dbPTM

LRC40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LRC40_HUMAN
UniProt AC	Q9H9A6
Protein Name	Leucine-rich repeat-containing protein 40
Gene Name	LRRC40
Organism	Homo sapiens (Human).
Sequence Length	602
Subcellular Localization
Protein Description
Protein Sequence	MSRLKRIAGQDLRAGFKAGGRDCGTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRIPT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Methylation	--MSRLKRIAGQDLR --CCHHHHHHCCCHH	28.69	80701709
13	Methylation	RIAGQDLRAGFKAGG HHHCCCHHHHHHCCC	40.74	80701713
17	Methylation	QDLRAGFKAGGRDCG CCHHHHHHCCCCCCC	45.24	115482321
25	Phosphorylation	AGGRDCGTSVPQGLL CCCCCCCCCCCHHHH	32.65	20068231
26	Phosphorylation	GGRDCGTSVPQGLLK CCCCCCCCCCHHHHH	19.65	20068231
37	Ubiquitination	GLLKAARKSGQLNLS HHHHHHHHHCCCCCC	54.96	21890473
38	Phosphorylation	LLKAARKSGQLNLSG HHHHHHHHCCCCCCC	26.64	20068231
44	Phosphorylation	KSGQLNLSGRNLSEV HHCCCCCCCCCHHHC	34.33	23401153
54	Glutathionylation	NLSEVPQCVWRINVD CHHHCCCEEEEEECC	2.31	22555962
71	Phosphorylation	EEANQNLSFGATERW HHHHCCCCCCCCHHH	29.23	25159151
75	Phosphorylation	QNLSFGATERWWEQT CCCCCCCCHHHHHHC	26.85	27080861
86	Ubiquitination	WEQTDLTKLIISNNK HHHCCHHHHHHCCCC	45.01	21906983
93	Ubiquitination	KLIISNNKLQSLTDD HHHHCCCCHHHHCHH	52.75	21906983
96	Phosphorylation	ISNNKLQSLTDDLRL HCCCCHHHHCHHHHH	43.61	21406692
98	Phosphorylation	NNKLQSLTDDLRLLP CCCHHHHCHHHHHHH	32.49	21406692
108	Phosphorylation	LRLLPALTVLDIHDN HHHHHHEEEEEECCC	22.56	21406692
118	Phosphorylation	DIHDNQLTSLPSAIR EECCCCCCCHHHHHH	20.60	21406692
119	Phosphorylation	IHDNQLTSLPSAIRE ECCCCCCCHHHHHHH	47.04	21406692
122	Phosphorylation	NQLTSLPSAIRELEN CCCCCHHHHHHHHHH	41.44	21406692
132	Acetylation	RELENLQKLNVSHNK HHHHHHHHCCCCCCC	45.24	25953088
132	Ubiquitination	RELENLQKLNVSHNK HHHHHHHHCCCCCCC	45.24	-
139	Ubiquitination	KLNVSHNKLKILPEE HCCCCCCCCCCCHHH	45.81	-
141	Ubiquitination	NVSHNKLKILPEEIT CCCCCCCCCCHHHHH	43.75	-
198	Phosphorylation	ASFSSLSSLVRLNLS CCHHHHHHHHHHCCC	35.86	24719451
210	Ubiquitination	NLSSNELKSLPAEIN CCCCHHHHCCHHHHH	43.71	-
220	Ubiquitination	PAEINRMKRLKHLDC HHHHHHHHHCCCCCC	51.87	-
244	Phosphorylation	PELAGMESLELLYLR HHHCCCCHHHHHHHH	20.46	20860994
249	Phosphorylation	MESLELLYLRRNKLR CCHHHHHHHHHCCCC	15.70	20860994
263	Phosphorylation	RFLPEFPSCSLLKEL CCCCCCCCCHHHHHC	22.97	29759185
264	S-nitrosylation	FLPEFPSCSLLKELH CCCCCCCCHHHHHCC	3.19	19483679
264	S-nitrosocysteine	FLPEFPSCSLLKELH CCCCCCCCHHHHHCC	3.19	-
265	Phosphorylation	LPEFPSCSLLKELHV CCCCCCCHHHHHCCC	40.86	24719451
302	Ubiquitination	DLRDNKLKSVPDEII ECCCCCCCCCCHHHH	51.52	-
303	Phosphorylation	LRDNKLKSVPDEIIL CCCCCCCCCCHHHHH	49.68	-
320	Phosphorylation	SLERLDLSNNDISSL HHHHHCCCCCCCCCC	33.00	21406692
325	Phosphorylation	DLSNNDISSLPYSLG CCCCCCCCCCCCCCC	28.78	21406692
326	Phosphorylation	LSNNDISSLPYSLGN CCCCCCCCCCCCCCC	33.43	21406692
329	Phosphorylation	NDISSLPYSLGNLHL CCCCCCCCCCCCEEE	23.09	21406692
330	Phosphorylation	DISSLPYSLGNLHLK CCCCCCCCCCCEEEE	28.06	21406692
348	Phosphorylation	LEGNPLRTIRREIIS CCCCCHHHHHHHHHC	26.90	-
356	Ubiquitination	IRREIISKGTQEVLK HHHHHHCHHHHHHHH	56.41	-
363	Ubiquitination	KGTQEVLKYLRSKIK HHHHHHHHHHHHHCC	47.62	-
368	Ubiquitination	VLKYLRSKIKDDGPS HHHHHHHHCCCCCCC	47.55	-
370	Ubiquitination	KYLRSKIKDDGPSQS HHHHHHCCCCCCCCC	54.20	-
375	Phosphorylation	KIKDDGPSQSESATE HCCCCCCCCCCCCCC	52.44	23917254
377	Phosphorylation	KDDGPSQSESATETA CCCCCCCCCCCCCCC	37.54	23312004
379	Phosphorylation	DGPSQSESATETAMT CCCCCCCCCCCCCCC	45.82	22817901
381	Phosphorylation	PSQSESATETAMTLP CCCCCCCCCCCCCCC	43.05	29214152
383	Phosphorylation	QSESATETAMTLPSE CCCCCCCCCCCCCCC	19.85	23312004
386	Phosphorylation	SATETAMTLPSESRV CCCCCCCCCCCCCCC	32.81	23186163
389	Phosphorylation	ETAMTLPSESRVNIH CCCCCCCCCCCCEEE	51.85	-
409	Ubiquitination	KILDYSDKQATLIPD EECCCCCCCCEECCH	35.57	-
424	Phosphorylation	EVFDAVKSNIVTSIN HHHHHHHCCCEEEEE	25.78	21406692
428	Phosphorylation	AVKSNIVTSINFSKN HHHCCCEEEEECCHH	21.79	21406692
429	Phosphorylation	VKSNIVTSINFSKNQ HHCCCEEEEECCHHH	12.49	21406692
433	Phosphorylation	IVTSINFSKNQLCEI CEEEEECCHHHCCCC	26.64	21406692
434	Ubiquitination	VTSINFSKNQLCEIP EEEEECCHHHCCCCC	44.57	-
442	Ubiquitination	NQLCEIPKRMVELKE HHCCCCCHHHHHHHH	59.80	-
452	Phosphorylation	VELKEMVSDVDLSFN HHHHHHHHCCCCCCC	30.52	21406692
457	Phosphorylation	MVSDVDLSFNKLSFI HHHCCCCCCCHHHHH	23.47	21406692
475	Phosphorylation	LCVLQKLTFLDLRNN HHHHHHCHHHHHHHH	29.23	21406692
499	Phosphorylation	ESLVRLQTINLSFNR HHHHHHHHCCCCCCH	19.20	21406692
503	Phosphorylation	RLQTINLSFNRFKML HHHHCCCCCCHHHCH	18.91	21406692
569	Phosphorylation	GNCVNLRTLLLDGNP CCCEEHHHEEECCCC	25.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LRC40_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LRC40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LRC40_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MTNA_HUMAN	MRI1	physical	22939629
PGK2_HUMAN	PGK2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LRC40_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, AND MASSSPECTROMETRY.	18669648 [Abstract]