KIF3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF3B_HUMAN
• UniProt AC: O15066
• Protein Name: Kinesin-like protein KIF3B
• Gene Name: KIF3B
• Organism: Homo sapiens (Human).
• Sequence Length: 747
• Subcellular Localization: Cytoplasm, cytoskeleton . Cell projection, cilium .
• Protein Description: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity)..
• Protein Sequence: MSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLEEKSKIMNRAFFDEEEDHWKLHPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEARYRAENIVLLELDMPSRTTRDYEGPAIAPKVQAALDAALQDEDEIQVDASSFESTANKKSKARPKSGRKSGSSSSSSGTPASQLYPQSRGLVPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MSKLKSSE -------CCCCCCCC	7.81	22814378
2	Acetylation	------MSKLKSSES ------CCCCCCCCC	46.85	22814378
2	Phosphorylation	------MSKLKSSES ------CCCCCCCCC	46.85	30177828
6	Phosphorylation	--MSKLKSSESVRVV --CCCCCCCCCEEEE	50.18	30177828
7	Phosphorylation	-MSKLKSSESVRVVV -CCCCCCCCCEEEEE	32.10	30177828
9	Phosphorylation	SKLKSSESVRVVVRC CCCCCCCCEEEEEEE	19.71	30177828
30	Acetylation	EKAASYDKVVDVDVK HHCCCCCEEEEEEEE	35.61	26051181
49	Phosphorylation	SVKNPKGTAHEMPKT EEECCCCCCCCCCCE	30.85	-
53	Sulfoxidation	PKGTAHEMPKTFTFD CCCCCCCCCCEEEEE	2.71	30846556
58	Phosphorylation	HEMPKTFTFDAVYDW CCCCCEEEEEEEEEC	26.32	-
122	Phosphorylation	KRGVIPNSFDHIFTH HCCCCCCCHHHHHHH	27.05	-
157	Phosphorylation	EEIRDLLSKDQTKRL HHHHHHHCCCHHHCC	41.29	21060948
162	Methylation	LLSKDQTKRLELKER HHCCCHHHCCCCCCC	49.72	-
167	Methylation	QTKRLELKERPDTGV HHHCCCCCCCCCCCE	42.15	-
180	Phosphorylation	GVYVKDLSSFVTKSV CEEEECHHHHHHHHH	31.68	28857561
181	Phosphorylation	VYVKDLSSFVTKSVK EEEECHHHHHHHHHH	30.91	28857561
184	Phosphorylation	KDLSSFVTKSVKEIE ECHHHHHHHHHHHHH	18.65	23312004
202	Phosphorylation	NVGNQNRSVGATNMN CCCCCCCCCCCCCCC	32.24	22210691
206	Phosphorylation	QNRSVGATNMNEHSS CCCCCCCCCCCCCCC	29.13	22210691
212	Phosphorylation	ATNMNEHSSRSHAIF CCCCCCCCCCCCEEE	22.67	22210691
213	Phosphorylation	TNMNEHSSRSHAIFV CCCCCCCCCCCEEEE	39.44	22210691
240	Ubiquitination	ENHIRVGKLNLVDLA CCCEEEEECEEEECC	31.20	24816145
298	Phosphorylation	PYRDSKLTRLLQDSL CCCCHHHHHHHHHHC	24.02	20068231
304	Phosphorylation	LTRLLQDSLGGNAKT HHHHHHHHCCCCCEE	18.89	28176443
351	Ubiquitination	PRVNEDPKDALLREF CCCCCCHHHHHHHHH	68.87	24816145
410	Acetylation	GEEEGDDKDDYWREQ CCCCCCCHHHHHHHH	58.18	26051181
457	Ubiquitination	MEDLRREKDAAEMLG HHHHHHHHHHHHHHH	51.35	29967540
473	Malonylation	KIKAMESKLLVGGKN HHHHHHHHEEECCCC	32.31	32601280
473	Acetylation	KIKAMESKLLVGGKN HHHHHHHHEEECCCC	32.31	25953088
546	Phosphorylation	KKLKKLFSKLQAVKA HHHHHHHHHHHHHHH	42.78	24719451
631	Phosphorylation	QMMKRPVSAVGYKRP HHHCCCCCCCCCCCC	21.66	24719451
635	Phosphorylation	RPVSAVGYKRPLSQH CCCCCCCCCCCCCHH	9.38	24719451
640	Phosphorylation	VGYKRPLSQHARMSM CCCCCCCCHHCHHHH	23.70	24719451
646	Phosphorylation	LSQHARMSMMIRPEA CCHHCHHHHHHCHHH	10.31	28555341
669	Phosphorylation	LLELDMPSRTTRDYE EEEEECCCCCCCCCC	35.30	22210691
671	Phosphorylation	ELDMPSRTTRDYEGP EEECCCCCCCCCCCC	30.44	21945579
672	Phosphorylation	LDMPSRTTRDYEGPA EECCCCCCCCCCCCC	22.04	21945579
675	Phosphorylation	PSRTTRDYEGPAIAP CCCCCCCCCCCCHHH	21.35	21945579
714	Acetylation	STANKKSKARPKSGR HHCCCCCCCCCCCCC	58.24	7678513
723	Phosphorylation	RPKSGRKSGSSSSSS CCCCCCCCCCCCCCC	42.41	25159151
725	Phosphorylation	KSGRKSGSSSSSSGT CCCCCCCCCCCCCCC	33.85	28387310
726	Phosphorylation	SGRKSGSSSSSSGTP CCCCCCCCCCCCCCC	37.45	22199227
727	Phosphorylation	GRKSGSSSSSSGTPA CCCCCCCCCCCCCCH	35.62	25159151
728	Phosphorylation	RKSGSSSSSSGTPAS CCCCCCCCCCCCCHH	30.39	22199227
729	Phosphorylation	KSGSSSSSSGTPASQ CCCCCCCCCCCCHHH	34.43	22199227
730	Phosphorylation	SGSSSSSSGTPASQL CCCCCCCCCCCHHHC	48.94	22199227
732	Phosphorylation	SSSSSSGTPASQLYP CCCCCCCCCHHHCCC	20.03	22199227
735	Phosphorylation	SSSGTPASQLYPQSR CCCCCCHHHCCCCCC	23.17	27251275
738	Phosphorylation	GTPASQLYPQSRGLV CCCHHHCCCCCCCCC	7.50	-
741	Phosphorylation	ASQLYPQSRGLVPK- HHHCCCCCCCCCCC-	24.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIF3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RBTN2_HUMAN	LMO2	physical	21988832
KIF3A_HUMAN	KIF3A	physical	27173435
KIF3C_HUMAN	KIF3C	physical	27173435
NHRF2_HUMAN	SLC9A3R2	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.