dbPTM

QPCTL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	QPCTL_HUMAN
UniProt AC	Q9NXS2
Protein Name	Glutaminyl-peptide cyclotransferase-like protein
Gene Name	QPCTL
Organism	Homo sapiens (Human).
Sequence Length	382
Subcellular Localization	Golgi apparatus membrane Single-pass type I membrane protein .
Protein Description	Responsible for the biosynthesis of pyroglutamyl peptides..
Protein Sequence	MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTEELPLGRELRVPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYLGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
106	O-linked_Glycosylation	RPLLVVRTPGSPGNL EEEEEEECCCCCCCH	22.01	OGP
140	O-linked_Glycosylation	ELDPFTASTPLGPVD EECCCCCCCCCCCCC	27.74	OGP
216	O-linked_Glycosylation	KKQAAPVTLQLLFLD HHHHCCEEEEEEEEC	14.02	OGP
253	Phosphorylation	LMESIPHSPGPTRIQ HHHHCCCCCCCHHHH	26.63	22798277
257	Phosphorylation	IPHSPGPTRIQAIEL CCCCCCCHHHHHHHH	46.44	-
344	O-linked_Glycosylation	PVLHLISTPFPAVWH CEEEEECCCCCCCCC	23.19	OGP
352	O-linked_Glycosylation	PFPAVWHTPADTEVN CCCCCCCCCCCCCCC	12.40	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of QPCTL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of QPCTL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of QPCTL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of QPCTL_HUMAN

Related Literatures of Post-Translational Modification