dbPTM

MET_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MET_HUMAN
UniProt AC	P08581
Protein Name	Hepatocyte growth factor receptor
Gene Name	MET
Organism	Homo sapiens (Human).
Sequence Length	1390
Subcellular Localization	Membrane Single-pass type I membrane protein. Isoform 3: Secreted.
Protein Description	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).; Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells..
Protein Sequence	MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	GILVLLFTLVQRSNG HHHHHHHHHHHCCCC	26.45	22210691
22	Phosphorylation	LFTLVQRSNGECKEA HHHHHHCCCCCHHHH	31.90	22210691
45	N-linked_Glycosylation	NMKYQLPNFTAETPI CCCEECCCCCCCCCC	56.33	UniProtKB CARBOHYD
84	Phosphorylation	DLQKVAEYKTGPVLE HHHHHHHHCCCCCCC	12.24	29759185
85	Ubiquitination	LQKVAEYKTGPVLEH HHHHHHHCCCCCCCC	38.21	-
86	Phosphorylation	QKVAEYKTGPVLEHP HHHHHHCCCCCCCCC	45.90	29759185
106	N-linked_Glycosylation	QDCSSKANLSGGVWK CCCCCCCCCCCCCCC	38.18	19196183
149	N-linked_Glycosylation	QRHVFPHNHTADIQS CCCCCCCCCCCCCCC	34.15	UniProtKB CARBOHYD
189	Ubiquitination	AKVLSSVKDRFINFF HHHHHHCHHHHHHHH	45.17	21906983
189 (in isoform 1)	Ubiquitination	-	45.17	21890473
189 (in isoform 2)	Ubiquitination	-	45.17	21890473
202	N-linked_Glycosylation	FFVGNTINSSYFPDH HHCCCCCCCCCCCCC	23.90	UniProtKB CARBOHYD
223	Ubiquitination	VRRLKETKDGFMFLT EEECEECCCCEEEEE	57.87	21906983
223 (in isoform 1)	Ubiquitination	-	57.87	21890473
223 (in isoform 2)	Ubiquitination	-	57.87	21890473
263	Phosphorylation	NNFIYFLTVQRETLD CCEEEEEEEEHHHCC	12.51	24719451
283	Phosphorylation	TRIIRFCSINSGLHS HHHHHHHCCCCCHHH	23.30	29759185
286	Phosphorylation	IRFCSINSGLHSYME HHHHCCCCCHHHHHH	40.85	29759185
290	Phosphorylation	SINSGLHSYMEMPLE CCCCCHHHHHHCCHH	31.08	29759185
291	Phosphorylation	INSGLHSYMEMPLEC CCCCHHHHHHCCHHH	6.07	29759185
324	Ubiquitination	LQAAYVSKPGAQLAR HHHHHCCCHHHHHHH	37.11	21906983
324 (in isoform 1)	Ubiquitination	-	37.11	21890473
324 (in isoform 2)	Ubiquitination	-	37.11	21890473
376	Ubiquitination	YVNDFFNKIVNKNNV HHHHHHHHHHCCCCC	42.76	-
399	N-linked_Glycosylation	PNHEHCFNRTLLRNS CCHHHHHCHHHHHCC	41.23	UniProtKB CARBOHYD
405	N-linked_Glycosylation	FNRTLLRNSSGCEAR HCHHHHHCCCCCHHC	40.26	UniProtKB CARBOHYD
435	Phosphorylation	DLFMGQFSEVLLTSI HHHCCCHHHHHHHHH	20.93	27174698
440	Phosphorylation	QFSEVLLTSISTFIK CHHHHHHHHHHHHHC	21.61	27174698
441	Phosphorylation	FSEVLLTSISTFIKG HHHHHHHHHHHHHCC	17.95	27174698
443	Phosphorylation	EVLLTSISTFIKGDL HHHHHHHHHHHCCCE	19.62	27174698
444	Phosphorylation	VLLTSISTFIKGDLT HHHHHHHHHHCCCEE	27.92	27174698
468	Phosphorylation	RFMQVVVSRSGPSTP EEEEEEEECCCCCCC	14.77	20860994
553	Phosphorylation	VRSEECLSGTWTQQI CCCHHHHCCCCCHHH	45.92	28985074
555	Phosphorylation	SEECLSGTWTQQICL CHHHHCCCCCHHHHH	23.20	28985074
557	Phosphorylation	ECLSGTWTQQICLPA HHHCCCCCHHHHHHH	15.50	28985074
607	N-linked_Glycosylation	KTRVLLGNESCTLTL CCEEEECCCEEEEEE	37.67	UniProtKB CARBOHYD
624	S-palmitoylation	STMNTLKCTVGPAMN HHCHHEEEEECHHHH	4.13	27081699
635	N-linked_Glycosylation	PAMNKHFNMSIIISN HHHHCCCCEEEEEEC	24.02	UniProtKB CARBOHYD
637	Phosphorylation	MNKHFNMSIIISNGH HHCCCCEEEEEECCC	16.25	-
641	Phosphorylation	FNMSIIISNGHGTTQ CCEEEEEECCCCCCC	26.76	-
725	Ubiquitination	TEFAVKLKIDLANRE HHHHEEEEEECCCCC	28.58	-
745	Phosphorylation	YREDPIVYEIHPTKS ECCCCCEEEEECCCC	15.19	20071362
750	Phosphorylation	IVYEIHPTKSFISGG CEEEEECCCCEECCC	25.76	20071362
751	Ubiquitination	VYEIHPTKSFISGGS EEEEECCCCEECCCC	48.06	-
752	Phosphorylation	YEIHPTKSFISGGST EEEECCCCEECCCCE	30.23	23403867
755	Phosphorylation	HPTKSFISGGSTITG ECCCCEECCCCEEEE	34.78	23403867
758	Phosphorylation	KSFISGGSTITGVGK CCEECCCCEEEECCC	21.84	23403867
759	Phosphorylation	SFISGGSTITGVGKN CEECCCCEEEECCCC	26.32	23403867
761	Phosphorylation	ISGGSTITGVGKNLN ECCCCEEEECCCCCC	26.38	23403867
765	Ubiquitination	STITGVGKNLNSVSV CEEEECCCCCCCCCC	56.72	21906983
765 (in isoform 1)	Ubiquitination	-	56.72	21890473
771	Phosphorylation	GKNLNSVSVPRMVIN CCCCCCCCCCEEEEE	26.65	30576142
785	N-linked_Glycosylation	NVHEAGRNFTVACQH EEEHHCCCEEEEEEC	35.70	UniProtKB CARBOHYD
828	Phosphorylation	FMLDGILSKYFDLIY HHHHHHHHHHCEEEE	24.32	20068231
830	Phosphorylation	LDGILSKYFDLIYVH HHHHHHHHCEEEEEC	10.03	23663014
835	Phosphorylation	SKYFDLIYVHNPVFK HHHCEEEEECCCCCC	11.71	23663014
876	Ubiquitination	AVKGEVLKVGNKSCE HHCCCEEEECCCCCC	53.95	-
879	N-linked_Glycosylation	GEVLKVGNKSCENIH CCEEEECCCCCCCEE	35.73	UniProtKB CARBOHYD
894	S-palmitoylation	LHSEAVLCTVPNDLL ECCCEEEEECCHHHH	2.64	27081699
930	N-linked_Glycosylation	VIVQPDQNFTGLIAG EEECCCCCCCHHHHH	43.77	UniProtKB CARBOHYD
959	Ubiquitination	FLWLKKRKQIKDLGS HHHHHHHHHHHHHHH	66.31	-
962	Ubiquitination	LKKRKQIKDLGSELV HHHHHHHHHHHHHHH	44.39	21890473
962	Ubiquitination	LKKRKQIKDLGSELV HHHHHHHHHHHHHHH	44.39	21890473
962	Ubiquitination	LKKRKQIKDLGSELV HHHHHHHHHHHHHHH	44.39	21890473
962 (in isoform 1)	Ubiquitination	-	44.39	21890473
966	Phosphorylation	KQIKDLGSELVRYDA HHHHHHHHHHHHHCC	34.75	28355574
971	Phosphorylation	LGSELVRYDARVHTP HHHHHHHHCCCCCCH	13.38	28152594
977	Phosphorylation	RYDARVHTPHLDRLV HHCCCCCCHHHHHHH	15.00	22167270
977 (in isoform 2)	Ubiquitination	-	15.00	-
980 (in isoform 2)	Ubiquitination	-	4.28	21890473
985	Phosphorylation	PHLDRLVSARSVSPT HHHHHHHHCCCCCCC	23.66	27422710
988	Phosphorylation	DRLVSARSVSPTTEM HHHHHCCCCCCCCCC	27.02	22322096
990	Phosphorylation	LVSARSVSPTTEMVS HHHCCCCCCCCCCCC	20.13	22322096
992	Phosphorylation	SARSVSPTTEMVSNE HCCCCCCCCCCCCCC	28.07	22322096
993	Phosphorylation	ARSVSPTTEMVSNES CCCCCCCCCCCCCCC	26.01	22322096
995 (in isoform 2)	Phosphorylation	-	3.63	27251275
997	Phosphorylation	SPTTEMVSNESVDYR CCCCCCCCCCCCCHH	33.30	28355574
1000	Phosphorylation	TEMVSNESVDYRATF CCCCCCCCCCHHHCC	25.25	23927012
1003	Phosphorylation	VSNESVDYRATFPED CCCCCCCHHHCCCHH	10.45	27273156
1006	Phosphorylation	ESVDYRATFPEDQFP CCCCHHHCCCHHHCC	30.62	23090842
1006 (in isoform 2)	Phosphorylation	-	30.62	27251275
1008 (in isoform 2)	Phosphorylation	-	39.64	27642862
1015	Phosphorylation	PEDQFPNSSQNGSCR CHHHCCCCCCCCCCC	33.27	28555341
1016	Phosphorylation	EDQFPNSSQNGSCRQ HHHCCCCCCCCCCCE	34.01	27050516
1018 (in isoform 2)	Phosphorylation	-	46.42	27642862
1020	Phosphorylation	PNSSQNGSCRQVQYP CCCCCCCCCCEEECC	17.42	27050516
1021 (in isoform 2)	Phosphorylation	-	3.60	27642862
1026	Phosphorylation	GSCRQVQYPLTDMSP CCCCEEECCCCCCCC	11.01	-
1093	Phosphorylation	RGHFGCVYHGTLLDN CCCCEEEEECEEECC	9.90	20736484
1096	Phosphorylation	FGCVYHGTLLDNDGK CEEEEECEEECCCCC	15.73	-
1103	Ubiquitination	TLLDNDGKKIHCAVK EEECCCCCEEEEEEE	51.96	-
1104	Ubiquitination	LLDNDGKKIHCAVKS EECCCCCEEEEEEEC	43.12	-
1110	Acetylation	KKIHCAVKSLNRITD CEEEEEEECCCCCCC	30.60	27452117
1110	Ubiquitination	KKIHCAVKSLNRITD CEEEEEEECCCCCCC	30.60	-
1159	Phosphorylation	SPLVVLPYMKHGDLR CCEEEEEECCCCCHH	18.03	-
1161	Ubiquitination	LVVLPYMKHGDLRNF EEEEEECCCCCHHHH	38.30	21906983
1161 (in isoform 1)	Ubiquitination	-	38.30	21890473
1179	Ubiquitination	ETHNPTVKDLIGFGL CCCCCCHHHHHHHHH	49.66	-
1179 (in isoform 2)	Ubiquitination	-	49.66	21890473
1190	Acetylation	GFGLQVAKGMKYLAS HHHHHHHHHHHHHHC	61.76	7296701
1190	Ubiquitination	GFGLQVAKGMKYLAS HHHHHHHHHHHHHHC	61.76	21906983
1190 (in isoform 1)	Ubiquitination	-	61.76	21890473
1193	Ubiquitination	LQVAKGMKYLASKKF HHHHHHHHHHHCCCC	45.86	-
1194	Phosphorylation	QVAKGMKYLASKKFV HHHHHHHHHHCCCCH	9.90	-
1197 (in isoform 2)	Ubiquitination	-	33.51	-
1199	Ubiquitination	MKYLASKKFVHRDLA HHHHHCCCCHHHHHH	50.56	-
1208 (in isoform 2)	Ubiquitination	-	31.13	21890473
1211 (in isoform 2)	Ubiquitination	-	6.37	-
1215	Ubiquitination	RNCMLDEKFTVKVAD HCCCCCCCEEEEEHH	46.10	-
1219	Ubiquitination	LDEKFTVKVADFGLA CCCCEEEEEHHHCCC	28.75	-
1219 (in isoform 1)	Ubiquitination	-	28.75	21890473
1230	Phosphorylation	FGLARDMYDKEYYSV HCCCCCCCCCCEEEE	28.31	27273156
1232	Ubiquitination	LARDMYDKEYYSVHN CCCCCCCCCEEEECC	30.08	21906983
1232 (in isoform 1)	Ubiquitination	-	30.08	21890473
1233	Phosphorylation	ARDMYDKEYYSVHNK CCCCCCCCEEEECCC	46.97	17016520
1234	Phosphorylation	RDMYDKEYYSVHNKT CCCCCCCEEEECCCC	13.54	21918175
1235	Phosphorylation	DMYDKEYYSVHNKTG CCCCCCEEEECCCCC	12.81	27273156
1236	Phosphorylation	MYDKEYYSVHNKTGA CCCCCEEEECCCCCC	18.92	27273156
1237 (in isoform 2)	Ubiquitination	-	3.14	21890473
1240	Ubiquitination	EYYSVHNKTGAKLPV CEEEECCCCCCCCCC	33.20	2190698
1240 (in isoform 1)	Ubiquitination	-	33.20	21890473
1241	Phosphorylation	YYSVHNKTGAKLPVK EEEECCCCCCCCCCE	47.92	-
1244	Ubiquitination	VHNKTGAKLPVKWMA ECCCCCCCCCCEEHH	55.45	-
1248	Ubiquitination	TGAKLPVKWMALESL CCCCCCCEEHHHHHH	29.34	-
1248 (in isoform 2)	Phosphorylation	-	29.34	27642862
1250 (in isoform 2)	Ubiquitination	-	2.24	21890473
1252 (in isoform 2)	Phosphorylation	-	2.38	27642862
1253 (in isoform 2)	Phosphorylation	-	39.60	27642862
1254 (in isoform 2)	Phosphorylation	-	26.99	27642862
1257	Phosphorylation	MALESLQTQKFTTKS HHHHHHCCCCCCCHH	38.73	29083192
1258 (in isoform 2)	Ubiquitination	-	26.38	21890473
1259	Ubiquitination	LESLQTQKFTTKSDV HHHHCCCCCCCHHHH	48.33	-
1261	Phosphorylation	SLQTQKFTTKSDVWS HHCCCCCCCHHHHHH	40.11	29759185
1262	Phosphorylation	LQTQKFTTKSDVWSF HCCCCCCCHHHHHHH	31.51	29759185
1264	Phosphorylation	TQKFTTKSDVWSFGV CCCCCCHHHHHHHHH	34.99	29759185
1266 (in isoform 2)	Ubiquitination	-	6.27	-
1289	Phosphorylation	PPYPDVNTFDITVYL CCCCCCCCCEEEEEE	23.64	19369195
1295	Phosphorylation	NTFDITVYLLQGRRL CCCEEEEEEECCCCC	7.95	10069803
1307	Phosphorylation	RRLLQPEYCPDPLYE CCCCCCCCCCCCHHH	18.90	22461510
1313	Phosphorylation	EYCPDPLYEVMLKCW CCCCCCHHHHHHHHH	16.33	17062641
1318	Ubiquitination	PLYEVMLKCWHPKAE CHHHHHHHHHCCCHH	19.72	-
1331	Phosphorylation	AEMRPSFSELVSRIS HHHCCCHHHHHHHHH	34.07	7513258
1338	Phosphorylation	SELVSRISAIFSTFI HHHHHHHHHHHHHHC	17.75	7513258
1342	Phosphorylation	SRISAIFSTFIGEHY HHHHHHHHHHCCCCE	19.12	26356563
1343	Phosphorylation	RISAIFSTFIGEHYV HHHHHHHHHCCCCEE	14.44	26356563
1349	Dephosphorylation	STFIGEHYVHVNATY HHHCCCCEEEEEEEE	6.48	12370829
1349	Phosphorylation	STFIGEHYVHVNATY HHHCCCCEEEEEEEE	6.48	22322096
1355	Phosphorylation	HYVHVNATYVNVKCV CEEEEEEEEEEEEEE	23.85	22322096
1356	Dephosphorylation	YVHVNATYVNVKCVA EEEEEEEEEEEEEEC	6.39	12370829
1356	Phosphorylation	YVHVNATYVNVKCVA EEEEEEEEEEEEEEC	6.39	22322096
1365	Phosphorylation	NVKCVAPYPSLLSSE EEEEECCCHHHCCCC	8.84	10417759
1367	Phosphorylation	KCVAPYPSLLSSEDN EEECCCHHHCCCCCC	35.78	28442448
1367 (in isoform 2)	Phosphorylation	-	35.78	27642862
1370	Phosphorylation	APYPSLLSSEDNADD CCCHHHCCCCCCCCC	36.65	19060867
1371	Phosphorylation	PYPSLLSSEDNADDE CCHHHCCCCCCCCCC	49.27	19060867
1373 (in isoform 2)	Phosphorylation	-	58.53	27642862
1374 (in isoform 2)	Phosphorylation	-	41.01	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
985	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
985	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
985	S	Phosphorylation	Kinase	PRKG2	Q13237	GPS
985	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
985	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
985	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
1230	Y	Phosphorylation	Kinase	MET	P08581	PSP
1234	Y	Phosphorylation	Kinase	MST1R	Q04912	GPS
1234	Y	Phosphorylation	Kinase	MET	P08581	PSP
1234	Y	Phosphorylation	Kinase	MET	P97523	PSP
1235	Y	Phosphorylation	Kinase	BMX	P51813	GPS
1235	Y	Phosphorylation	Kinase	MST1R	Q04912	GPS
1235	Y	Phosphorylation	Kinase	MET	P08581	PSP
1235	Y	Phosphorylation	Kinase	MET	P97523	PSP
1349	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
1349	Y	Phosphorylation	Kinase	MST1R	Q04912	GPS
1349	Y	Phosphorylation	Kinase	MET	P08581	PSP
1349	Y	Phosphorylation	Kinase	FER	P16591	PSP
1356	Y	Phosphorylation	Kinase	MET	P08581	PSP
1356	Y	Phosphorylation	Kinase	MST1R	Q04912	GPS
1356	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
1365	Y	Phosphorylation	Kinase	MET	P08581	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	CBL	P22681	PMID:17449471
-	K	Ubiquitination	E3 ubiquitin ligase	RNF126	Q9BV68	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	RNF115	Q9Y4L5	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MET_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MET_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_HUMAN	CTNNB1	physical	11254878
CADH1_HUMAN	CDH1	physical	11254878
HGF_HUMAN	HGF	physical	8380735
RANB9_HUMAN	RANBP9	physical	12147692
GRB2_HUMAN	GRB2	physical	8662889
SHC1_HUMAN	SHC1	physical	9660480
SOS1_HUMAN	SOS1	physical	9660480
GRB2_HUMAN	GRB2	physical	9660480
CBL_HUMAN	CBL	physical	18273061
STAT3_HUMAN	STAT3	physical	9440692
CBL_HUMAN	CBL	physical	16397241
CBL_HUMAN	CBL	physical	19450681
PGS2_HUMAN	DCN	physical	19433454
HGF_HUMAN	HGF	physical	19433454
CBL_HUMAN	CBL	physical	19433454
GRB2_HUMAN	GRB2	physical	19433454
SPSB1_HUMAN	SPSB1	physical	15713673
SPSB2_HUMAN	SPSB2	physical	15713673
SPSB3_HUMAN	SPSB3	physical	15713673
SPSB4_HUMAN	SPSB4	physical	15713673
CBLC_HUMAN	CBLC	physical	22888118
CHIP_HUMAN	STUB1	physical	21325980
HSP74_HUMAN	HSPA4	physical	21325980
HS90A_HUMAN	HSP90AA1	physical	21325980
GLMN_HUMAN	GLMN	physical	11571281
GGA3_HUMAN	GGA3	physical	21664574
GAB1_HUMAN	GAB1	physical	9242692
CBL_HUMAN	CBL	physical	21163258
LRIG1_HUMAN	LRIG1	physical	24828152
CRK_HUMAN	CRK	physical	24828152
SOCS1_HUMAN	SOCS1	physical	25728680
EGFR_HUMAN	EGFR	physical	24362532
ERBB3_HUMAN	ERBB3	physical	21918175
EGFR_HUMAN	EGFR	physical	21918175
MET_HUMAN	MET	physical	23794705
PTEN_HUMAN	PTEN	genetic	28319113
MET_HUMAN	MET	physical	26285778

Drug and Disease Associations

Kegg Disease
H00018	Gastric cancer
H00021	Renal cell carcinoma
H00046	Cholangiocarcinoma
OMIM Disease
	Note=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.
114550
605074	Renal cell carcinoma papillary (RCCP)
Kegg Drug
D09618	Foretinib (USAN/INN)
D09941	Onartuzumab (USAN/INN)
D10173	Tivantinib (USAN/INN)
D10224	Golvatinib (USAN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MET_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Identification of N-glycosylation sites on secreted proteins of humanhepatocellular carcinoma cells with a complementary proteomicsapproach."; Cao J., Shen C., Wang H., Shen H., Chen Y., Nie A., Yan G., Lu H.,Liu Y., Yang P.; J. Proteome Res. 8:662-672(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-106, AND MASSSPECTROMETRY.	19196183 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-966; THR-977; SER-988;SER-990; SER-997; SER-1000; TYR-1003; TYR-1234 AND THR-1289, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-990; SER-997 ANDSER-1000, AND MASS SPECTROMETRY.	18669648 [Abstract]
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"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1234, AND MASSSPECTROMETRY.	19534553 [Abstract]
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"The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growthfactor (HGF)-induced lamellipodium formation, cell scattering and cellspreading."; Koch A., Mancini A., El Bounkari O., Tamura T.; Oncogene 24:3436-3447(2005). Cited for: PHOSPHORYLATION AT TYR-1356, AND INTERACTION WITH INPPL1.	15735664 [Abstract]
"Hepatocyte growth factor receptor tyrosine kinase met is a substrateof the receptor protein-tyrosine phosphatase DEP-1."; Palka H.L., Park M., Tonks N.K.; J. Biol. Chem. 278:5728-5735(2003). Cited for: PHOSPHORYLATION AT TYR-1230; TYR-1234; TYR-1235; TYR-1349 ANDTYR-1365, AND DEPHOSPHORYLATION BY PTPRJ AT TYR-1349 AND TYR-1365.	12475979 [Abstract]
"A multifunctional docking site mediates signaling and transformationby the hepatocyte growth factor/scatter factor receptor family."; Ponzetto C., Bardelli A., Zhen Z., Maina F., dalla Zonca P.,Giordano S., Graziani A., Panayotou G., Comoglio P.M.; Cell 77:261-271(1994). Cited for: AUTOPHOSPHORYLATION AT TYR-1349 AND TYR-1356, AND INTERACTION WITHSRC; PLCG1 AND GRB2.	7513258 [Abstract]
"Identification of the major autophosphorylation site of theMet/hepatocyte growth factor receptor tyrosine kinase."; Ferracini R., Longati P., Naldini L., Vigna E., Comoglio P.M.; J. Biol. Chem. 266:19558-19564(1991). Cited for: PHOSPHORYLATION AT TYR-1235, AND ATP-BINDING SITE LYS-1110.	1655790 [Abstract]