| UniProt ID | ZC3H3_HUMAN | |
|---|---|---|
| UniProt AC | Q8IXZ2 | |
| Protein Name | Zinc finger CCCH domain-containing protein 3 | |
| Gene Name | ZC3H3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 948 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Required for the export of polyadenylated mRNAs from the nucleus. [PubMed: 19364924 Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity] | |
| Protein Sequence | MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRRGYSSHHGPSWRKKYSLVNRPPGPSDPPADHAVRPLHGARGGQPPVPQQHVLERQVQLSQGQNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRARGTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTGVALGRKLGSHSVASCAPQLLGDRRVDAGHTDQPVPSGSVGGPARPASGPRQAREASLVVTCRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPKPRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRPAVGHSGLKPLSGETPLSAYKVKSRTKIIRRRSSTSLPGDKKSGTSPAATAKSHLSLRRRQALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRYRIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRPLLRTGRLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHHVSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKCKKKHTLLCPDFARRGACPRGAQCQLLHRTQKRHSRRAATSPAPGPSDATARSRVSASHGPRKPSASQRPTRQTPSSAALTAAAVAAPPHCPGGSASPSSSKASSSSSSSSSPPASLDHEAPSLQEAALAAACSNRLCKLPSFISLQSSPSPGAQPRVRAPRAPLTKDSGKPLHIKPRL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 (in isoform 2) | Phosphorylation | - | 33.83 | 30631047 | |
| 13 (in isoform 2) | Phosphorylation | - | 4.47 | 30631047 | |
| 60 | Methylation | RYPRPSRRGYSSHHG CCCCCCCCCCCCCCC | 53.38 | 115920329 | |
| 63 | Phosphorylation | RPSRRGYSSHHGPSW CCCCCCCCCCCCCCH | 26.48 | - | |
| 69 | Phosphorylation | YSSHHGPSWRKKYSL CCCCCCCCHHHHCCC | 44.07 | 26091039 | |
| 73 | Ubiquitination | HGPSWRKKYSLVNRP CCCCHHHHCCCCCCC | 31.34 | 29967540 | |
| 132 | Ubiquitination | IKVKPPSKSGSASAS EEEECCCCCCCCCCC | 65.69 | 29967540 | |
| 145 | Phosphorylation | ASGAQRGSLEEFEET CCCCCCCCHHHHHCC | 34.49 | 28985074 | |
| 174 | Phosphorylation | PRGQLQPSRPTRARG CCCCCCCCCCCCCCC | 37.62 | - | |
| 204 | Phosphorylation | GKPRMVKSVGSVGDS CCCCEEEECCCCCCC | 21.94 | 20068231 | |
| 207 | Phosphorylation | RMVKSVGSVGDSPRE CEEEECCCCCCCCCC | 22.29 | 25850435 | |
| 211 | Phosphorylation | SVGSVGDSPREPRRT ECCCCCCCCCCCCCC | 21.67 | 25159151 | |
| 218 | Phosphorylation | SPREPRRTVSESVIA CCCCCCCCCCHHEEE | 29.66 | 28122231 | |
| 220 | Phosphorylation | REPRRTVSESVIAVK CCCCCCCCHHEEEEE | 24.44 | 28122231 | |
| 222 | Phosphorylation | PRRTVSESVIAVKAS CCCCCCHHEEEEEEC | 16.00 | 29978859 | |
| 232 | Phosphorylation | AVKASFPSSALPPRT EEEECCCCCCCCCCC | 26.66 | 21857030 | |
| 233 | Phosphorylation | VKASFPSSALPPRTG EEECCCCCCCCCCCC | 33.78 | 21857030 | |
| 287 | Phosphorylation | GGPARPASGPRQARE CCCCCCCCCCCHHCE | 52.60 | 28555341 | |
| 303 | Phosphorylation | SLVVTCRTNKFRKNN EEEEEECCCCCCCCC | 44.93 | 18491316 | |
| 317 | Phosphorylation | NYKWVAASSKSPRVA CCEEEEECCCCHHHH | 28.67 | 28348404 | |
| 318 | Phosphorylation | YKWVAASSKSPRVAR CEEEEECCCCHHHHH | 32.21 | 28348404 | |
| 320 | Phosphorylation | WVAASSKSPRVARRA EEEECCCCHHHHHHH | 21.64 | 30624053 | |
| 329 | Phosphorylation | RVARRALSPRVAAEN HHHHHHCCHHHHHHH | 15.07 | 24719451 | |
| 350 | Ubiquitination | GMANKVEKPQLIADP CCCCCCCCCCCCCCC | 40.84 | 29967540 | |
| 377 | Phosphorylation | PGSAPSKYKWKASSP CCCCCCCCEEEECCC | 26.81 | 29396449 | |
| 382 | Phosphorylation | SKYKWKASSPSASSS CCCEEEECCCCCCCC | 38.77 | 28450419 | |
| 383 | Phosphorylation | KYKWKASSPSASSSS CCEEEECCCCCCCCC | 27.94 | 25159151 | |
| 385 | Phosphorylation | KWKASSPSASSSSSF EEEECCCCCCCCCCC | 42.61 | 29396449 | |
| 387 | Phosphorylation | KASSPSASSSSSFRW EECCCCCCCCCCCCC | 34.78 | 29396449 | |
| 388 | Phosphorylation | ASSPSASSSSSFRWQ ECCCCCCCCCCCCCC | 33.68 | 29396449 | |
| 389 | Phosphorylation | SSPSASSSSSFRWQS CCCCCCCCCCCCCCC | 27.75 | 29396449 | |
| 390 | Phosphorylation | SPSASSSSSFRWQSE CCCCCCCCCCCCCCC | 35.13 | 29396449 | |
| 391 | Phosphorylation | PSASSSSSFRWQSEA CCCCCCCCCCCCCCC | 22.30 | 29396449 | |
| 405 | Phosphorylation | ASSKDHASQLSPVLS CCCCCCHHHHHHHHH | 28.38 | 20363803 | |
| 408 | Phosphorylation | KDHASQLSPVLSRSP CCCHHHHHHHHHCCC | 12.82 | 23401153 | |
| 412 | Phosphorylation | SQLSPVLSRSPSGDR HHHHHHHHCCCCCCC | 30.83 | 25159151 | |
| 414 | Phosphorylation | LSPVLSRSPSGDRPA HHHHHHCCCCCCCCC | 21.75 | 25159151 | |
| 416 | Phosphorylation | PVLSRSPSGDRPAVG HHHHCCCCCCCCCCC | 55.35 | 26657352 | |
| 425 | Phosphorylation | DRPAVGHSGLKPLSG CCCCCCCCCCCCCCC | 39.63 | 21406692 | |
| 428 | Ubiquitination | AVGHSGLKPLSGETP CCCCCCCCCCCCCCC | 47.65 | 29967540 | |
| 434 | Phosphorylation | LKPLSGETPLSAYKV CCCCCCCCCCCEEEC | 32.81 | 27050516 | |
| 437 | Phosphorylation | LSGETPLSAYKVKSR CCCCCCCCEEECCCC | 30.65 | 25159151 | |
| 452 | Phosphorylation | TKIIRRRSSTSLPGD CEEEECCCCCCCCCC | 35.84 | - | |
| 453 | Phosphorylation | KIIRRRSSTSLPGDK EEEECCCCCCCCCCC | 21.87 | - | |
| 454 | Phosphorylation | IIRRRSSTSLPGDKK EEECCCCCCCCCCCC | 35.21 | - | |
| 460 | Acetylation | STSLPGDKKSGTSPA CCCCCCCCCCCCCHH | 55.54 | 20167786 | |
| 462 | Phosphorylation | SLPGDKKSGTSPAAT CCCCCCCCCCCHHHH | 53.71 | 26657352 | |
| 464 | Phosphorylation | PGDKKSGTSPAATAK CCCCCCCCCHHHHHH | 38.33 | 22210691 | |
| 465 | Phosphorylation | GDKKSGTSPAATAKS CCCCCCCCHHHHHHH | 18.96 | 24850871 | |
| 472 | Phosphorylation | SPAATAKSHLSLRRR CHHHHHHHHHHHHHH | 27.48 | 22210691 | |
| 475 | Phosphorylation | ATAKSHLSLRRRQAL HHHHHHHHHHHHHHH | 17.88 | 24719451 | |
| 486 | Phosphorylation | RQALRGKSSPVLKKT HHHHCCCCCCCHHCC | 42.57 | 26471730 | |
| 487 | Phosphorylation | QALRGKSSPVLKKTP HHHCCCCCCCHHCCC | 23.63 | 20860994 | |
| 519 | Ubiquitination | SRAHLPTKEASSLHA CCCCCCCCCCCCCCE | 49.71 | 29967540 | |
| 522 | Phosphorylation | HLPTKEASSLHAVRT CCCCCCCCCCCEECC | 34.23 | 20860994 | |
| 523 | Phosphorylation | LPTKEASSLHAVRTA CCCCCCCCCCEECCC | 31.08 | 20860994 | |
| 534 | Ubiquitination | VRTAPTSKVIKTRYR ECCCCCCCCEEEEEE | 50.92 | 29967540 | |
| 546 | Phosphorylation | RYRIVKKTPASPLSA EEEEEECCCCCCCCC | 20.54 | 28122231 | |
| 549 | Phosphorylation | IVKKTPASPLSAPPF EEECCCCCCCCCCCC | 27.81 | 28122231 | |
| 552 | Phosphorylation | KTPASPLSAPPFPLS CCCCCCCCCCCCCCC | 41.96 | 28122231 | |
| 562 | Phosphorylation | PFPLSLPSWRARRLS CCCCCCCHHHHHHHH | 34.19 | 26091039 | |
| 569 | Phosphorylation | SWRARRLSLSRSLVL HHHHHHHHHCHHHHH | 23.61 | 23927012 | |
| 571 | Phosphorylation | RARRLSLSRSLVLNR HHHHHHHCHHHHHHH | 19.22 | 17192257 | |
| 584 | Phosphorylation | NRLRPVASGGGKAQP HHCCCCCCCCCCCCC | 37.90 | 21406692 | |
| 593 | Phosphorylation | GGKAQPGSPWWRSKG CCCCCCCCCCHHHCC | 24.83 | 25159151 | |
| 609 | Phosphorylation | RCIGGVLYKVSANKL EEECCEEEEEEHHHC | 13.62 | 22817900 | |
| 617 | Phosphorylation | KVSANKLSKTSGQPS EEEHHHCCCCCCCCC | 35.18 | 22817900 | |
| 634 | Phosphorylation | GSRPLLRTGRLDPAG CCCCCCCCCCCCCCC | 26.99 | 22468782 | |
| 642 | Phosphorylation | GRLDPAGSCSRSLAS CCCCCCCCCCHHHHH | 15.83 | 22468782 | |
| 644 | Phosphorylation | LDPAGSCSRSLASRA CCCCCCCCHHHHHHH | 26.97 | 24425749 | |
| 707 | O-linked_Glycosylation | CTRFVRGTCKKTDGT EEHHHHCCCCCCCCC | 15.58 | 30379171 | |
| 723 | Ubiquitination | PFSHHVSKEKMPVCS CCCCCCCCCCCCCHH | 61.33 | 29967540 | |
| 744 | Phosphorylation | CSNSNCPYSHVYVSR HCCCCCCCCEEEECC | 17.38 | 29496907 | |
| 748 | Phosphorylation | NCPYSHVYVSRKAEV CCCCCEEEECCCHHH | 6.31 | 29496907 | |
| 775 | Phosphorylation | AKCKKKHTLLCPDFA HHHCCCCEEECCHHH | 30.24 | 25002506 | |
| 809 | Phosphorylation | RHSRRAATSPAPGPS HHHHHCCCCCCCCCC | 33.97 | 30266825 | |
| 810 | Phosphorylation | HSRRAATSPAPGPSD HHHHCCCCCCCCCCC | 17.84 | 30266825 | |
| 821 | Dimethylation | GPSDATARSRVSASH CCCCHHHHHHHHHCC | 22.20 | - | |
| 821 | Methylation | GPSDATARSRVSASH CCCCHHHHHHHHHCC | 22.20 | 115390763 | |
| 834 | Phosphorylation | SHGPRKPSASQRPTR CCCCCCCCHHHCCCC | 43.52 | 20363803 | |
| 836 | Phosphorylation | GPRKPSASQRPTRQT CCCCCCHHHCCCCCC | 30.93 | 20363803 | |
| 843 | Phosphorylation | SQRPTRQTPSSAALT HHCCCCCCCCHHHHH | 23.11 | 23312004 | |
| 845 | Phosphorylation | RPTRQTPSSAALTAA CCCCCCCCHHHHHHH | 35.68 | 23312004 | |
| 846 | Phosphorylation | PTRQTPSSAALTAAA CCCCCCCHHHHHHHH | 20.82 | 23312004 | |
| 850 | Phosphorylation | TPSSAALTAAAVAAP CCCHHHHHHHHHHCC | 14.99 | 23312004 | |
| 864 | Phosphorylation | PPHCPGGSASPSSSK CCCCCCCCCCCCCCC | 31.33 | 30576142 | |
| 866 | Phosphorylation | HCPGGSASPSSSKAS CCCCCCCCCCCCCCC | 27.32 | 30576142 | |
| 868 | Phosphorylation | PGGSASPSSSKASSS CCCCCCCCCCCCCCC | 44.76 | 29978859 | |
| 869 | Phosphorylation | GGSASPSSSKASSSS CCCCCCCCCCCCCCC | 38.96 | 29978859 | |
| 870 | Phosphorylation | GSASPSSSKASSSSS CCCCCCCCCCCCCCC | 36.26 | 29978859 | |
| 873 | Phosphorylation | SPSSSKASSSSSSSS CCCCCCCCCCCCCCC | 34.19 | 25627689 | |
| 875 | Phosphorylation | SSSKASSSSSSSSSP CCCCCCCCCCCCCCC | 31.57 | 25159151 | |
| 876 | Phosphorylation | SSKASSSSSSSSSPP CCCCCCCCCCCCCCC | 35.87 | 27080861 | |
| 877 | Phosphorylation | SKASSSSSSSSSPPA CCCCCCCCCCCCCCC | 35.87 | 27080861 | |
| 878 | Phosphorylation | KASSSSSSSSSPPAS CCCCCCCCCCCCCCC | 35.87 | 27080861 | |
| 879 | Phosphorylation | ASSSSSSSSSPPASL CCCCCCCCCCCCCCC | 36.46 | 27080861 | |
| 885 | Phosphorylation | SSSSPPASLDHEAPS CCCCCCCCCCCCCCC | 39.85 | 27080861 | |
| 914 | Phosphorylation | CKLPSFISLQSSPSP HCCCCCEECCCCCCC | 20.53 | 22199227 | |
| 917 | Phosphorylation | PSFISLQSSPSPGAQ CCCEECCCCCCCCCC | 49.89 | 22199227 | |
| 918 | Phosphorylation | SFISLQSSPSPGAQP CCEECCCCCCCCCCC | 19.21 | 25159151 | |
| 920 | Phosphorylation | ISLQSSPSPGAQPRV EECCCCCCCCCCCCC | 37.60 | 25159151 | |
| 940 | Ubiquitination | PLTKDSGKPLHIKPR CCCCCCCCCCCCCCC | 48.64 | - | |
| 945 | Ubiquitination | SGKPLHIKPRL---- CCCCCCCCCCC---- | 17.21 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZC3H3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZC3H3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZC3H3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-917; SER-918 ANDSER-920, AND MASS SPECTROMETRY. | |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-571, AND MASSSPECTROMETRY. | |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617, AND MASSSPECTROMETRY. | |
| "Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383; SER-569 ANDSER-571, AND MASS SPECTROMETRY. | |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207 AND SER-211, ANDMASS SPECTROMETRY. | |
