CO3A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO3A1_HUMAN
• UniProt AC: P02461
• Protein Name: Collagen alpha-1(III) chain
• Gene Name: COL3A1
• Organism: Homo sapiens (Human).
• Sequence Length: 1466
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12..
• Protein Sequence: MMSFVQKGSWLLLALLHPTIILAQQEAVEGGCSHLGQSYADRDVWKPEPCQICVCDSGSVLCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGETCISANPLNVPRKHWWTDSSAEKKHVWFGESMDGGFQFSYGNPELPEDVLDVHLAFLRLLSSRASQNITYHCKNSIAYMDQASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPIVDIAPYDIGGPDQEFGVDVGPVCFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	O-linked_Glycosylation	PQPPTAPTRPPNGQG CCCCCCCCCCCCCCC	54.03	OGP
143	Phosphorylation	GPPGICESCPTGPQN CCCCCCCCCCCCCCC	22.45	27251275
146	O-linked_Glycosylation	GICESCPTGPQNYSP CCCCCCCCCCCCCCC	66.86	OGP
152	O-linked_Glycosylation	PTGPQNYSPQYDSYD CCCCCCCCCCCCCCC	17.05	OGP
173	Hydroxylation	VGGLAGYPGPAGPPG ECCCCCCCCCCCCCC	41.18	557335
179	Hydroxylation	YPGPAGPPGPPGPPG CCCCCCCCCCCCCCC	67.99	557335
182	Hydroxylation	PAGPPGPPGPPGTSG CCCCCCCCCCCCCCC	74.06	557335
185	Hydroxylation	PPGPPGPPGTSGHPG CCCCCCCCCCCCCCC	65.69	557335
191	Hydroxylation	PPGTSGHPGSPGSPG CCCCCCCCCCCCCCC	48.78	557335
194	Hydroxylation	TSGHPGSPGSPGYQG CCCCCCCCCCCCCCC	53.87	557335
197	Hydroxylation	HPGSPGSPGYQGPPG CCCCCCCCCCCCCCC	51.96	557335
203	Hydroxylation	SPGYQGPPGEPGQAG CCCCCCCCCCCCCCC	67.61	557335
206	Hydroxylation	YQGPPGEPGQAGPSG CCCCCCCCCCCCCCC	46.22	557335
215	Hydroxylation	QAGPSGPPGPPGAIG CCCCCCCCCCCCCCC	72.02	557335
218	Hydroxylation	PSGPPGPPGAIGPSG CCCCCCCCCCCCCCC	51.25	557335
236	Hydroxylation	KDGESGRPGRPGERG CCCCCCCCCCCCCCC	46.82	557335
239	Hydroxylation	ESGRPGRPGERGLPG CCCCCCCCCCCCCCC	55.71	557335
245	Hydroxylation	RPGERGLPGPPGIKG CCCCCCCCCCCCCCC	56.95	557335
248	Hydroxylation	ERGLPGPPGIKGPAG CCCCCCCCCCCCCCC	64.16	557335
257	Hydroxylation	IKGPAGIPGFPGMKG CCCCCCCCCCCCCCC	37.14	557335
260	Hydroxylation	PAGIPGFPGMKGHRG CCCCCCCCCCCCCCC	48.13	557335
263	Hydroxylation	IPGFPGMKGHRGFDG CCCCCCCCCCCCCCC	58.44	557335
263	O-linked_Glycosylation	IPGFPGMKGHRGFDG CCCCCCCCCCCCCCC	58.44	-
281	Hydroxylation	EKGETGAPGLKGENG CCCCCCCCCCCCCCC	50.42	557335
284	Hydroxylation	ETGAPGLKGENGLPG CCCCCCCCCCCCCCC	70.82	557335
290	Hydroxylation	LKGENGLPGENGAPG CCCCCCCCCCCCCCC	49.83	557335
296	Hydroxylation	LPGENGAPGPMGPRG CCCCCCCCCCCCCCC	49.14	557335
305	Hydroxylation	PMGPRGAPGERGRPG CCCCCCCCCCCCCCC	48.26	557335
311	Hydroxylation	APGERGRPGLPGAAG CCCCCCCCCCCCCCC	52.04	557335
314	Hydroxylation	ERGRPGLPGAAGARG CCCCCCCCCCCCCCC	35.97	557335
332	Hydroxylation	ARGSDGQPGPPGPPG CCCCCCCCCCCCCCC	63.89	557335
335	Hydroxylation	SDGQPGPPGPPGTAG CCCCCCCCCCCCCCC	74.06	557335
338	Hydroxylation	QPGPPGPPGTAGFPG CCCCCCCCCCCCCCC	59.69	557335
340	Phosphorylation	GPPGPPGTAGFPGSP CCCCCCCCCCCCCCC	29.40	23403867
344	Hydroxylation	PPGTAGFPGSPGAKG CCCCCCCCCCCCCCC	41.24	557335
346	Phosphorylation	GTAGFPGSPGAKGEV CCCCCCCCCCCCCCC	22.02	23403867
347	Hydroxylation	TAGFPGSPGAKGEVG CCCCCCCCCCCCCCC	53.31	557335
359	Hydroxylation	EVGPAGSPGSNGAPG CCCCCCCCCCCCCCC	49.68	557335
365	Hydroxylation	SPGSNGAPGQRGEPG CCCCCCCCCCCCCCC	40.63	557335
371	Hydroxylation	APGQRGEPGPQGHAG CCCCCCCCCCCCCCC	63.69	557335
383	Hydroxylation	HAGAQGPPGPPGING CCCCCCCCCCCCCCC	74.81	557335
386	Hydroxylation	AQGPPGPPGINGSPG CCCCCCCCCCCCCCC	63.31	557335
392	Hydroxylation	PPGINGSPGGKGEMG CCCCCCCCCCCCCCC	57.88	557335
404	Hydroxylation	EMGPAGIPGAPGLMG CCCCCCCCCCCCCCC	31.79	687591
407	Hydroxylation	PAGIPGAPGLMGARG CCCCCCCCCCCCCCC	42.22	687591
416	Hydroxylation	LMGARGPPGPAGANG CCCCCCCCCCCCCCC	65.31	687591
425	Hydroxylation	PAGANGAPGLRGGAG CCCCCCCCCCCCCCC	43.69	687591
434	Hydroxylation	LRGGAGEPGKNGAKG CCCCCCCCCCCCCCC	59.13	687591
443	Hydroxylation	KNGAKGEPGPRGERG CCCCCCCCCCCCCCC	67.75	687591
455	Hydroxylation	ERGEAGIPGVPGAKG CCCCCCCCCCCCCCC	36.49	687591
458	Hydroxylation	EAGIPGVPGAKGEDG CCCCCCCCCCCCCCC	42.83	687591
470	Hydroxylation	EDGKDGSPGEPGANG CCCCCCCCCCCCCCC	57.61	687591
473	Hydroxylation	KDGSPGEPGANGLPG CCCCCCCCCCCCCCC	53.78	687591
479	Hydroxylation	EPGANGLPGAAGERG CCCCCCCCCCCCCCC	31.60	687591
488	Hydroxylation	AAGERGAPGFRGPAG CCCCCCCCCCCCCCC	45.33	687591
500	Hydroxylation	PAGPNGIPGEKGPAG CCCCCCCCCCCCCCC	46.41	687591
512	Hydroxylation	PAGERGAPGPAGPRG CCCCCCCCCCCCCCC	52.72	687591
524	Hydroxylation	PRGAAGEPGRDGVPG CCCCCCCCCCCCCCC	42.05	687591
530	Hydroxylation	EPGRDGVPGGPGMRG CCCCCCCCCCCCCCC	47.77	687591
533	Hydroxylation	RDGVPGGPGMRGMPG CCCCCCCCCCCCCCC	39.04	687591
539	Hydroxylation	GPGMRGMPGSPGGPG CCCCCCCCCCCCCCC	42.82	687591
542	Hydroxylation	MRGMPGSPGGPGSDG CCCCCCCCCCCCCCC	58.64	687591
545	Hydroxylation	MPGSPGGPGSDGKPG CCCCCCCCCCCCCCC	45.06	687591
551	Hydroxylation	GPGSDGKPGPPGSQG CCCCCCCCCCCCCCC	67.08	687591
554	Hydroxylation	SDGKPGPPGSQGESG CCCCCCCCCCCCCCC	62.07	687591
563	Hydroxylation	SQGESGRPGPPGPSG CCCCCCCCCCCCCCC	64.27	687591
566	Hydroxylation	ESGRPGPPGPSGPRG CCCCCCCCCCCCCCC	73.56	687591
575	Hydroxylation	PSGPRGQPGVMGFPG CCCCCCCCCCCCCCC	39.92	687591
581	Hydroxylation	QPGVMGFPGPKGNDG CCCCCCCCCCCCCCC	53.07	687591
590	Hydroxylation	PKGNDGAPGKNGERG CCCCCCCCCCCCCCC	60.88	687591
599	Hydroxylation	KNGERGGPGGPGPQG CCCCCCCCCCCCCCC	47.60	687591
602	Hydroxylation	ERGGPGGPGPQGPPG CCCCCCCCCCCCCCC	58.15	687591
608	Hydroxylation	GPGPQGPPGKNGETG CCCCCCCCCCCCCCC	73.54	687591
620	Hydroxylation	ETGPQGPPGPTGPGG CCCCCCCCCCCCCCC	69.12	687591
635	Hydroxylation	DKGDTGPPGPQGLQG CCCCCCCCCCCCCCC	69.32	687591
644	Hydroxylation	PQGLQGLPGTGGPPG CCCCCCCCCCCCCCC	45.16	687591
650	Hydroxylation	LPGTGGPPGENGKPG CCCCCCCCCCCCCCC	67.04	687591
656	Hydroxylation	PPGENGKPGEPGPKG CCCCCCCCCCCCCCC	54.50	687591
659	Hydroxylation	ENGKPGEPGPKGDAG CCCCCCCCCCCCCCC	71.01	687591
661	Hydroxylation	GKPGEPGPKGDAGAP CCCCCCCCCCCCCCC	48.44	687591
668	Hydroxylation	PKGDAGAPGAPGGKG CCCCCCCCCCCCCCC	38.26	687591
671	Hydroxylation	DAGAPGAPGGKGDAG CCCCCCCCCCCCCCC	58.97	687591
680	Hydroxylation	GKGDAGAPGERGPPG CCCCCCCCCCCCCCC	44.23	687591
686	Hydroxylation	APGERGPPGLAGAPG CCCCCCCCCCCCCCC	53.94	687591
692	Hydroxylation	PPGLAGAPGLRGGAG CCCCCCCCCCCCCCC	41.24	687591
701	Hydroxylation	LRGGAGPPGPEGGKG CCCCCCCCCCCCCCC	70.79	687591
703	Hydroxylation	GGAGPPGPEGGKGAA CCCCCCCCCCCCCCC	42.72	687591
713	Hydroxylation	GKGAAGPPGPPGAAG CCCCCCCCCCCCCCC	67.99	687591
716	Hydroxylation	AAGPPGPPGAAGTPG CCCCCCCCCCCCCCC	51.47	687591
722	Hydroxylation	PPGAAGTPGLQGMPG CCCCCCCCCCCCCCC	40.35	687591
728	Hydroxylation	TPGLQGMPGERGGLG CCCCCCCCCCCCCCC	48.60	6246925
737	Hydroxylation	ERGGLGSPGPKGDKG CCCCCCCCCCCCCCC	62.40	6246925
746	Hydroxylation	PKGDKGEPGGPGADG CCCCCCCCCCCCCCC	62.80	6246925
749	Hydroxylation	DKGEPGGPGADGVPG CCCCCCCCCCCCCCC	40.49	6246925
755	Hydroxylation	GPGADGVPGKDGPRG CCCCCCCCCCCCCCC	50.04	6246925
757	Ubiquitination	GADGVPGKDGPRGPT CCCCCCCCCCCCCCC	54.14	-
770	Hydroxylation	PTGPIGPPGPAGQPG CCCCCCCCCCCCCCC	57.07	6246925
776	Hydroxylation	PPGPAGQPGDKGEGG CCCCCCCCCCCCCCC	52.62	6246925
785	Hydroxylation	DKGEGGAPGLPGIAG CCCCCCCCCCCCCCC	48.40	6246925
788	Hydroxylation	EGGAPGLPGIAGPRG CCCCCCCCCCCCCCC	37.75	6246925
797	Hydroxylation	IAGPRGSPGERGETG CCCCCCCCCCCCCCC	52.03	6246925
806	Hydroxylation	ERGETGPPGPAGFPG CCCCCCCCCCCCCCC	63.85	6246925
812	Hydroxylation	PPGPAGFPGAPGQNG CCCCCCCCCCCCCCC	36.80	6246925
815	Hydroxylation	PAGFPGAPGQNGEPG CCCCCCCCCCCCCCC	51.31	6246925
821	Hydroxylation	APGQNGEPGGKGERG CCCCCCCCCCCCCCC	59.23	6246925
830	Hydroxylation	GKGERGAPGEKGEGG CCCCCCCCCCCCCCC	55.06	6246925
839	Hydroxylation	EKGEGGPPGVAGPPG CCCCCCCCCCCCCCC	53.84	6246925
845	Hydroxylation	PPGVAGPPGGSGPAG CCCCCCCCCCCCCCC	59.88	6246925
854	Hydroxylation	GSGPAGPPGPQGVKG CCCCCCCCCCCCCCC	67.20	6246925
860	Hydroxylation	PPGPQGVKGERGSPG CCCCCCCCCCCCCCC	62.98	6246925
866	Hydroxylation	VKGERGSPGGPGAAG CCCCCCCCCCCCCCC	55.36	6246925
869	Hydroxylation	ERGSPGGPGAAGFPG CCCCCCCCCCCCCCC	34.85	6246925
875	Hydroxylation	GPGAAGFPGARGLPG CCCCCCCCCCCCCCC	34.32	6246925
881	Hydroxylation	FPGARGLPGPPGSNG CCCCCCCCCCCCCCC	56.95	6246925
884	Hydroxylation	ARGLPGPPGSNGNPG CCCCCCCCCCCCCCC	65.83	6246925
890	Hydroxylation	PPGSNGNPGPPGPSG CCCCCCCCCCCCCCC	59.05	6246925
892	Hydroxylation	GSNGNPGPPGPSGSP CCCCCCCCCCCCCCC	31.75	6246925
899	Hydroxylation	PPGPSGSPGKDGPPG CCCCCCCCCCCCCCC	58.33	6246925
905	Hydroxylation	SPGKDGPPGPAGNTG CCCCCCCCCCCCCCC	67.91	6246925
914	Hydroxylation	PAGNTGAPGSPGVSG CCCCCCCCCCCCCCC	45.18	6246925
916	Phosphorylation	GNTGAPGSPGVSGPK CCCCCCCCCCCCCCC	19.88	27251275
917	Hydroxylation	NTGAPGSPGVSGPKG CCCCCCCCCCCCCCC	53.79	6246925
929	Hydroxylation	PKGDAGQPGEKGSPG CCCCCCCCCCCCCCC	52.58	6246925
934	Phosphorylation	GQPGEKGSPGAQGPP CCCCCCCCCCCCCCC	31.09	28857561
935	Hydroxylation	QPGEKGSPGAQGPPG CCCCCCCCCCCCCCC	51.30	6246925
941	Hydroxylation	SPGAQGPPGAPGPLG CCCCCCCCCCCCCCC	59.40	6246925
944	Hydroxylation	AQGPPGAPGPLGIAG CCCCCCCCCCCCCCC	51.34	6246925
962	Hydroxylation	ARGLAGPPGMPGPRG CCCCCCCCCCCCCCC	51.28	6246925
965	Hydroxylation	LAGPPGMPGPRGSPG CCCCCCCCCCCCCCC	56.40	7016180
971	Hydroxylation	MPGPRGSPGPQGVKG CCCCCCCCCCCCCCC	62.40	7016180
977	Hydroxylation	SPGPQGVKGESGKPG CCCCCCCCCCCCCCC	64.88	7016180
983	Hydroxylation	VKGESGKPGANGLSG CCCCCCCCCCCCCCC	51.13	7016180
995	Hydroxylation	LSGERGPPGPQGLPG CCCCCCCCCCCCCCC	70.67	7016180
1001	Hydroxylation	PPGPQGLPGLAGTAG CCCCCCCCCCCCCCC	42.44	7016180
1010	Hydroxylation	LAGTAGEPGRDGNPG CCCCCCCCCCCCCCC	42.05	7016180
1016	Hydroxylation	EPGRDGNPGSDGLPG CCCCCCCCCCCCCCC	49.55	7016180
1022	Hydroxylation	NPGSDGLPGRDGSPG CCCCCCCCCCCCCCC	41.10	7016180
1027	Phosphorylation	GLPGRDGSPGGKGDR CCCCCCCCCCCCCCC	25.35	28258704
1028	Hydroxylation	LPGRDGSPGGKGDRG CCCCCCCCCCCCCCC	62.17	7016180
1040	Hydroxylation	DRGENGSPGAPGAPG CCCCCCCCCCCCCCC	44.35	7016180
1043	Hydroxylation	ENGSPGAPGAPGHPG CCCCCCCCCCCCCCC	45.45	7016180
1046	Hydroxylation	SPGAPGAPGHPGPPG CCCCCCCCCCCCCCC	47.76	7016180
1049	Hydroxylation	APGAPGHPGPPGPVG CCCCCCCCCCCCCCC	64.00	7016180
1052	Hydroxylation	APGHPGPPGPVGPAG CCCCCCCCCCCCCCC	66.68	7016180
1076	Hydroxylation	PAGPAGAPGPAGSRG CCCCCCCCCCCCCCC	48.67	7016180
1085	Hydroxylation	PAGSRGAPGPQGPRG CCCCCCCCCCCCCCC	58.80	7016180
1094	Hydroxylation	PQGPRGDKGETGERG CCCCCCCCCCCCCCC	62.56	-
1106	Hydroxylation	ERGAAGIKGHRGFPG CCCCCCCCCCCCCCC	47.98	7016180
1112	Hydroxylation	IKGHRGFPGNPGAPG CCCCCCCCCCCCCCC	44.46	7016180
1115	Hydroxylation	HRGFPGNPGAPGSPG CCCCCCCCCCCCCCC	46.36	7016180
1118	Hydroxylation	FPGNPGAPGSPGPAG CCCCCCCCCCCCCCC	50.11	7016180
1121	Hydroxylation	NPGAPGSPGPAGQQG CCCCCCCCCCCCCCC	59.72	7016180
1133	Hydroxylation	QQGAIGSPGPAGPRG CCCCCCCCCCCCCCC	47.80	7016180
1145	O-linked_Glycosylation	PRGPVGPSGPPGKDG CCCCCCCCCCCCCCC	58.99	55825455
1148	Hydroxylation	PVGPSGPPGKDGTSG CCCCCCCCCCCCCCC	67.02	7016180
1157	Hydroxylation	KDGTSGHPGPIGPPG CCCCCCCCCCCCCCC	54.50	7016180
1163	Hydroxylation	HPGPIGPPGPRGNRG CCCCCCCCCCCCCCC	61.27	7016180
1174	Phosphorylation	GNRGERGSEGSPGHP CCCCCCCCCCCCCCC	45.03	27251275
1177	Phosphorylation	GERGSEGSPGHPGQP CCCCCCCCCCCCCCC	24.53	27251275
1178	Hydroxylation	ERGSEGSPGHPGQPG CCCCCCCCCCCCCCC	56.84	7016180
1181	Hydroxylation	SEGSPGHPGQPGPPG CCCCCCCCCCCCCCC	49.37	7016180
1184	Hydroxylation	SPGHPGQPGPPGPPG CCCCCCCCCCCCCCC	64.27	7016180
1187	Hydroxylation	HPGQPGPPGPPGAPG CCCCCCCCCCCCCCC	74.06	7016180
1190	Hydroxylation	QPGPPGPPGAPGPCC CCCCCCCCCCCCCCC	58.45	7016180
1193	Hydroxylation	PPGPPGAPGPCCGGV CCCCCCCCCCCCCHH	53.85	7016180
1220	Phosphorylation	AGGFAPYYGDEPMDF CCCCCCCCCCCCCEE	19.62	27251275
1237	Phosphorylation	NTDEIMTSLKSVNGQ CHHHHHHHHHHHCCE	19.20	16964243
1319	Phosphorylation	RKHWWTDSSAEKKHV CHHCCCCCCCCCEEE	24.87	27251275
1320	Phosphorylation	KHWWTDSSAEKKHVW HHCCCCCCCCCEEEE	43.17	24961811
1361	Phosphorylation	LAFLRLLSSRASQNI HHHHHHHHHHHHCCC	23.52	24719451
1362	Phosphorylation	AFLRLLSSRASQNIT HHHHHHHHHHHCCCE	31.66	24719451
1370	Phosphorylation	RASQNITYHCKNSIA HHHCCCEEEECCHHH	11.04	-
1378	Phosphorylation	HCKNSIAYMDQASGN EECCHHHHHHHCCCC	10.27	22817900
1383	Phosphorylation	IAYMDQASGNVKKAL HHHHHHCCCCHHHHH	25.85	19060867
1387	Acetylation	DQASGNVKKALKLMG HHCCCCHHHHHHHCC	36.01	20167786

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO3A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO3A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO3A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPRC_HUMAN	SPARC	physical	2745554
PDGFA_HUMAN	PDGFA	physical	8900172
PDGFB_HUMAN	PDGFB	physical	8900172

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 130020: Ehlers-Danlos syndrome 3 (EDS3)
• 130050: Ehlers-Danlos syndrome 4 (EDS4)
• 100070: Aortic aneurysm, familial abdominal (AAA)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

O-linked Glycosylation

"Covalent structure of collagen: amino acid sequence of cyanogenbromide peptides from the amino-terminal segment of type III collagenof human liver.";
Seyer J.M., Kang A.H.;
Biochemistry 16:1158-1164(1977).
Cited for: PROTEIN SEQUENCE OF 168-398.
PubMed: 557335

Phosphorylation

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1378 AND SER-1383, ANDMASS SPECTROMETRY.
PubMed: 17287340