dbPTM

S2546_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	S2546_HUMAN
UniProt AC	Q96AG3
Protein Name	Solute carrier family 25 member 46
Gene Name	SLC25A46
Organism	Homo sapiens (Human).
Sequence Length	418
Subcellular Localization	Mitochondrion outer membrane Multi-pass membrane protein .
Protein Description	May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission..
Protein Sequence	MHPRRPDGFDGLGYRGGARDEQGFGGAFPARSFSTGSDLGHWVTTPPDIPGSRNLHWGEKSPPYGVPTTSTPYEGPTEEPFSSGGGGSVQGQSSEQLNRFAGFGIGLASLFTENVLAHPCIVLRRQCQVNYHAQHYHLTPFTVINIMYSFNKTQGPRALWKGMGSTFIVQGVTLGAEGIISEFTPLPREVLHKWSPKQIGEHLLLKSLTYVVAMPFYSASLIETVQSEIIRDNTGILECVKEGIGRVIGMGVPHSKRLLPLLSLIFPTVLHGVLHYIISSVIQKFVLLILKRKTYNSHLAESTSPVQSMLDAYFPELIANFAASLCSDVILYPLETVLHRLHIQGTRTIIDNTDLGYEVLPINTQYEGMRDCINTIRQEEGVFGFYKGFGAVIIQYTLHAAVLQITKIIYSTLLQNNI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	DGFDGLGYRGGARDE CCCCCCCCCCCCCCC	15.89	28555341
15	Methylation	GFDGLGYRGGARDEQ CCCCCCCCCCCCCCC	34.96	115917093
32	Phosphorylation	GGAFPARSFSTGSDL CCCCCCCCCCCCCCC	26.17	23401153
34	Phosphorylation	AFPARSFSTGSDLGH CCCCCCCCCCCCCCC	32.86	22167270
35	Phosphorylation	FPARSFSTGSDLGHW CCCCCCCCCCCCCCC	38.40	30266825
37	Phosphorylation	ARSFSTGSDLGHWVT CCCCCCCCCCCCCCC	29.74	30266825
44	Phosphorylation	SDLGHWVTTPPDIPG CCCCCCCCCCCCCCC	28.52	30266825
45	Phosphorylation	DLGHWVTTPPDIPGS CCCCCCCCCCCCCCC	24.17	25159151
47	Ubiquitination	GHWVTTPPDIPGSRN CCCCCCCCCCCCCCC	50.50	-
51	Ubiquitination	TTPPDIPGSRNLHWG CCCCCCCCCCCCCCC	39.30	-
52	Phosphorylation	TPPDIPGSRNLHWGE CCCCCCCCCCCCCCC	16.79	30266825
60	Ubiquitination	RNLHWGEKSPPYGVP CCCCCCCCCCCCCCC	65.41	21906983
60	Ubiquitination	RNLHWGEKSPPYGVP CCCCCCCCCCCCCCC	65.41	21890473
61	Phosphorylation	NLHWGEKSPPYGVPT CCCCCCCCCCCCCCC	27.14	28464451
64	Phosphorylation	WGEKSPPYGVPTTST CCCCCCCCCCCCCCC	33.85	22199227
68	Phosphorylation	SPPYGVPTTSTPYEG CCCCCCCCCCCCCCC	30.85	22199227
69	Phosphorylation	PPYGVPTTSTPYEGP CCCCCCCCCCCCCCC	25.24	22199227
70	Phosphorylation	PYGVPTTSTPYEGPT CCCCCCCCCCCCCCC	29.84	22199227
71	Phosphorylation	YGVPTTSTPYEGPTE CCCCCCCCCCCCCCC	28.00	22199227
73	Phosphorylation	VPTTSTPYEGPTEEP CCCCCCCCCCCCCCC	33.34	26434776
77	Phosphorylation	STPYEGPTEEPFSSG CCCCCCCCCCCCCCC	64.93	28857561
88	Phosphorylation	FSSGGGGSVQGQSSE CCCCCCCCCCCCCHH	17.97	27080861
95	Ubiquitination	SVQGQSSEQLNRFAG CCCCCCHHHHHHHCC	65.42	-
136	Phosphorylation	VNYHAQHYHLTPFTV CCCCCCCCCCCCEEE	6.09	-
142	Phosphorylation	HYHLTPFTVINIMYS CCCCCCEEEEEEEEE	22.98	25332170
148	Phosphorylation	FTVINIMYSFNKTQG EEEEEEEEECCCCCC	13.30	-
149	Phosphorylation	TVINIMYSFNKTQGP EEEEEEEECCCCCCC	12.64	-
193	Ubiquitination	LPREVLHKWSPKQIG CCHHHHHCCCHHHHH	45.25	-
195	Phosphorylation	REVLHKWSPKQIGEH HHHHHCCCHHHHHHH	27.33	24719451
197	Ubiquitination	VLHKWSPKQIGEHLL HHHCCCHHHHHHHHH	49.37	21890473
197	Ubiquitination	VLHKWSPKQIGEHLL HHHCCCHHHHHHHHH	49.37	21890473
197	Ubiquitination	VLHKWSPKQIGEHLL HHHCCCHHHHHHHHH	49.37	21890473
210	Phosphorylation	LLLKSLTYVVAMPFY HHHHHHHHHHHCCCC	9.75	-
241	Ubiquitination	TGILECVKEGIGRVI CCHHHHHHHCCCCHH	62.98	-
364	Phosphorylation	YEVLPINTQYEGMRD CEEECCCCCCCCHHH	32.99	27307780
366	Phosphorylation	VLPINTQYEGMRDCI EECCCCCCCCHHHHH	16.65	27307780
375	Phosphorylation	GMRDCINTIRQEEGV CHHHHHHHHHHHHCC	9.53	27307780
396	Phosphorylation	FGAVIIQYTLHAAVL CCCHHHHHHHHHHHH	10.81	29514088
397	Phosphorylation	GAVIIQYTLHAAVLQ CCHHHHHHHHHHHHH	8.83	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of S2546_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of S2546_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of S2546_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SCFD1_HUMAN	SCFD1	physical	22939629
FUND1_HUMAN	FUNDC1	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of S2546_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-45, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-45, AND MASSSPECTROMETRY.	18691976 [Abstract]