RAB4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB4A_HUMAN
• UniProt AC: P20338
• Protein Name: Ras-related protein Rab-4A
• Gene Name: RAB4A
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Membrane; Peripheral membrane protein . Cytoplasm . Early endosome membrane ; Peripheral membrane protein . Recycling endosome membrane ; Peripheral membrane protein . Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.
• Protein Description: Protein transport. Probably involved in vesicular traffic (By similarity)..
• Protein Sequence: MSQTAMSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFVQCARKILNKIESGELDPERMGSGIQYGDAALRQLRSPRRAQAPNAQECGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQTAMSET ------CCCCHHHHH	38.35	23663014
4	Phosphorylation	----MSQTAMSETYD ----CCCCHHHHHHH	22.53	23663014
7	Phosphorylation	-MSQTAMSETYDFLF -CCCCHHHHHHHHHH	6.43	23663014
9	Phosphorylation	SQTAMSETYDFLFKF CCCHHHHHHHHHHEE	5.48	23663014
10	Phosphorylation	QTAMSETYDFLFKFL CCHHHHHHHHHHEEE	39.68	23663014
24	Phosphorylation	LVIGNAGTGKSCLLH EEECCCCCCHHHHHH	6.54	23663014
42	Phosphorylation	EKKFKDDSNHTIGVE HHHCCCCCCCEEEEE	17.66	27251275
45	Phosphorylation	FKDDSNHTIGVEFGS CCCCCCCEEEEEECC	14.39	26471730
63	Ubiquitination	NVGGKYVKLQIWDTA EECCEEEEEEEEECC	28.45	-
69	Phosphorylation	VKLQIWDTAGQERFR EEEEEEECCCHHHHH	25.13	28857561
72	Serotonylation	QIWDTAGQERFRSVT EEEECCCHHHHHHHH	25.73	-
137	Phosphorylation	LDADREVTFLEASRF CCCCHHHHHHHHHHH	20.68	-
142	Phosphorylation	EVTFLEASRFAQENE HHHHHHHHHHHHHCC	49.60	-
190	Phosphorylation	LDPERMGSGIQYGDA CCHHHCCCCCCHHHH	11.16	21945579
194	Phosphorylation	RMGSGIQYGDAALRQ HCCCCCCHHHHHHHH	3.72	26657352
199	Phosphorylation	IQYGDAALRQLRSPR CCHHHHHHHHCCCCC	31.20	1425574
204	Phosphorylation	AALRQLRSPRRAQAP HHHHHCCCCCHHCCC	56.38	1425574
216	Geranylgeranylation	QAPNAQECGC----- CCCCHHHCCC-----		-
218	Methylation	PNAQECGC------- CCHHHCCC-------		-
218	Geranylgeranylation	PNAQECGC------- CCHHHCCC-------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
199	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
199	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
204	S	Phosphorylation	Kinase	CDK1	P06493	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB4A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF3B_HUMAN	KIF3B	physical	12832475
P53_HUMAN	TP53	physical	16169070
RABE1_HUMAN	RABEP1	physical	9524117
RAB5A_HUMAN	RAB5A	physical	9524117
STX4_HUMAN	STX4	physical	11063739
PIN1_HUMAN	PIN1	physical	10888662
RAB4A_BOVIN	RAB4A	physical	11788822
RABE2_BOVIN	RABEP2	physical	11788822
RFIP1_HUMAN	RAB11FIP1	physical	11786538
DC1L1_HUMAN	DYNC1LI1	physical	11243854
HACE1_HUMAN	HACE1	physical	21988917
HACE1_BOVIN	HACE1	physical	21988917
RABE1_HUMAN	RABEP1	physical	10720461
KCNA5_HUMAN	KCNA5	physical	18755741
RUFY1_HUMAN	RUFY1	physical	14617813
RUFY1_HUMAN	RUFY1	physical	20534812
RBGP1_HUMAN	RABGAP1	physical	21988832
RABE2_HUMAN	RABEP2	physical	21988832
ZN830_HUMAN	ZNF830	physical	21988832
VPS52_HUMAN	VPS52	physical	25416956
EXOC5_HUMAN	EXOC5	physical	25416956
RABE1_HUMAN	RABEP1	physical	26430212

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.