ERAL1_HUMAN - dbPTM
ERAL1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ERAL1_HUMAN
UniProt AC O75616
Protein Name GTPase Era, mitochondrial
Gene Name ERAL1
Organism Homo sapiens (Human).
Sequence Length 437
Subcellular Localization Mitochondrion matrix. Mitochondrion inner membrane
Peripheral membrane protein. Localizes on the matrix side on the mitochondrial inner membrane.
Protein Description Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly..
Protein Sequence MAAPSWRGARLVQSVLRVWQVGPHVARERVIPFSSLLGFQRRCVSCVAGSAFSGPRLASASRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLGAPNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQVILLDTPGIISPGKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDCLKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWPHFKEIFMLSALSQEDVKTLKQYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHLPQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLMDIFLCDVDIRLSVKLLK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MAAPSWRGARLV
---CCCCCHHHHHHH		25.3624719451
45PhosphorylationGFQRRCVSCVAGSAF
CCHHHHHHHHCCCCC		13.3928258704
53PhosphorylationCVAGSAFSGPRLASA
HHCCCCCCCHHHHCC		47.8324719451
61PhosphorylationGPRLASASRSNGQGS
CHHHHCCCCCCCCCC		33.4722964224
91PhosphorylationTPCVPAVSMNRDEQD
CCCCEEEECCCCCCC		16.67-
126UbiquitinationLGAPNAGKSTLSNQL
ECCCCCCCCHHHHHH		37.5523503661
161PhosphorylationGVITEKETQVILLDT
CEEECCCCEEEEECC		38.9223312004
168PhosphorylationTQVILLDTPGIISPG
CEEEEECCCCCCCCC		24.3129978859
173PhosphorylationLDTPGIISPGKQKRH
ECCCCCCCCCCCCCC		26.1929255136
175UbiquitinationTPGIISPGKQKRHHL
CCCCCCCCCCCCCCC		37.9323503661
176UbiquitinationPGIISPGKQKRHHLE
CCCCCCCCCCCCCCE		56.9023503661
177UbiquitinationGIISPGKQKRHHLEL
CCCCCCCCCCCCCEE		54.6623503661
178UbiquitinationIISPGKQKRHHLELS
CCCCCCCCCCCCEEH		58.1323503661
216PhosphorylationKWTRNQLSPQLLRCL
CCHHCCCCHHHHHHH		10.8021815630
272UbiquitinationKMRQAFHSHPGTHCP
EEHHHHHCCCCCCCC		25.5629967540
283UbiquitinationTHCPSPAVKDPNTQS
CCCCCCCCCCCCCCC		9.0829967540
284UbiquitinationHCPSPAVKDPNTQSV
CCCCCCCCCCCCCCC		70.3629967540
288UbiquitinationPAVKDPNTQSVGNPQ
CCCCCCCCCCCCCHH		27.8423503661
305UbiquitinationGWPHFKEIFMLSALS
CCHHHHHHHHHHCCC		2.2522817900
310UbiquitinationKEIFMLSALSQEDVK
HHHHHHHCCCHHHHH		13.7921890473
315UbiquitinationLSALSQEDVKTLKQY
HHCCCHHHHHHHHHH		39.3121890473
354UbiquitinationICANIIREKLLEHLP
HHHHHHHHHHHHCCC		37.3329967540
355UbiquitinationCANIIREKLLEHLPQ
HHHHHHHHHHHCCCC		48.8229967540
370UbiquitinationEVPYNVQQKTAVWEE
CCCCCCCCCCEEEEC		40.5623503661
371UbiquitinationVPYNVQQKTAVWEEG
CCCCCCCCCEEEECC		22.7423503661
387UbiquitinationGGELVIQQKLLVPKE
CCEEEEEEEEECCHH		27.5222817900
388UbiquitinationGELVIQQKLLVPKES
CEEEEEEEEECCHHH		27.6722817900
392UbiquitinationIQQKLLVPKESYVKL
EEEEEECCHHHHEEE		34.3721890473
393UbiquitinationQQKLLVPKESYVKLL
EEEEECCHHHHEEEE		52.3822817900
393 (in isoform 1)Ubiquitination-52.3821890473
397UbiquitinationLVPKESYVKLLIGPK
ECCHHHHEEEEECCC		4.9821890473
398UbiquitinationVPKESYVKLLIGPKG
CCHHHHEEEEECCCC		29.3722817900
398 (in isoform 1)Ubiquitination-29.3721890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
173SPhosphorylationKinaseCDK2P24941
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ERAL1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ERAL1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LX15B_HUMANALOX15Bphysical
22939629
FA50B_HUMANFAM50Bphysical
22939629
S2546_HUMANSLC25A46physical
22939629
CEP44_HUMANCEP44physical
25416956
CO1A1_HUMANCOL1A1physical
26186194
ATPF1_HUMANATPAF1physical
26186194
CO1A2_HUMANCOL1A2physical
26186194
FABD_HUMANMCATphysical
26186194
CO3A1_HUMANCOL3A1physical
26186194
CO1A2_HUMANCOL1A2physical
28514442
CO1A1_HUMANCOL1A1physical
28514442
ATPF1_HUMANATPAF1physical
28514442
LRP1_HUMANLRP1physical
28514442
CO3A1_HUMANCOL3A1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ERAL1_HUMAN

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Related Literatures of Post-Translational Modification

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