LX15B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LX15B_HUMAN
• UniProt AC: O15296
• Protein Name: Arachidonate 15-lipoxygenase B
• Gene Name: ALOX15B
• Organism: Homo sapiens (Human).
• Sequence Length: 676
• Subcellular Localization: Isoform A: Nucleus. Other isoforms are excluded from the nucleus.; Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Predominantly cytosolic; becomes enriched at membranes upon calcium binding.
• Protein Description: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells..
• Protein Sequence: MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	VSVSIVGTRGESPPL EEEEEEECCCCCCCC	25.30	21712546
33	Phosphorylation	IVGTRGESPPLPLDN EEECCCCCCCCCCCC	34.34	27499020
198	Acetylation	AFAEMKIKGLLDRKG HHHHHHHHHHHCCCC	37.68	7960339
204	Acetylation	IKGLLDRKGLWRSLN HHHHHCCCCHHHHHH	59.01	7960351
452	Phosphorylation	NMKQLNYSLLCLPED HHHHHCCEEEECCHH	17.50	23403867
517	Phosphorylation	AWVREIFSKGFLNQE HHHHHHHHHCCCCCC	37.21	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LX15B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LX15B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LX15B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KBTB2_HUMAN	KBTBD2	physical	28514442
RP3A_HUMAN	RPH3A	physical	28514442
TAF5L_HUMAN	TAF5L	physical	28514442
KIF3A_HUMAN	KIF3A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.