KBTB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KBTB2_HUMAN
• UniProt AC: Q8IY47
• Protein Name: Kelch repeat and BTB domain-containing protein 2
• Gene Name: KBTBD2
• Organism: Homo sapiens (Human).
• Sequence Length: 623
• Protein Sequence: MSTQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPTYLFSTDGTEEFELDGEMVALPPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	CHKMVLATCSSYFRA HHHHHHHHHHHHHHH	14.57	22210691
53	Phosphorylation	KMVLATCSSYFRAMF HHHHHHHHHHHHHHH	24.58	22210691
54	Phosphorylation	MVLATCSSYFRAMFM HHHHHHHHHHHHHHH	30.36	22210691
55	Phosphorylation	VLATCSSYFRAMFMS HHHHHHHHHHHHHHH	4.84	22210691
62	Phosphorylation	YFRAMFMSGLSESKQ HHHHHHHHCCCCCCC	25.89	22210691
65	Phosphorylation	AMFMSGLSESKQTHV HHHHHCCCCCCCCEE	43.26	22210691
87	Phosphorylation	ATLQIIITYAYTGNL HHEEEEEEEEHHCCC	7.53	26074081
88	Phosphorylation	TLQIIITYAYTGNLA HEEEEEEEEHHCCCC	6.29	26074081
90	Phosphorylation	QIIITYAYTGNLAMN EEEEEEEHHCCCCCC	12.55	26074081
127	Ubiquitination	CREYLIKKINAENCV HHHHHHHHCCHHHHH	33.91	-
149	Ubiquitination	LFSCEELKQSAKRMV HHCHHHHHHHHHHHH	45.55	-
251	Ubiquitination	VVVQGLYKSMPKFFK HHHHHHHHHCCHHCC	45.37	-
297	Ubiquitination	PQAEKVYKLCSPPAD CCHHHHHHHHCCCHH	46.10	-
300	Phosphorylation	EKVYKLCSPPADLHK HHHHHHHCCCHHHHC	44.34	25159151
307	Ubiquitination	SPPADLHKVGTVVTP CCCHHHHCCCEEECC	50.05	-
310	Phosphorylation	ADLHKVGTVVTPDND HHHHCCCEEECCCCC	18.13	22817900
313	Phosphorylation	HKVGTVVTPDNDIYI HCCCEEECCCCCEEE	22.16	22817900
319	Phosphorylation	VTPDNDIYIAGGQVP ECCCCCEEEECCEEC	6.38	22817900
328	Ubiquitination	AGGQVPLKNTKTNHS ECCEECCCCCCCCCC	57.40	21906983
331	Ubiquitination	QVPLKNTKTNHSKTS EECCCCCCCCCCHHH	57.64	-
336	Ubiquitination	NTKTNHSKTSKLQTA CCCCCCCHHHHHHHH	49.63	-
339	Ubiquitination	TNHSKTSKLQTAFRT CCCCHHHHHHHHHHH	50.25	-
498	Phosphorylation	TVDGSSVTVEIYDVN CCCCCEEEEEEEECC	17.86	28674151
510	Ubiquitination	DVNKNEWKMAANIPA ECCCCEEEEECCCCC	16.69	-
518	Ubiquitination	MAANIPAKRYSDPCV EECCCCCHHCCCCCH	46.65	-
562	Phosphorylation	DLELDRWSLRQHISE CCCCCHHHHHHHHHH	17.99	24719451
587	Phosphorylation	RCTVGKLYPSCLEES CCCCCCCCHHHHCCC	9.15	25690035

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KBTB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KBTB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KBTB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL3_HUMAN	CUL3	physical	27708159
P85A_HUMAN	PIK3R1	physical	27708159

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.