KIF3C_HUMAN - dbPTM
KIF3C_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIF3C_HUMAN
UniProt AC O14782
Protein Name Kinesin-like protein KIF3C
Gene Name KIF3C
Organism Homo sapiens (Human).
Sequence Length 793
Subcellular Localization Cytoplasm, cytoskeleton .
Protein Description Microtubule-based anterograde translocator for membranous organelles..
Protein Sequence MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPQVNEDPKDTLLREFQEEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILESALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRLFLDCEEEQWKFQPLVPAGVSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELDVSPPAVFEMEFSHDQEQDPRALHMERLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPSTTHASLASASLRPATVADHE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MASKTKASEALK
---CCCCHHHHHHHH		29.37-
8PhosphorylationMASKTKASEALKVVA
CCCCHHHHHHHHHHH		25.5926270265
163MethylationLLSKEPGKRLELKEN
HHCCCCCCCCCCCCC		65.61-
168MethylationPGKRLELKENPETGV
CCCCCCCCCCCCCCE		46.1830589731
168AcetylationPGKRLELKENPETGV
CCCCCCCCCCCCCCE		46.1830589731
173PhosphorylationELKENPETGVYIKDL
CCCCCCCCCEEEECH		32.9523312004
176PhosphorylationENPETGVYIKDLSSF
CCCCCCEEEECHHHH		12.0023312004
178AcetylationPETGVYIKDLSSFVT
CCCCEEEECHHHHHH		34.6219820829
178UbiquitinationPETGVYIKDLSSFVT
CCCCEEEECHHHHHH		34.62-
181PhosphorylationGVYIKDLSSFVTKNV
CEEEECHHHHHHCCH		31.6828857561
182PhosphorylationVYIKDLSSFVTKNVK
EEEECHHHHHHCCHH		30.9128857561
185PhosphorylationKDLSSFVTKNVKEIE
ECHHHHHHCCHHHHH		18.1923312004
213PhosphorylationSTHMNEVSSRSHAIF
CCCCCCHHCCCEEEE		17.5430257219
214PhosphorylationTHMNEVSSRSHAIFI
CCCCCHHCCCEEEEE		42.8730257219
260PhosphorylationQNKAGPNTAGGAATP
CCCCCCCCCCCCCCC		29.7928961369
268PhosphorylationAGGAATPSSGGGGGG
CCCCCCCCCCCCCCC		36.9428857561
269PhosphorylationGGAATPSSGGGGGGG
CCCCCCCCCCCCCCC		42.5322210691
278PhosphorylationGGGGGGGSGGGAGGE
CCCCCCCCCCCCCCC		37.2222210691
291PhosphorylationGERPKEASKINLSLS
CCCCCHHHHCCCHHH		34.8528857561
312PhosphorylationAALAGNRSTHIPYRD
HHHCCCCCCCCCCCH		28.47-
317PhosphorylationNRSTHIPYRDSKLTR
CCCCCCCCCHHHHHH		26.84-
323PhosphorylationPYRDSKLTRLLQDSL
CCCHHHHHHHHHHHC		24.0220068231
329PhosphorylationLTRLLQDSLGGNAKT
HHHHHHHHCCCCCEE		18.8928176443
341PhosphorylationAKTIMVATLGPASHS
CEEEEEEEECCCCCC		22.34-
465UbiquitinationENYLQEQKERLEEEK
HHHHHHHHHHHHHHH		44.01-
488UbiquitinationLVSEEKQKLLEEKEK
HHHHHHHHHHHHHHH		67.1321890473
493UbiquitinationKQKLLEEKEKMLEDL
HHHHHHHHHHHHHHH		53.9421890473
513UbiquitinationATELLAAKYKAMESK
HHHHHHHHHHHHHHC		41.50-
532PhosphorylationGRNIMDHTNEQQKML
CCCCCCCCHHHHHHH		35.8730622161
574PhosphorylationTMELRGTYTSLQQEV
HHHHHCCCHHHHHHH		9.35-
585PhosphorylationQQEVEVKTKKLKKLY
HHHHHHCHHHHHHHH		38.2917924679
670PhosphorylationPLVPAGVSSSQMKKR
CCCCCCCCHHHCCCC		24.2925690035
671PhosphorylationLVPAGVSSSQMKKRP
CCCCCCCHHHCCCCC		23.3728555341
679PhosphorylationSQMKKRPTSAVGYKR
HHCCCCCCCCCCCCC		33.0927732954
680PhosphorylationQMKKRPTSAVGYKRP
HCCCCCCCCCCCCCC		24.5227732954
684PhosphorylationRPTSAVGYKRPISQY
CCCCCCCCCCCHHHH		9.38-
747PhosphorylationERLMRLDSFLERPST
HHHHCHHHHHHCCCC		36.0028857561
753PhosphorylationDSFLERPSTSKVRKS
HHHHHCCCCHHHHHC		52.0821060948
754PhosphorylationSFLERPSTSKVRKSR
HHHHCCCCHHHHHCC		34.9421060948
755PhosphorylationFLERPSTSKVRKSRS
HHHCCCCHHHHHCCC		33.2321060948
762PhosphorylationSKVRKSRSWCQSPQR
HHHHHCCCCCCCCCC		39.0223312004
766PhosphorylationKSRSWCQSPQRPPPS
HCCCCCCCCCCCCCC		21.6223312004
773PhosphorylationSPQRPPPSTTHASLA
CCCCCCCCCCCHHHH		52.2723312004
774PhosphorylationPQRPPPSTTHASLAS
CCCCCCCCCCHHHHH		28.5123312004
775PhosphorylationQRPPPSTTHASLASA
CCCCCCCCCHHHHHH		21.5623312004
778PhosphorylationPPSTTHASLASASLR
CCCCCCHHHHHHCCC		19.5023312004
781PhosphorylationTTHASLASASLRPAT
CCCHHHHHHCCCCCC		24.5523312004
783PhosphorylationHASLASASLRPATVA
CHHHHHHCCCCCCCC		23.5523312004
788PhosphorylationSASLRPATVADHE--
HHCCCCCCCCCCC--		20.9323312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KIF3C_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIF3C_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIF3C_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KIF3A_HUMANKIF3Aphysical
26496610
KIFA3_HUMANKIFAP3physical
26496610
ZC3H3_HUMANZC3H3physical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIF3C_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-585, AND MASSSPECTROMETRY.

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