| UniProt ID | FABD_HUMAN | |
|---|---|---|
| UniProt AC | Q8IVS2 | |
| Protein Name | Malonyl-CoA-acyl carrier protein transacylase, mitochondrial | |
| Gene Name | MCAT | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 390 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria.. | |
| Protein Sequence | MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGLYAVKIRAEAMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSLGIENPVCEVSNYLFPDCRVISGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEPAVEPLTQALKAVDIKKPLVSVYSNVHAHRYRHPGHIHKLLAQQLVSPVKWEQTMHAIYERKKGRGFPQTFEVGPGRQLGAILKSCNMQAWKSYSAVDVLQTLEHVDLDPQEPPR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 79 | Methylation | SQVVGMGRGLLNYPR CCEEECCCCHHCCHH | 24.56 | 54557273 | |
| 250 | Ubiquitination | EALRFLQKNSSKFHF HHHHHHHHCCCCCCE | 62.03 | 29967540 | |
| 314 | Succinylation | RHPGHIHKLLAQQLV CCHHHHHHHHHHHCC | 44.59 | - | |
| 314 | Succinylation | RHPGHIHKLLAQQLV CCHHHHHHHHHHHCC | 44.59 | - | |
| 322 | Phosphorylation | LLAQQLVSPVKWEQT HHHHHCCCCCCHHHH | 32.35 | 21406692 | |
| 325 | Sumoylation | QQLVSPVKWEQTMHA HHCCCCCCHHHHHHH | 48.69 | - | |
| 325 | Acetylation | QQLVSPVKWEQTMHA HHCCCCCCHHHHHHH | 48.69 | 25038526 | |
| 325 | Sumoylation | QQLVSPVKWEQTMHA HHCCCCCCHHHHHHH | 48.69 | 17000644 | |
| 340 | Methylation | IYERKKGRGFPQTFE HHHHHCCCCCCCCEE | 53.08 | 54557281 | |
| 359 | Malonylation | RQLGAILKSCNMQAW HHHHHHHHHCCCCHH | 47.01 | 26320211 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FABD_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FABD_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FABD_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RT16_HUMAN | MRPS16 | physical | 22939629 | |
| ITAV_HUMAN | ITGAV | physical | 22939629 | |
| SPCS2_HUMAN | SPCS2 | physical | 22939629 | |
| PTN1_HUMAN | PTPN1 | physical | 22939629 | |
| RAVR1_HUMAN | RAVER1 | physical | 22939629 | |
| SPTN1_HUMAN | SPTAN1 | physical | 22939629 | |
| GLYC_HUMAN | SHMT1 | physical | 22939629 | |
| TAP1_HUMAN | TAP1 | physical | 22939629 | |
| SPEB_HUMAN | AGMAT | physical | 22939629 | |
| TMM43_HUMAN | TMEM43 | physical | 22939629 | |
| RUSD2_HUMAN | RPUSD2 | physical | 26344197 | |
| HEM1_HUMAN | ALAS1 | physical | 28514442 | |
| TAF5_HUMAN | TAF5 | physical | 28514442 | |
| ZY11B_HUMAN | ZYG11B | physical | 28514442 | |
| MASU1_HUMAN | MALSU1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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