LRIG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRIG1_HUMAN
• UniProt AC: Q96JA1
• Protein Name: Leucine-rich repeats and immunoglobulin-like domains protein 1
• Gene Name: LRIG1 {ECO:0000303|PubMed:15282549}
• Organism: Homo sapiens (Human).
• Sequence Length: 1093
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation..
• Protein Sequence: MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLLLAPKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	DLPSWTRSLNLSYNK CCCHHHHHCCCCCCC	17.77	23403867
74	N-linked_Glycosylation	PSWTRSLNLSYNKLS CHHHHHCCCCCCCCC	28.34	25765764
150	N-linked_Glycosylation	VLDLSLNNITEVRNT HHHHHCCCHHHHHHH	48.10	25765764
177	Phosphorylation	LAGNRIGTLELGAFD CCCCCCEEEECCCCC	18.06	23312004
187	Phosphorylation	LGAFDGLSRSLLTLR CCCCCCCCHHHHHHH	25.92	23312004
236	Phosphorylation	LTFQGLNSLEVLKLQ CEECCCCHHHHHHHH	30.83	-
246	N-linked_Glycosylation	VLKLQRNNISKLTDG HHHHHHCCHHHHCCC	41.94	25765764
259	Phosphorylation	DGAFWGLSKMHVLHL CCCCHHHCCCEEEEE	24.80	-
292	N-linked_Glycosylation	LHQLHLSNNSIARIH HEEHHCCCCCHHHHH	53.26	25765764
318	N-linked_Glycosylation	ELVLSFNNLTRLDEE HHHHCCCCCCCCCHH	40.56	25765764
331	Phosphorylation	EESLAELSSLSVLRL HHHHHHHHCCHHHHC	22.27	-
332	Phosphorylation	ESLAELSSLSVLRLS HHHHHHHCCHHHHCC	36.97	-
334	Phosphorylation	LAELSSLSVLRLSHN HHHHHCCHHHHCCCC	22.51	24719451
594	Phosphorylation	YSHKARLTVNVLPSF CCCEEEEEEEECCCC	12.41	-
600	Phosphorylation	LTVNVLPSFTKTPHD EEEEECCCCCCCCCC	41.19	24719451
602	Phosphorylation	VNVLPSFTKTPHDIT EEECCCCCCCCCCEE	38.04	24670416
603	Ubiquitination	NVLPSFTKTPHDITI EECCCCCCCCCCEEE	59.03	-
623	O-linked_Glycosylation	ARLECAATGHPNPQI EEEHHHHHCCCCCCE	19.94	55832991
634	Ubiquitination	NPQIAWQKDGGTDFP CCCEEEECCCCCCCH	47.87	-
684	N-linked_Glycosylation	SAGSISANATLTVLE CCCEEEECEEEEEEE	27.02	25765764
715	Ubiquitination	ETVALQCKATGNPPP CEEEEEEHHHCCCCC	35.70	-
728	Ubiquitination	PPRITWFKGDRPLSL CCCEEEEECCCCCCC	52.00	-
734	Phosphorylation	FKGDRPLSLTERHHL EECCCCCCCCCCCCC	35.61	26699800
771	Phosphorylation	EMSNTLGTERAHSQL EEECCCCCCCCCCEE	25.97	24719451
833	Phosphorylation	SVTNTDETVVPPDVP CCCCCCCCCCCCCCC	29.61	27282143
844	Phosphorylation	PDVPSYLSSQGTLSD CCCCHHHHCCCCCCC	16.63	27282143
848	Phosphorylation	SYLSSQGTLSDRQET HHHHCCCCCCCCCCE	18.56	27282143
901	Phosphorylation	QPKLCAGSAYHKEPW CCCCCCCCCCCCCHH	13.71	26437602
941	Phosphorylation	CNTEVDCYSRGQAFH CCCEEEEECCCCCCC	9.28	29978859
942	Phosphorylation	NTEVDCYSRGQAFHP CCEEEEECCCCCCCC	35.94	29978859
956	Phosphorylation	PQPVSRDSAQPSAPN CCCCCCCCCCCCCCC	27.91	23312004
960	Phosphorylation	SRDSAQPSAPNGPEP CCCCCCCCCCCCCCC	44.25	23312004
970	Phosphorylation	NGPEPGGSDQEHSPH CCCCCCCCCCCCCCC	41.87	28555341
975	Phosphorylation	GGSDQEHSPHHQCSR CCCCCCCCCCCCCCC	25.77	30177828
981	Phosphorylation	HSPHHQCSRTAAGSC CCCCCCCCCCCCCCC	26.54	30177828
996	Phosphorylation	PECQGSLYPSNHDRM CCCCCCCCCCCCHHC	13.30	-
1029	Phosphorylation	SWTLARLYHPDSTEL CEEEEEECCCCCCCC	13.02	23312004
1033	Phosphorylation	ARLYHPDSTELQPAS EEECCCCCCCCCCCH	28.38	28348404
1034	Phosphorylation	RLYHPDSTELQPASS EECCCCCCCCCCCHH	48.36	24719451
1040	Phosphorylation	STELQPASSLTSGSP CCCCCCCHHCCCCCH	32.34	27251275
1041	Phosphorylation	TELQPASSLTSGSPE CCCCCCHHCCCCCHH	37.46	27251275
1043	Phosphorylation	LQPASSLTSGSPERA CCCCHHCCCCCHHHH	32.75	23312004
1044	Phosphorylation	QPASSLTSGSPERAE CCCHHCCCCCHHHHH	42.43	23312004
1046	Phosphorylation	ASSLTSGSPERAEAQ CHHCCCCCHHHHHCE	24.29	23312004
1054	Phosphorylation	PERAEAQYLLVSNGH HHHHHCEEEEEECCC	14.73	22817900
1069	Phosphorylation	LPKACDASPESTPLT CCCCCCCCCCCCCCC	18.89	22199227
1072	Phosphorylation	ACDASPESTPLTGQL CCCCCCCCCCCCCCC	38.41	30266825
1073	Phosphorylation	CDASPESTPLTGQLP CCCCCCCCCCCCCCC	22.21	30266825
1076	Phosphorylation	SPESTPLTGQLPGKQ CCCCCCCCCCCCCCC	24.88	23403867
1093	Phosphorylation	PLLLAPKS------- CEEECCCC-------	44.38	29214152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CBL	P22681	PMID:15282549

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRIG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRIG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MET_HUMAN	MET	physical	17178829
EGFR_HUMAN	EGFR	physical	15345710
ERBB4_HUMAN	ERBB4	physical	15345710
EGFR_HUMAN	EGFR	physical	15282549
ERBB2_HUMAN	ERBB2	physical	15282549
ERBB3_HUMAN	ERBB3	physical	15282549
ERBB4_HUMAN	ERBB4	physical	15282549
CBL_HUMAN	CBL	physical	15282549
EGFR_HUMAN	EGFR	physical	18542056
UBP8_HUMAN	USP8	physical	24828152
LRIG3_HUMAN	LRIG3	physical	28514442
LRC40_HUMAN	LRRC40	physical	28514442
RAB4A_HUMAN	RAB4A	physical	28514442
CNPY4_HUMAN	CNPY4	physical	28514442
SCRIB_HUMAN	SCRIB	physical	28514442
MFR1L_HUMAN	MTFR1L	physical	28514442
LRIG2_HUMAN	LRIG2	physical	28514442
PON2_HUMAN	PON2	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.