCCCCCE	18.46	26074081
1493	Phosphorylation	ALCSQSRTTPVDLCL HHHCCCCCCCCCEEE	40.47	30183078
1494	Phosphorylation	LCSQSRTTPVDLCLL HHCCCCCCCCCEEEE	21.87	22617229
1504	Phosphorylation	DLCLLEESVGSLEGS CEEEEECCCCCCCCC	23.54	22617229
1507	Phosphorylation	LLEESVGSLEGSRCP EEECCCCCCCCCCCC	22.53	22617229
1511	Phosphorylation	SVGSLEGSRCPVFAF CCCCCCCCCCCEEEE	22.72	30108239
1520	Phosphorylation	CPVFAFQSSDTESDE CCEEEEECCCCCCHH	24.59	26657352
1521	Phosphorylation	PVFAFQSSDTESDEL CEEEEECCCCCCHHH	37.46	27251275
1523	Phosphorylation	FAFQSSDTESDELSE EEEECCCCCCHHHHH	39.06	27251275
1525	Phosphorylation	FQSSDTESDELSEVL EECCCCCCHHHHHHH	38.18	26657352
1529	Phosphorylation	DTESDELSEVLQDSC CCCCHHHHHHHHHHC	24.50	27251275
1535	Phosphorylation	LSEVLQDSCFLQIKC HHHHHHHHCEEEEEE	8.20	24275569
1548	Phosphorylation	KCDTKDDSILCFLEV EECCCCCEEEEEEEE	27.82	-
1600	Phosphorylation	GLILNLNTNGLHSFL HEEEECCCCCHHHHH	33.55	-
1605	Phosphorylation	LNTNGLHSFLKQKGI CCCCCHHHHHHHHCC	37.00	24719451
1614	Phosphorylation	LKQKGIQSLGVKGRE HHHHCCHHCCCCHHH	25.77	-
1629	Phosphorylation	CLLDLIATMLVLQFI HHHHHHHHHHHHHHH	12.21	22817900
1648	Ubiquitination	EKEGIVFKSLMKMDD HHCCCEEEECCCCCC	31.61	29967540
1649	Phosphorylation	KEGIVFKSLMKMDDA HCCCEEEECCCCCCC	23.41	-
1710	Phosphorylation	LLGLQPISTVSPLHR HHCCCCCCCCCCHHH	29.46	30108239
1711	Phosphorylation	LGLQPISTVSPLHRV HCCCCCCCCCCHHHH	26.23	23927012
1713	Phosphorylation	LQPISTVSPLHRVLH CCCCCCCCCHHHHHH	23.10	23927012
1721	Phosphorylation	PLHRVLHYSQG---- CHHHHHHHCCC----	9.87	29514088
1722	Phosphorylation	LHRVLHYSQG----- HHHHHHHCCC-----	20.06	28355574

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PARP4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PARP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
122	Phosphorylation	122 (0)	S ⇒ N	rs9578751	Idiopathic intracranial hypertension	29608535
124	Phosphorylation	122 (2)	S ⇒ N	rs9578751	Idiopathic intracranial hypertension	29608535

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MVP_HUMAN	MVP	physical	11855821
MVP_HUMAN	MVP	physical	10477748
PRAF3_HUMAN	ARL6IP5	physical	22939629
TEP1_HUMAN	TEP1	physical	15169895
SMAD3_HUMAN	SMAD3	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PARP4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-101; SER-1236; SER-1335;SER-1504 AND SER-1507, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1335, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1629, AND MASSSPECTROMETRY.	18187866 [Abstract]