PAI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAI1_HUMAN
• UniProt AC: P05121
• Protein Name: Plasminogen activator inhibitor 1
• Gene Name: SERPINE1
• Organism: Homo sapiens (Human).
• Sequence Length: 402
• Subcellular Localization: Secreted .
• Protein Description: Serine protease inhibitor. Inhibits TMPRSS7. [PubMed: 15853774 Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots]
• Protein Sequence: MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
102	Phosphorylation	APALRHLYKELMGPW HHHHHHHHHHHHCCC	9.04	27251275
172	O-linked_Glycosylation	THTKGMISNLLGKGA HCCHHHHHHHHCCCH	16.72	OGP
193	Phosphorylation	LVLVNALYFNGQWKT HHHHHHHEECCCCCC	7.81	-
200	Phosphorylation	YFNGQWKTPFPDSST EECCCCCCCCCCCCC	27.48	-
215	Phosphorylation	HRRLFHKSDGSTVSV CCEEEECCCCCEEEE	38.34	21406692
218	Phosphorylation	LFHKSDGSTVSVPMM EEECCCCCEEEEEEE	30.53	21406692
219	Phosphorylation	FHKSDGSTVSVPMMA EECCCCCEEEEEEEE	23.48	21406692
221	Phosphorylation	KSDGSTVSVPMMAQT CCCCCEEEEEEEEEC	22.16	21406692
228	Phosphorylation	SVPMMAQTNKFNYTE EEEEEEECCCCCCCE	30.73	21406692
232	N-linked_Glycosylation	MAQTNKFNYTEFTTP EEECCCCCCCEEECC	44.41	UniProtKB CARBOHYD
232	N-linked_Glycosylation	MAQTNKFNYTEFTTP EEECCCCCCCEEECC	44.41	12888867
257	Phosphorylation	PYHGDTLSMFIAAPY CCCCCCEEEEEECCC	17.46	29759185
264	Phosphorylation	SMFIAAPYEKEVPLS EEEEECCCCCCCCHH	34.60	29759185
288	N-linked_Glycosylation	LISHWKGNMTRLPRL HHHHCCCCCCCCCEE	25.56	12888867
288	N-linked_Glycosylation	LISHWKGNMTRLPRL HHHHCCCCCCCCCEE	25.56	12888867
352	N-linked_Glycosylation	QKVKIEVNESGTVAS HCCEEEECCCCCCCC	25.56	UniProtKB CARBOHYD
359	O-linked_Glycosylation	NESGTVASSSTAVIV CCCCCCCCCCEEEEE	22.08	OGP
360	O-linked_Glycosylation	ESGTVASSSTAVIVS CCCCCCCCCEEEEEE	23.21	OGP
362	O-linked_Glycosylation	GTVASSSTAVIVSAR CCCCCCCEEEEEECC	27.22	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAI1_HUMAN	SERPINE1	physical	10731421
TPA_HUMAN	PLAT	physical	2110366
A1AG1_HUMAN	ORM1	physical	11418606
IBP5_HUMAN	IGFBP5	physical	9202242
PSA3_HUMAN	PSMA3	physical	21135093
PSB1_HUMAN	PSMB1	physical	21135093
SGTA_HUMAN	SGTA	physical	25416956
UBQL1_HUMAN	UBQLN1	physical	25416956
SGTB_HUMAN	SGTB	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613329: Plasminogen activator inhibitor-1 deficiency (PAI-1D)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00009: Alteplase
• DB00029: Anistreplase
• DB00055: Drotrecogin alfa
• DB00015: Reteplase
• DB00031: Tenecteplase
• DB00013: Urokinase