dbPTM

NSD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NSD2_HUMAN
UniProt AC	O96028
Protein Name	Histone-lysine N-methyltransferase NSD2
Gene Name	NSD2 {ECO:0000312\|HGNC:HGNC:12766}
Organism	Homo sapiens (Human).
Sequence Length	1365
Subcellular Localization	Nucleus . Chromosome . Isoform 4: Cytoplasm.
Protein Description	Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment..
Protein Sequence	MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSPGDEPSESPYESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHDLGAASVRSTKTEKPPPEPGKPKGKRRRRRGWRRVTEGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEFSIKQSPLS ----CCCCCCCCCCC	31.97	24719451
8	Phosphorylation	MEFSIKQSPLSVQSV CCCCCCCCCCCHHHH	23.86	21815630
11	Phosphorylation	SIKQSPLSVQSVVKC CCCCCCCCHHHHHHH	22.84	22199227
14	Phosphorylation	QSPLSVQSVVKCIKM CCCCCHHHHHHHHHH	27.07	22199227
17	Acetylation	LSVQSVVKCIKMKQA CCHHHHHHHHHHHCC	28.25	25953088
30	Phosphorylation	QAPEILGSANGKTPS CCCHHHCCCCCCCCC	18.34	21815630
34	Acetylation	ILGSANGKTPSCEVN HHCCCCCCCCCCCCC	58.00	25953088
35	Phosphorylation	LGSANGKTPSCEVNR HCCCCCCCCCCCCCH	23.10	21815630
50	Ubiquitination	ECSVFLSKAQLSSSL HHEEEEEHHHHCHHH	42.15	29967540
54	Phosphorylation	FLSKAQLSSSLQEGV EEEHHHHCHHHHHHH	13.05	19691289
55	Phosphorylation	LSKAQLSSSLQEGVM EEHHHHCHHHHHHHH	43.59	19691289
56	Phosphorylation	SKAQLSSSLQEGVMQ EHHHHCHHHHHHHHH	30.60	25159151
78	Acetylation	LPFIPADKLKDLTSR CCCCCHHHHHHHHHH	60.59	23749302
78	Ubiquitination	LPFIPADKLKDLTSR CCCCCHHHHHHHHHH	60.59	29967540
80	Ubiquitination	FIPADKLKDLTSRVF CCCHHHHHHHHHHHH	57.33	29967540
97	Ubiquitination	EPGAHDAKLRFESQE CCCCCCCEEEEECCC	46.37	29967540
102	Phosphorylation	DAKLRFESQEMKGIG CCEEEEECCCCCCCC	28.82	17525332
110	Phosphorylation	QEMKGIGTPPNTTPI CCCCCCCCCCCCCCC	33.38	29255136
114	Phosphorylation	GIGTPPNTTPIKNGS CCCCCCCCCCCCCCC	39.46	29255136
115	Phosphorylation	IGTPPNTTPIKNGSP CCCCCCCCCCCCCCC	29.65	29255136
121	Phosphorylation	TTPIKNGSPEIKLKI CCCCCCCCCCCEEEE	28.84	23927012
136	Acetylation	TKTYMNGKPLFESSI EEEEECCEECEECCC	33.28	26051181
154	Phosphorylation	SAADVSQSEENGQKP CHHHCCHHHHCCCCH	39.10	-
172	Phosphorylation	ARRNRKRSIKYDSLL HHHHHHHHCHHHHHH	26.85	22617229
175	Phosphorylation	NRKRSIKYDSLLEQG HHHHHCHHHHHHHCC	14.75	21712546
177	Phosphorylation	KRSIKYDSLLEQGLV HHHCHHHHHHHCCHH	31.59	21712546
190	Phosphorylation	LVEAALVSKISSPSD HHHHHHHHHCCCCCC	25.73	26074081
191	Ubiquitination	VEAALVSKISSPSDK HHHHHHHHCCCCCCC	38.84	29967540
193	Phosphorylation	AALVSKISSPSDKKI HHHHHHCCCCCCCCC	39.68	26074081
194	Phosphorylation	ALVSKISSPSDKKIP HHHHHCCCCCCCCCC	31.71	28985074
196	Phosphorylation	VSKISSPSDKKIPAK HHHCCCCCCCCCCCC	65.10	26074081
198	Acetylation	KISSPSDKKIPAKKE HCCCCCCCCCCCCCC	57.87	23749302
220	Phosphorylation	DKDHLLKYNVGDLVW CHHHHHHCCCCHHHH	18.30	-
231	Phosphorylation	DLVWSKVSGYPWWPC HHHHHCCCCCCCCCE	36.02	25072903
233	Phosphorylation	VWSKVSGYPWWPCMV HHHCCCCCCCCCEEE	6.54	25072903
241	Phosphorylation	PWWPCMVSADPLLHS CCCCEEEECCHHHHC	10.48	25072903
248	Phosphorylation	SADPLLHSYTKLKGQ ECCHHHHCHHHCCCC	34.17	25072903
249	Phosphorylation	ADPLLHSYTKLKGQK CCHHHHCHHHCCCCC	9.35	25072903
250	Phosphorylation	DPLLHSYTKLKGQKK CHHHHCHHHCCCCCC	32.68	25072903
266 (in isoform 7)	Phosphorylation	-	7.80	30266825
267 (in isoform 7)	Phosphorylation	-	4.90	30266825
280	O-linked_Glycosylation	RAWIFEKSLVAFEGE EEEEEEEEEEEEECC	22.37	30379171
292	Ubiquitination	EGEGQFEKLCQESAK ECCCHHHHHHHHHHH	56.71	32015554
369	Phosphorylation	EAGIAAESLGEMAES HHCCCHHHHHHHHHH	36.63	27732954
376	Phosphorylation	SLGEMAESSGVSEEA HHHHHHHHCCCCHHH	23.89	20068231
377	Phosphorylation	LGEMAESSGVSEEAA HHHHHHHCCCCHHHH	34.42	22777824
380	Phosphorylation	MAESSGVSEEAAENP HHHHCCCCHHHHHCC	32.99	22777824
389	Phosphorylation	EAAENPKSVREECIP HHHHCCHHHHHHHHC	27.88	27251275
398	Acetylation	REECIPMKRRRRAKL HHHHHCHHHHHHHHH	37.08	25953088
404	Acetylation	MKRRRRAKLCSSAET HHHHHHHHHCCCCHH	48.49	23749302
407	Phosphorylation	RRRAKLCSSAETLES HHHHHHCCCCHHHHH	42.91	25159151
408	Phosphorylation	RRAKLCSSAETLESH HHHHHCCCCHHHHHC	29.18	25159151
411	Phosphorylation	KLCSSAETLESHPDI HHCCCCHHHHHCCCC	35.23	21712546
414	Phosphorylation	SSAETLESHPDIGKS CCCHHHHHCCCCCCC	43.35	22167270
420	Acetylation	ESHPDIGKSTPQKTA HHCCCCCCCCCCCCC	52.03	26051181
421	Phosphorylation	SHPDIGKSTPQKTAE HCCCCCCCCCCCCCC	39.86	23401153
422	Phosphorylation	HPDIGKSTPQKTAEA CCCCCCCCCCCCCCC	32.97	30266825
437	Phosphorylation	DPRRGVGSPPGRKKT CCCCCCCCCCCCCCC	26.05	30266825
442	Ubiquitination	VGSPPGRKKTTVSMP CCCCCCCCCCEECCC	61.46	24816145
443	Trimethylation	GSPPGRKKTTVSMPR CCCCCCCCCEECCCC	48.33	-
443	Acetylation	GSPPGRKKTTVSMPR CCCCCCCCCEECCCC	48.33	26051181
443	Methylation	GSPPGRKKTTVSMPR CCCCCCCCCEECCCC	48.33	23644510
444	Phosphorylation	SPPGRKKTTVSMPRS CCCCCCCCEECCCCC	35.15	20860994
445	Phosphorylation	PPGRKKTTVSMPRSR CCCCCCCEECCCCCC	21.33	20860994
447	Phosphorylation	GRKKTTVSMPRSRKG CCCCCEECCCCCCCC	22.45	20860994
479	Phosphorylation	VAEHPDASGEEIEEL HHHCCCCCHHHHHHH	54.86	-
481 (in isoform 6)	Phosphorylation	-	53.99	20068231
492	Phosphorylation	ELLRSQWSLLSEKQR HHHHHHHHHHCHHHH	16.28	26270265
495	Phosphorylation	RSQWSLLSEKQRARY HHHHHHHCHHHHHHH	48.30	21815630
497	Acetylation	QWSLLSEKQRARYNT HHHHHCHHHHHHHCC	41.53	26051181
518	Phosphorylation	PVQAEEDSGNVNGKK EEECCCCCCCCCCCC	35.23	21815630
524	Acetylation	DSGNVNGKKRNHTKR CCCCCCCCCCCCCCC	43.27	26051181
536	Phosphorylation	TKRIQDPTEDAEAED CCCCCCCCCCCCCCC	55.58	23403867
544	Phosphorylation	EDAEAEDTPRKRLRT CCCCCCCCCCHHHHC	19.25	29255136
551	Phosphorylation	TPRKRLRTDKHSLRK CCCHHHHCCHHHHCC	54.73	26434776
555	Phosphorylation	RLRTDKHSLRKRDTI HHHCCHHHHCCCCCC	35.29	26434776
565	Acetylation	KRDTITDKTARTSSY CCCCCCCHHHCHHHH	35.12	25953088
568	Ubiquitination	TITDKTARTSSYKAM CCCCHHHCHHHHHHH	40.13	24816145
571	Phosphorylation	DKTARTSSYKAMEAA CHHHCHHHHHHHHHH	30.00	29214152
573	Acetylation	TARTSSYKAMEAASS HHCHHHHHHHHHHHH	43.11	25953088
579	Phosphorylation	YKAMEAASSLKSQAA HHHHHHHHHHHHHHH	43.16	26714015
580	Phosphorylation	KAMEAASSLKSQAAT HHHHHHHHHHHHHHH	34.78	20068231
582	Methylation	MEAASSLKSQAATKN HHHHHHHHHHHHHCC	42.33	115978571
582	Ubiquitination	MEAASSLKSQAATKN HHHHHHHHHHHHHCC	42.33	32015554
583	Phosphorylation	EAASSLKSQAATKNL HHHHHHHHHHHHCCH	30.28	19413330
587	Phosphorylation	SLKSQAATKNLSDAC HHHHHHHHCCHHHHH	24.39	19413330
588	Acetylation	LKSQAATKNLSDACK HHHHHHHCCHHHHHH	51.68	25953088
588	Methylation	LKSQAATKNLSDACK HHHHHHHCCHHHHHH	51.68	115978579
588	Ubiquitination	LKSQAATKNLSDACK HHHHHHHCCHHHHHH	51.68	-
591	Phosphorylation	QAATKNLSDACKPLK HHHHCCHHHHHHHHH	32.33	-
595	Acetylation	KNLSDACKPLKKRNR CCHHHHHHHHHHCCH	55.92	25953088
604	Phosphorylation	LKKRNRASTAASSAL HHHCCHHHHHHHHHH	18.49	30266825
605	Phosphorylation	KKRNRASTAASSALG HHCCHHHHHHHHHHC	25.84	30266825
608	Phosphorylation	NRASTAASSALGFSK CHHHHHHHHHHCCCC	17.43	30266825
609	Phosphorylation	RASTAASSALGFSKS HHHHHHHHHHCCCCC	23.84	25850435
614	Phosphorylation	ASSALGFSKSSSPSA HHHHHCCCCCCCCCC	29.81	10470851
615	Methylation	SSALGFSKSSSPSAS HHHHCCCCCCCCCCC	52.69	115978587
616	Phosphorylation	SALGFSKSSSPSASL HHHCCCCCCCCCCCC	34.55	19690332
616 (in isoform 3)	Phosphorylation	-	34.55	30108239
616 (in isoform 5)	Phosphorylation	-	34.55	21955146
617	Phosphorylation	ALGFSKSSSPSASLT HHCCCCCCCCCCCCC	50.43	19690332
617 (in isoform 3)	Phosphorylation	-	50.43	30108239
617 (in isoform 5)	Phosphorylation	-	50.43	21955146
618	Phosphorylation	LGFSKSSSPSASLTE HCCCCCCCCCCCCCC	29.93	23663014
618 (in isoform 3)	Phosphorylation	-	29.93	30108239
618 (in isoform 5)	Phosphorylation	-	29.93	25159151
620	Phosphorylation	FSKSSSPSASLTENE CCCCCCCCCCCCCCC	32.22	28985074
620 (in isoform 3)	Phosphorylation	-	32.22	28387310
620 (in isoform 5)	Phosphorylation	-	32.22	30108239
622	Phosphorylation	KSSSPSASLTENEVS CCCCCCCCCCCCCCC	39.91	-
622 (in isoform 3)	Phosphorylation	-	39.91	30108239
622 (in isoform 5)	Phosphorylation	-	39.91	30108239
624 (in isoform 3)	Phosphorylation	-	33.98	27251275
624 (in isoform 5)	Phosphorylation	-	33.98	30108239
633 (in isoform 3)	Phosphorylation	-	56.73	27732954
658	O-linked_Glycosylation	VSVSSKKSERGVTAK EECCCCCCCCCCCCC	35.94	30379171
721	Acetylation	IHSCFVCKESKTDVK CEEEEEECCCCCCCC	60.77	26051181
737	Acetylation	CVVTQCGKFYHEACV EEEEECCHHHHHHHH	50.83	26051181
750	Phosphorylation	CVKKYPLTVFESRGF HHHHCCEEEEECCCC	20.74	28555341
754	Phosphorylation	YPLTVFESRGFRCPL CCEEEEECCCCCCCC	26.66	28555341
779	Acetylation	PSNPRPSKGKMMRCV CCCCCCCCCCCEEEE	66.29	19608861
781	Acetylation	NPRPSKGKMMRCVRC CCCCCCCCCEEEEEC	33.01	19608861
912	Sumoylation	PPNIQKMKHEIGEFP CCCHHHHHCCCCCCC	45.16	-
912	Sumoylation	PPNIQKMKHEIGEFP CCCHHHHHCCCCCCC	45.16	-
992	Ubiquitination	ERKPPPYKHIKVNKP HCCCCCCCCEECCCC	44.63	-
1006	Phosphorylation	PYGKVQIYTADISEI CCCEEEEEECCHHHC	4.45	27642862
1007	Phosphorylation	YGKVQIYTADISEIP CCEEEEEECCHHHCC	21.34	30576142
1011	Phosphorylation	QIYTADISEIPKCNC EEEECCHHHCCCCCC	29.98	30576142
1030	Phosphorylation	ENPCGFDSECLNRML CCCCCCCHHHHHHHH	28.13	30576142
1059	Acetylation	CQNQCFTKRQYPETK HCCCCCCCCCCCCCE	19.77	26051181
1059	Ubiquitination	CQNQCFTKRQYPETK HCCCCCCCCCCCCCE	19.77	-
1062	Phosphorylation	QCFTKRQYPETKIIK CCCCCCCCCCCEEEE	13.68	23403867
1065	Phosphorylation	TKRQYPETKIIKTDG CCCCCCCCEEEECCC	24.04	23403867
1066	Ubiquitination	KRQYPETKIIKTDGK CCCCCCCEEEECCCC	40.55	29967540
1069	Sumoylation	YPETKIIKTDGKGWG CCCCEEEECCCCCCE	44.00	-
1069	Sumoylation	YPETKIIKTDGKGWG CCCCEEEECCCCCCE	44.00	-
1070	Phosphorylation	PETKIIKTDGKGWGL CCCEEEECCCCCCEE	39.31	23403867
1080	Acetylation	KGWGLVAKRDIRKGE CCCEEEEECCCCCCC	43.02	25953088
1133	Ubiquitination	RIIDAGPKGNYSRFM CEECCCCCCCHHHHC	59.89	-
1207	Methylation	GFLGDRPKTSTTLSS CCCCCCCCCCCCCCH	56.87	98666279
1213	Phosphorylation	PKTSTTLSSEEKGKK CCCCCCCCHHHHCCC	33.34	24732914
1214	Phosphorylation	KTSTTLSSEEKGKKT CCCCCCCHHHHCCCC	53.54	21815630
1217	Methylation	TTLSSEEKGKKTKKK CCCCHHHHCCCCCHH	72.48	24129315
1231	Acetylation	KTRRRRAKGEGKRQS HHHHHHHCCCCCCCC	56.54	7479669
1238	Phosphorylation	KGEGKRQSEDECFRC CCCCCCCCCCCCEEC	51.56	25159151
1272	Acetylation	LSCLGLGKRPFGKWE HHHCCCCCCCCCCCC	63.04	23749302
1280	Ubiquitination	RPFGKWECPWHHCDV CCCCCCCCCCCCCCC	4.26	24816145
1316	Phosphorylation	DGTAFSCTPDGRSYC CCCCEEECCCCCCEE	24.18	25159151
1332	Phosphorylation	EHDLGAASVRSTKTE CCCCCCCCCCCCCCC	19.96	29396449
1335	Phosphorylation	LGAASVRSTKTEKPP CCCCCCCCCCCCCCC	31.90	21712546
1338	Phosphorylation	ASVRSTKTEKPPPEP CCCCCCCCCCCCCCC	49.70	22210691
1349	Ubiquitination	PPEPGKPKGKRRRRR CCCCCCCCCCCCCCC	79.24	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
102	S	Phosphorylation	Kinase	ATM	Q13315	PSP
172	S	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NSD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NSD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANDR_HUMAN	AR	physical	19481544
HDAC1_HUMAN	HDAC1	physical	16197452
SIN3B_HUMAN	SIN3B	physical	16197452
NSD2_HUMAN	WHSC1	physical	18156491
HDAC1_HUMAN	HDAC1	physical	18156491
HDAC2_HUMAN	HDAC2	physical	18156491
SIN3A_HUMAN	SIN3A	physical	18156491
HDAC1_HUMAN	HDAC1	physical	18172012
HDAC2_HUMAN	HDAC2	physical	18172012
H32_HUMAN	HIST2H3C	physical	21720545
IQGA1_HUMAN	IQGAP1	physical	22028615
TIAM1_HUMAN	TIAM1	physical	22028615
CTNB1_HUMAN	CTNNB1	physical	22028615
MDC1_HUMAN	MDC1	physical	21293379
A4_HUMAN	APP	physical	21832049
TIF1B_HUMAN	TRIM28	physical	22972034
HDAC1_HUMAN	HDAC1	physical	22972034
H31T_HUMAN	HIST3H3	physical	23269674
H31_HUMAN	HIST1H3A	physical	19481544
ESR1_HUMAN	ESR1	physical	24101509
NSD2_HUMAN	WHSC1	physical	24101509
GEMI4_HUMAN	GEMIN4	physical	24923560
GEMI5_HUMAN	GEMIN5	physical	24923560
DDX20_HUMAN	DDX20	physical	24923560
GOGA3_HUMAN	GOLGA3	physical	24923560
MBB1A_HUMAN	MYBBP1A	physical	24923560
PLEC_HUMAN	PLEC	physical	24923560
DAPLE_HUMAN	CCDC88C	physical	24923560
RL6_HUMAN	RPL6	physical	24923560
RBM10_HUMAN	RBM10	physical	24923560
KPRB_HUMAN	PRPSAP2	physical	24923560
TR150_HUMAN	THRAP3	physical	24923560
RLA0_HUMAN	RPLP0	physical	24923560
PTN13_HUMAN	PTPN13	physical	24923560
SMN_HUMAN	SMN1	physical	24923560
KIF11_HUMAN	KIF11	physical	24923560
MEP50_HUMAN	WDR77	physical	24923560
MYCB2_HUMAN	MYCBP2	physical	24923560
MAP1B_HUMAN	MAP1B	physical	24923560
SK2L2_HUMAN	SKIV2L2	physical	24923560
H31_HUMAN	HIST1H3A	physical	25494638
PCNA_HUMAN	PCNA	physical	26771714

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NSD2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-779 AND LYS-781, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110; THR-114; SER-121;SER-376 AND THR-544, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110; THR-114; THR-115;SER-121 AND THR-544, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110; THR-115; SER-121AND THR-544, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437 AND THR-544, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-544, AND MASSSPECTROMETRY.	17081983 [Abstract]