SPSB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPSB1_HUMAN
• UniProt AC: Q96BD6
• Protein Name: SPRY domain-containing SOCS box protein 1
• Gene Name: SPSB1
• Organism: Homo sapiens (Human).
• Sequence Length: 273
• Subcellular Localization: Cytoplasm .
• Protein Description: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MGQKVTGGIKT ----CCCCCCCCCEE	35.71	70841
10	Acetylation	QKVTGGIKTVDMRDP CCCCCCCEECCCCCC	45.85	70845
10	Ubiquitination	QKVTGGIKTVDMRDP CCCCCCCEECCCCCC	45.85	21906983
18	Phosphorylation	TVDMRDPTYRPLKQE ECCCCCCCCCCHHHH	36.13	24719451
19	Phosphorylation	VDMRDPTYRPLKQEL CCCCCCCCCCHHHHH	18.67	24719451
31	Phosphorylation	QELQGLDYCKPTRLD HHHCCCCCCCCCCCC	13.86	15601820
68	Ubiquitination	RSLNVFVKEDDKLIF CEEEEEEEECCEEEE	43.92	-
72	Ubiquitination	VFVKEDDKLIFHRHP EEEEECCEEEEECCC	56.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
31	Y	Phosphorylation	Kinase	MET	P08581	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPSB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPSB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOS2_HUMAN	NOS2	physical	21199876
NOS2_HUMAN	NOS2	physical	21549100
NOS2_HUMAN	NOS2	physical	20603330
PAWR_HUMAN	PAWR	physical	20561531
DDX4_HUMAN	DDX4	physical	20561531
DDX4_MOUSE	Ddx4	physical	20561531
PAWR_MOUSE	Pawr	physical	20561531
MET_HUMAN	MET	physical	15713673
RASA1_HUMAN	RASA1	physical	15713673
CUL5_HUMAN	CUL5	physical	15601820
RBX2_HUMAN	RNF7	physical	15601820
ELOB_HUMAN	TCEB2	physical	15601820
ELOC_HUMAN	TCEB1	physical	15601820
KDM1A_HUMAN	KDM1A	physical	23455924
ANM1_HUMAN	PRMT1	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
TGFR2_HUMAN	TGFBR2	physical	26032413
TGFR2_MOUSE	Tgfbr2	physical	26032413

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts withMET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serumresponse element pathway.";
Wang D., Li Z., Messing E.M., Wu G.;
J. Biol. Chem. 280:16393-16401(2005).
Cited for: INTERACTION WITH MET AND RASA1, PHOSPHORYLATION AT TYR-31, ANDMUTAGENESIS OF TYR-31.
PubMed: 15713673