dbPTM

DAPLE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DAPLE_HUMAN
UniProt AC	Q9P219
Protein Name	Protein Daple
Gene Name	CCDC88C
Organism	Homo sapiens (Human).
Sequence Length	2028
Subcellular Localization	Cytoplasm .
Protein Description	Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway. [PubMed: 25062847]
Protein Sequence	MDVTVSELLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHVNNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKRGSPHRGSLDRTDASTDLAMRSWPSELGSRTCSTSATTTAPSNSTPIARHPGRTKGYNSDDNLCEPSLEFEVPNHRQYVSRPSSLESSRNTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPSRDLATLPREASTPGRNALGRHEYPLPRNGPLPQEGAQKRGTAPPYVGVRPCSASPSSEMVTLEEFLEESNRSSPTHDTPSCRDDLLSDYFRKASDPPAIGGQPGPPAKKEGAKMPTNFVAPTVKMAAPTSEGRPLKPGQYVKPNFRLTEAEAPPSVAPRQAQPPQSLSLGRPRQAPVPPASHAPASRSASLSRAFSLASADLLRASGPEACKQESPQKLGAPEALGGRETGSHTLQSPAPPSSHSLARERTPLVGKAGSSCQGPGPRSRPLDTRRFSLAPPKEERLAPLHQSATAPAIATAGAGAAAAGSGSNSQLLHFSPAAAPAARTKPKAPPRSGEVATITPVRAGLSLSEGDGVPGQGCSEGLPAKSPGRSPDLAPHLGRALEDCSRGSVSKSSPASPEPGGDPQTVWYEYGCV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Ubiquitination	PTNQRINKHVNNDVN CCCHHHHHHCCCCCC	46.70	-
87	Phosphorylation	ILVRNIKTYYQEVLQ HHHHHHHHHHHHHHH	24.54	-
113	Phosphorylation	MIGRDPLSGKSMEEI EEECCCCCCCCHHHH	49.95	25003641
115 (in isoform 2)	Phosphorylation	-	43.16	21406692
116	Phosphorylation	RDPLSGKSMEEIKKV CCCCCCCCHHHHHHH	34.65	25003641
116 (in isoform 2)	Phosphorylation	-	34.65	21406692
219	Phosphorylation	DLTQERDYLQAQHPP HHHHHHHHHHHCCCC	13.61	23403867
227	Phosphorylation	LQAQHPPSPIKSSSA HHHCCCCCCCCCCCC	43.65	25159151
231	Phosphorylation	HPPSPIKSSSADSTP CCCCCCCCCCCCCCC	30.19	26074081
232	Phosphorylation	PPSPIKSSSADSTPS CCCCCCCCCCCCCCC	25.25	26074081
233	Phosphorylation	PSPIKSSSADSTPSP CCCCCCCCCCCCCCC	43.09	26074081
236	Phosphorylation	IKSSSADSTPSPTSS CCCCCCCCCCCCCCC	41.77	26074081
237	Phosphorylation	KSSSADSTPSPTSSL CCCCCCCCCCCCCCC	28.47	26074081
239	Phosphorylation	SSADSTPSPTSSLSS CCCCCCCCCCCCCCH	40.68	25159151
241	Phosphorylation	ADSTPSPTSSLSSED CCCCCCCCCCCCHHH	34.97	28985074
242	Phosphorylation	DSTPSPTSSLSSEDK CCCCCCCCCCCHHHH	32.44	26074081
243	Phosphorylation	STPSPTSSLSSEDKQ CCCCCCCCCCHHHHH	34.45	26074081
245	Phosphorylation	PSPTSSLSSEDKQHL CCCCCCCCHHHHHHH	33.36	28985074
246	Phosphorylation	SPTSSLSSEDKQHLA CCCCCCCHHHHHHHH	55.92	26074081
333	Phosphorylation	ERLELELTRCKEKLH HHHHHHHHHHHHHHC	25.33	25954137
365	Sulfoxidation	ILIETKAMLEEQLTA EEECHHHHHHHHHHH	5.29	21406390
446	Phosphorylation	LSKNADLSDASRKSF HHCCCCCCHHHHHHH	31.51	21815630
449	Phosphorylation	NADLSDASRKSFVFE CCCCCHHHHHHHHHH	45.27	24719451
452	Phosphorylation	LSDASRKSFVFELNE CCHHHHHHHHHHHHH	26.07	27251275
470	Ubiquitination	SRILKLEKENQSLQS HHHHHHHHHCHHHHH	72.84	-
474	Phosphorylation	KLEKENQSLQSTIQG HHHHHCHHHHHHHHH	39.70	28555341
486	Phosphorylation	IQGLRDASLVLEESG HHHHHHHHHHHHHHC	24.25	25159151
495	Ubiquitination	VLEESGLKCGELEKE HHHHHCCCHHHHHHH	43.66	-
521	Ubiquitination	QTQLEREKQSNQDLE HHHHHHHHHCCHHHH	66.31	-
523	Phosphorylation	QLEREKQSNQDLETL HHHHHHHCCHHHHHH	47.75	26270265
529	Phosphorylation	QSNQDLETLSEELIR HCCHHHHHHHHHHHH	42.77	26270265
531	Phosphorylation	NQDLETLSEELIREK CHHHHHHHHHHHHHH	36.12	26270265
563	Ubiquitination	IKDLEQEKDHLNRAM HHHHHHHHHHHHHHH	50.58	-
572	Phosphorylation	HLNRAMWSLRERSQV HHHHHHHHHHHHHHH	12.40	23403867
580	Phosphorylation	LRERSQVSSEARMKD HHHHHHHCHHHHHHH	18.15	-
581	Phosphorylation	RERSQVSSEARMKDV HHHHHHCHHHHHHHH	36.10	-
598	Phosphorylation	ENKALHQTVTEANGK HHHHHHHHHHHHHCH	20.74	27134283
600	Phosphorylation	KALHQTVTEANGKLS HHHHHHHHHHHCHHH	32.54	27134283
613	Ubiquitination	LSQLEFEKRQLHRDL HHHHHHHHHHHHHHH	51.25	-
681	Phosphorylation	ENRTLRKSLDTLQNV CHHHHHHHHHHHHHH	25.66	22496350
684	Phosphorylation	TLRKSLDTLQNVSLQ HHHHHHHHHHHHHHH	35.22	20068231
689	Phosphorylation	LDTLQNVSLQLEGLE HHHHHHHHHHHHHHH	20.25	20068231
700	Ubiquitination	EGLERDNKQLDAENL HHHHHCCCCCCHHHH	57.43	-
765	Phosphorylation	ELSYQSVSAENLRLQ CEEEECCCHHHHHHH	34.80	28348404
869	Phosphorylation	LSAVEKESRALDKEL HHHHHHHHHHHHHHH	33.64	23898821
891	Acetylation	GKLKELEKDNRDLTK HHHHHHHHHCCCCHH	73.29	20167786
898	Acetylation	KDNRDLTKQVTVHAR HHCCCCHHHHHHHHH	50.50	20167786
951	Phosphorylation	LLLQEDDSGSDTKYK HHCCCCCCCCCCCEE	53.14	27251275
953	Phosphorylation	LQEDDSGSDTKYKIL CCCCCCCCCCCEEEE	46.16	21815630
998	Phosphorylation	SLNRQLESELQMLKK HHHHHHHHHHHHHHH	57.13	24702127
1023	Phosphorylation	EGQHLQNSFKHPAGK CCHHHHHHCCCCCCC	23.78	23401153
1049	Phosphorylation	GPGHKEATMELLRVK CCCCHHHHHHHHHHH	16.57	28509920
1050	Sulfoxidation	PGHKEATMELLRVKD CCCHHHHHHHHHHHH	4.38	21406390
1073	Ubiquitination	NAALQAEKQLLKEQL HHHHHHHHHHHHHHH	49.62	-
1193	Phosphorylation	EALIRQHSCLKTLHR HHHHHHHHHHHHHHH	16.89	-
1196	Ubiquitination	IRQHSCLKTLHRNLE HHHHHHHHHHHHHHH	54.06	-
1231	Phosphorylation	EEREKVLTTEREALQ HHHHHHHHHHHHHHH	29.60	-
1248	Sulfoxidation	QRTNALAMGENQRLR HHHCHHHHHCHHHHH	7.81	21406390
1272	Phosphorylation	HHQLKGEYEELHAHT HHHHHHCHHHHHHHH	24.30	28102081
1313	Phosphorylation	QHQTMDISLTKLDNH HHHHCCCEEHHHHHH	26.23	24719451
1325	Phosphorylation	DNHCELLSRLKGNLE HHHHHHHHHHCCCCH	48.46	24719451
1387	Ubiquitination	HKEKLEEKIMDQYKF HHHHHHHHHHHHHCC	33.67	-
1395	Phosphorylation	IMDQYKFYDPPPKKK HHHHHCCCCCCCCCC	24.32	28796482
1409	Ubiquitination	KNHWIGAKALVKLIK CCCCCCHHHHHHHHC	36.72	-
1428	Phosphorylation	GSRERLKSTVDSPPW CCHHHHHHCCCCCCC	37.95	23401153
1429	Phosphorylation	SRERLKSTVDSPPWQ CHHHHHHCCCCCCCC	27.09	30576142
1432	Phosphorylation	RLKSTVDSPPWQLES HHHHCCCCCCCCCCC	28.64	25159151
1439	Phosphorylation	SPPWQLESSDPASPA CCCCCCCCCCCCCCC	48.94	25159151
1440	Phosphorylation	PPWQLESSDPASPAA CCCCCCCCCCCCCCC	37.93	25159151
1444	Phosphorylation	LESSDPASPAASQPL CCCCCCCCCCCCCCH	22.06	25159151
1448	Phosphorylation	DPASPAASQPLRSQA CCCCCCCCCCHHHHC	34.14	27732954
1460	Phosphorylation	SQAENPDTPALGSNC HHCCCCCCCCCCCCC	16.24	21815630
1477	Phosphorylation	ERDAHNGSVGKGPGD CHHCCCCCCCCCCCC	32.77	28348404
1491	Phosphorylation	DLKPKRGSPHRGSLD CCCCCCCCCCCCCCC	22.90	20873877
1496	O-linked_Glycosylation	RGSPHRGSLDRTDAS CCCCCCCCCCCCCCC	27.36	30379171
1496	Phosphorylation	RGSPHRGSLDRTDAS CCCCCCCCCCCCCCC	27.36	20873877
1500	Phosphorylation	HRGSLDRTDASTDLA CCCCCCCCCCCHHHH	35.27	29449344
1503	Phosphorylation	SLDRTDASTDLAMRS CCCCCCCCHHHHHHC	25.84	30243723
1504	Phosphorylation	LDRTDASTDLAMRSW CCCCCCCHHHHHHCC	36.43	30243723
1510	Phosphorylation	STDLAMRSWPSELGS CHHHHHHCCCHHHCC	30.19	24719451
1513	Phosphorylation	LAMRSWPSELGSRTC HHHHCCCHHHCCCCC	38.91	23312004
1521	Phosphorylation	ELGSRTCSTSATTTA HHCCCCCCCCCCCCC	25.45	29396449
1522	Phosphorylation	LGSRTCSTSATTTAP HCCCCCCCCCCCCCC	25.24	25627689
1525	Phosphorylation	RTCSTSATTTAPSNS CCCCCCCCCCCCCCC	25.17	25627689
1526	Phosphorylation	TCSTSATTTAPSNST CCCCCCCCCCCCCCC	22.22	27251275
1527	Phosphorylation	CSTSATTTAPSNSTP CCCCCCCCCCCCCCC	32.01	25159151
1530	Phosphorylation	SATTTAPSNSTPIAR CCCCCCCCCCCCCCC	40.73	28985074
1532	Phosphorylation	TTTAPSNSTPIARHP CCCCCCCCCCCCCCC	39.64	25159151
1533	Phosphorylation	TTAPSNSTPIARHPG CCCCCCCCCCCCCCC	23.98	21815630
1542	Phosphorylation	IARHPGRTKGYNSDD CCCCCCCCCCCCCCC	34.43	-
1545	Phosphorylation	HPGRTKGYNSDDNLC CCCCCCCCCCCCCCC	17.04	28450419
1547	Phosphorylation	GRTKGYNSDDNLCEP CCCCCCCCCCCCCCC	37.55	25159151
1555	Phosphorylation	DDNLCEPSLEFEVPN CCCCCCCCCEEECCC	20.45	23927012
1566	Phosphorylation	EVPNHRQYVSRPSSL ECCCCHHHCCCCHHH	10.59	23312004
1568	Phosphorylation	PNHRQYVSRPSSLES CCCHHHCCCCHHHCC	33.27	27251275
1571	Phosphorylation	RQYVSRPSSLESSRN HHHCCCCHHHCCCCC	46.58	25159151
1572	Phosphorylation	QYVSRPSSLESSRNT HHCCCCHHHCCCCCC	38.55	25159151
1575	Phosphorylation	SRPSSLESSRNTSSN CCCHHHCCCCCCCCC	39.63	27251275
1576	Phosphorylation	RPSSLESSRNTSSNS CCHHHCCCCCCCCCC	21.85	27251275
1579	Phosphorylation	SLESSRNTSSNSSPL HHCCCCCCCCCCCCC	32.21	23403867
1580	Phosphorylation	LESSRNTSSNSSPLN HCCCCCCCCCCCCCC	30.95	23403867
1581	Phosphorylation	ESSRNTSSNSSPLNL CCCCCCCCCCCCCCC	38.40	23403867
1583	Phosphorylation	SRNTSSNSSPLNLKG CCCCCCCCCCCCCCC	34.97	23403867
1584	Phosphorylation	RNTSSNSSPLNLKGS CCCCCCCCCCCCCCC	37.34	25159151
1591	Phosphorylation	SPLNLKGSSEQLHGR CCCCCCCCHHHHCCC	29.16	23927012
1592	Phosphorylation	PLNLKGSSEQLHGRS CCCCCCCHHHHCCCC	37.72	25849741
1599	Phosphorylation	SEQLHGRSESFSSED HHHHCCCCCCCCHHH	42.03	23403867
1601	Phosphorylation	QLHGRSESFSSEDLI HHCCCCCCCCHHHCC	31.51	28355574
1603	Phosphorylation	HGRSESFSSEDLIPS CCCCCCCCHHHCCCC	41.94	22617229
1604	Phosphorylation	GRSESFSSEDLIPSR CCCCCCCHHHCCCCC	32.87	22617229
1610	Phosphorylation	SSEDLIPSRDLATLP CHHHCCCCCCCCCCC	31.28	23403867
1615	Phosphorylation	IPSRDLATLPREAST CCCCCCCCCCCCCCC	44.59	24719451
1651	Phosphorylation	EGAQKRGTAPPYVGV CHHHHCCCCCCCCCC	39.77	28102081
1662	Phosphorylation	YVGVRPCSASPSSEM CCCCCCCCCCCCCCC	34.17	26657352
1664	Phosphorylation	GVRPCSASPSSEMVT CCCCCCCCCCCCCCC	14.71	28102081
1666	Phosphorylation	RPCSASPSSEMVTLE CCCCCCCCCCCCCHH	36.11	28348404
1667	Phosphorylation	PCSASPSSEMVTLEE CCCCCCCCCCCCHHH	32.85	28348404
1671	Phosphorylation	SPSSEMVTLEEFLEE CCCCCCCCHHHHHHH	27.43	22210691
1679	Phosphorylation	LEEFLEESNRSSPTH HHHHHHHHCCCCCCC	28.32	28348404
1682	Phosphorylation	FLEESNRSSPTHDTP HHHHHCCCCCCCCCC	44.94	27732954
1683	Phosphorylation	LEESNRSSPTHDTPS HHHHCCCCCCCCCCC	30.49	27732954
1685	Phosphorylation	ESNRSSPTHDTPSCR HHCCCCCCCCCCCHH	34.04	27732954
1688	Phosphorylation	RSSPTHDTPSCRDDL CCCCCCCCCCHHHHH	14.97	28348404
1690	Phosphorylation	SPTHDTPSCRDDLLS CCCCCCCCHHHHHHH	24.71	28348404
1699	Phosphorylation	RDDLLSDYFRKASDP HHHHHHHHHHHHCCC	11.25	27259358
1704	Phosphorylation	SDYFRKASDPPAIGG HHHHHHHCCCCCCCC	54.40	23312004
1732	Phosphorylation	PTNFVAPTVKMAAPT CCCCCCCCCEECCCC	24.03	25332170
1740	Phosphorylation	VKMAAPTSEGRPLKP CEECCCCCCCCCCCC	36.67	25159151
1776	Phosphorylation	RQAQPPQSLSLGRPR CCCCCCCCCCCCCCC	26.21	23312004
1778	Phosphorylation	AQPPQSLSLGRPRQA CCCCCCCCCCCCCCC	33.74	28348404
1791	O-linked_Glycosylation	QAPVPPASHAPASRS CCCCCCCCCCCCCCC	26.42	30379171
1796	Phosphorylation	PASHAPASRSASLSR CCCCCCCCCCHHHHH	26.21	29759185
1800	Phosphorylation	APASRSASLSRAFSL CCCCCCHHHHHHHHH	28.29	27174698
1802	Phosphorylation	ASRSASLSRAFSLAS CCCCHHHHHHHHHHH	21.04	27174698
1806	Phosphorylation	ASLSRAFSLASADLL HHHHHHHHHHHHHHH	23.26	23401153
1809	Phosphorylation	SRAFSLASADLLRAS HHHHHHHHHHHHHHH	27.84	23403867
1816	Phosphorylation	SADLLRASGPEACKQ HHHHHHHHCHHHHHC	48.74	23312004
1825	Phosphorylation	PEACKQESPQKLGAP HHHHHCCCCCCCCCC	30.09	29214152
1840	Phosphorylation	EALGGRETGSHTLQS CHHCCCCCCCCCCCC	42.49	27251275
1842	Phosphorylation	LGGRETGSHTLQSPA HCCCCCCCCCCCCCC	22.25	25159151
1844	Phosphorylation	GRETGSHTLQSPAPP CCCCCCCCCCCCCCC	28.34	26657352
1847	Phosphorylation	TGSHTLQSPAPPSSH CCCCCCCCCCCCCCC	26.58	25159151
1852	Phosphorylation	LQSPAPPSSHSLARE CCCCCCCCCCCCCCC	39.36	27251275
1853	Phosphorylation	QSPAPPSSHSLARER CCCCCCCCCCCCCCC	23.91	27251275
1855	Phosphorylation	PAPPSSHSLARERTP CCCCCCCCCCCCCCC	26.18	27251275
1861	Phosphorylation	HSLARERTPLVGKAG CCCCCCCCCCCCCCC	19.07	24719451
1887	Phosphorylation	PLDTRRFSLAPPKEE CCCCCCCCCCCCCHH	23.08	23403867
1902	Phosphorylation	RLAPLHQSATAPAIA HCCCCCCCCCCCHHH	19.48	28348404
1904	Phosphorylation	APLHQSATAPAIATA CCCCCCCCCCHHHCC	38.12	28348404
1920	Phosphorylation	AGAAAAGSGSNSQLL CCHHHCCCCCCCCEE	34.03	28348404
1922	Phosphorylation	AAAAGSGSNSQLLHF HHHCCCCCCCCEEEC	34.70	28348404
1924	Phosphorylation	AAGSGSNSQLLHFSP HCCCCCCCCEEECCC	24.73	28348404
1930	Phosphorylation	NSQLLHFSPAAAPAA CCCEEECCCCCCCCC	11.68	25159151
1947	Phosphorylation	KPKAPPRSGEVATIT CCCCCCCCCCCCEEC	45.11	27251275
1952	Phosphorylation	PRSGEVATITPVRAG CCCCCCCEECCEECC	30.47	27251275
1954	Phosphorylation	SGEVATITPVRAGLS CCCCCEECCEECCCC	16.04	21815630
1961	Phosphorylation	TPVRAGLSLSEGDGV CCEECCCCCCCCCCC	29.00	28348404
1963	Phosphorylation	VRAGLSLSEGDGVPG EECCCCCCCCCCCCC	35.84	28348404
1974	Phosphorylation	GVPGQGCSEGLPAKS CCCCCCCCCCCCCCC	41.33	23312004
1981	Phosphorylation	SEGLPAKSPGRSPDL CCCCCCCCCCCCCCC	34.39	20363803
1985	Phosphorylation	PAKSPGRSPDLAPHL CCCCCCCCCCCHHHH	28.78	20363803
2000	Phosphorylation	GRALEDCSRGSVSKS HHHHHHHCCCCCCCC	52.58	25159151
2003	Phosphorylation	LEDCSRGSVSKSSPA HHHHCCCCCCCCCCC	23.31	25159151
2011	Phosphorylation	VSKSSPASPEPGGDP CCCCCCCCCCCCCCC	32.93	24719451
2023	Phosphorylation	GDPQTVWYEYGCV-- CCCCCEEEEECCC--	8.57	-
2025	Phosphorylation	PQTVWYEYGCV---- CCCEEEEECCC----	10.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2023	Y	Phosphorylation	Kinase	SRC	P12931	PSP
2025	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
2025	Y	Phosphorylation	Kinase	INSR	P06213	PSP
2025	Y	Phosphorylation	Kinase	PDGFRA	P16234	PSP
2025	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DAPLE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DAPLE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
WDFY1_HUMAN	WDFY1	physical	28514442
RNAS7_HUMAN	RNASE7	physical	28514442
AL1L1_HUMAN	ALDH1L1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
236600	Hydrocephalus, non-syndromic, autosomal recessive 1 (HYC1)
616053	Spinocerebellar ataxia 40 (SCA40)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DAPLE_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1444, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1806, AND MASSSPECTROMETRY.	18669648 [Abstract]