ATPF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATPF1_HUMAN
• UniProt AC: Q5TC12
• Protein Name: ATP synthase mitochondrial F1 complex assembly factor 1
• Gene Name: ATPAF1
• Organism: Homo sapiens (Human).
• Sequence Length: 328
• Subcellular Localization: Mitochondrion.
• Protein Description: May play an essential role for the assembly of the mitochondrial F1-F0 complex..
• Protein Sequence: MAAVVVAAAGGAGPAVLQVAGLYRGLCAVRSRALGLGLVSPAQLRVFPVRPGSGRPEGGADSSGVGAEAELQANPFYDRYRDKIQLLRRSDPAAFESRLEKRSEFRKQPVGHSRQGDFIKCVEQKTDALGKQSVNRGFTKDKTLSSIFNIEMVKEKTAEEIKQIWQQYFAAKDTVYAVIPAEKFDLIWNRAQSCPTFLCALPRREGYEFFVGQWTGTELHFTALINIQTRGEAAASQLILYHYPELKEEKGIVLMTAEMDSTFLNVAEAQCIANQVQLFYATDRKETYGLVETFNLRPNEFKYMSVIAELEQSGLGAELKCAQNQNKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	ALGLGLVSPAQLRVF HHCCCCCCHHHEEEE	21.40	22199227
63	Phosphorylation	PEGGADSSGVGAEAE CCCCCCCCCCCCHHH	37.74	-
83	Ubiquitination	FYDRYRDKIQLLRRS CHHHHHHHHHHHHHC	24.29	-
90	Phosphorylation	KIQLLRRSDPAAFES HHHHHHHCCHHHHHH	41.32	21815630
97	Phosphorylation	SDPAAFESRLEKRSE CCHHHHHHHHHHHHH	35.39	18785766
106	Ubiquitination	LEKRSEFRKQPVGHS HHHHHHHHCCCCCCC	32.42	-
113	Phosphorylation	RKQPVGHSRQGDFIK HCCCCCCCCCCCHHH	21.99	-
120	Ubiquitination	SRQGDFIKCVEQKTD CCCCCHHHHHCCCCC	32.02	-
125	Acetylation	FIKCVEQKTDALGKQ HHHHHCCCCCCCCCC	34.56	25953088
125	Ubiquitination	FIKCVEQKTDALGKQ HHHHHCCCCCCCCCC	34.56	-
133	Phosphorylation	TDALGKQSVNRGFTK CCCCCCCCCCCCCCC	25.50	28857561
142	Ubiquitination	NRGFTKDKTLSSIFN CCCCCCCCHHHHHCC	53.58	-
143	Ubiquitination	RGFTKDKTLSSIFNI CCCCCCCHHHHHCCH	41.84	-
143	Phosphorylation	RGFTKDKTLSSIFNI CCCCCCCHHHHHCCH	41.84	21406692
145	Phosphorylation	FTKDKTLSSIFNIEM CCCCCHHHHHCCHHH	26.98	21406692
146	Phosphorylation	TKDKTLSSIFNIEMV CCCCHHHHHCCHHHH	34.02	21406692
148	Ubiquitination	DKTLSSIFNIEMVKE CCHHHHHCCHHHHCH	9.00	-
154	Ubiquitination	IFNIEMVKEKTAEEI HCCHHHHCHHCHHHH	52.78	-
165	Ubiquitination	AEEIKQIWQQYFAAK HHHHHHHHHHHHCCC	4.09	-
176	Phosphorylation	FAAKDTVYAVIPAEK HCCCCCEEEEEEHHH	9.39	-
199	Phosphorylation	QSCPTFLCALPRREG CCCCEEEEECCCCCC	2.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATPF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATPF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATPF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATPB_HUMAN	ATP5B	physical	11410595

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.