ZCHC9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZCHC9_HUMAN
• UniProt AC: Q8N567
• Protein Name: Zinc finger CCHC domain-containing protein 9
• Gene Name: ZCCHC9
• Organism: Homo sapiens (Human).
• Sequence Length: 271
• Subcellular Localization: Nucleus, nucleolus . Nucleus . Expressed throughout the nucleus and concentrated mainly in the nucleolus.
• Protein Description: May down-regulate transcription mediated by NF-kappa-B and the serum response element..
• Protein Sequence: MTRWARVSTTYNKRPLPATSWEDMKKGSFEGTSQNLPKRKQLEANRLSLKNDAPQAKHKKNKKKKEYLNEDVNGFMEYLRQNSQMVHNGQIIATDSEEVREEIAVALKKDSRREGRRLKRQAAKKNAMVCFHCRKPGHGIADCPAALENQDMGTGICYRCGSTEHEITKCKAKVDPALGEFPFAKCFVCGEMGHLSRSCPDNPKGLYADGGGCKLCGSVEHLKKDCPESQNSERMVTVGRWAKGMSADYEEILDVPKPQKPKTKIPKVVNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MTRWARVSTTYNKRP CCCEEEEECCCCCCC	14.96	25003641
9	Phosphorylation	TRWARVSTTYNKRPL CCEEEEECCCCCCCC	30.37	29507054
10	Phosphorylation	RWARVSTTYNKRPLP CEEEEECCCCCCCCC	20.00	25003641
11	Phosphorylation	WARVSTTYNKRPLPA EEEEECCCCCCCCCC	20.83	25003641
19	Phosphorylation	NKRPLPATSWEDMKK CCCCCCCCCHHHHHC	32.22	27251275
20	Phosphorylation	KRPLPATSWEDMKKG CCCCCCCCHHHHHCC	30.49	27251275
25	Acetylation	ATSWEDMKKGSFEGT CCCHHHHHCCCCCCC	67.32	25953088
26	Acetylation	TSWEDMKKGSFEGTS CCHHHHHCCCCCCCC	53.82	11924425
28	Phosphorylation	WEDMKKGSFEGTSQN HHHHHCCCCCCCCCC	29.07	25159151
48	Phosphorylation	QLEANRLSLKNDAPQ HHHHHHHHHCCCCHH	33.78	25159151
50	Acetylation	EANRLSLKNDAPQAK HHHHHHHCCCCHHHH	49.78	25953088
83	Phosphorylation	MEYLRQNSQMVHNGQ HHHHHHHCCCEECCE	16.00	-
173	Sumoylation	EITKCKAKVDPALGE HHHHCCCCCCHHHCC	32.44	-
173	Sumoylation	EITKCKAKVDPALGE HHHHCCCCCCHHHCC	32.44	-
207	Phosphorylation	PDNPKGLYADGGGCK CCCCCCCEECCCCCC	16.00	27642862
218	Phosphorylation	GGCKLCGSVEHLKKD CCCCCCCCHHHHHHH	24.28	25159151
243	Acetylation	VTVGRWAKGMSADYE EEHHHHHHCCCCCHH	48.46	19413330
246	Phosphorylation	GRWAKGMSADYEEIL HHHHHCCCCCHHHHH	27.02	29978859
249	Phosphorylation	AKGMSADYEEILDVP HHCCCCCHHHHHCCC	18.38	28796482
263	Phosphorylation	PKPQKPKTKIPKVVN CCCCCCCCCCCCCCC	42.61	20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZCHC9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZCHC9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZCHC9_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZCHC9_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.